Absolutely insane numbers from Eli Lilly this morning. 15 billion dollars in sales for tirzepatide alone, in just 90 days. Now on track to ~55-60 billion in sales for one drug. We need a different term than blockbuster drug. This is wild.
David W (aka Flex NP)
@rnflex.bsky.social
Jack of all trades nurse practitioner, trail runner photographer, coonhound rescuer, lover of glucagon agonism in the liver, kidney and pancreas, fascinated by obesity medicine, retatrutide fan boy, thoughts my own not my employers
How do you hide poor trial results? In your earnings report with 8pt font. Reimagine 4, Cagrisema vs Tirzepatide again shows the superiority of Tirzepatide. Statistically significant better A1c reduction and numerically better weight loss from the efficacy estimand. What's that mean in English?
www.otsuka-us.com/news/otsuka-... #NephSky #IgANephropathy #IgAN
Otsuka Unveils Unprecedented Phase 3 VISIONARY Two-Year eGFR Results Demonstrating VOYXACT® (sibeprenlimab-szsi) Stabilizes Kidney Function Decline to Baseline Physiologic Rate, Fundamentally Altering...
Otsuka Pharmaceutical Development & Commercialization, Inc. and Otsuka Pharmaceutical Co., Ltd. announced new data from the Phase 3 VISIONARY trial demonstrating that VOYXACT® (sibeprenlimab-szsi) sta...
otsuka-us.com
Some insurance companies are really out of control. Patient denied a medication today because I didn't provide proof they had abstained from alcohol. In fact the patient has had 3 negative PEth tests(which detects chronic alcohol use) they don't drink alcohol! I just can't even anymore 🤬🤬🤬
Sunday chicken wing dinner Dry rub with the 3 besties. Convection roast 400F for ~20 minutes, wings out, turn for even cooking back into 440F oven. After 10 minutes turn wings again, back in for another 10-15 minutes until golden. Sauce: Teriyaki 1/4 cup + Chiltepin sauce 1 tbsp, mix Devour.
Already seeing my patients benefiting from the Medicare bridge program for GLP1 access. First followup patient today. Reduced inhaler use, less joint pain, steady weight loss and minimal side effects. All hail Zepbound!
My cousin who is a patient in the Triumph 6 trial for retatrutide. 60 weeks in, down 125lbs, about 39% of his body weight. From 321lbs --> 196lbs 12mg dose, minimal side effects. Still has a other 1+ year in the trial to go and still losing weight. Current BMI now 25.2, starting was 41.2 🔥
I dunno but it should probably be a bigger deal that the White House announced it wants to slap a 100% tariff on drug imports at the same time it is eliminating Medicare drug subsidies. And we’re talking about critical life-saving drugs like insulin, blood thinners, antibiotics, and heart meds.
More retatrutide results! Triumph 2 & 3. One for diabetes and one for patients with existing cardiovascular disease. The weight loss again was incredible, over 20% for diabetics! A first! But the cardiovascular data was underpowered 👎 And Lilly anticipates sending in for FDA approval in Q1 2027!
Retatrutide revolution continues
Weight loss remains the star of the show, but cardiovascular data was underpowered
the-incretins.beehiiv.com
More retatrutide results! Triumph 2 & 3. One for diabetes and one for patients with existing cardiovascular disease. The weight loss again was incredible, over 20% for diabetics! A first! But the cardiovascular data was underpowered 👎 And Lilly anticipates sending in for FDA approval in Q1 2027!
Retatrutide revolution continues
Weight loss remains the star of the show, but cardiovascular data was underpowered
the-incretins.beehiiv.com
Saw 17 patients in clinic today, wrote up 2,000 words on the recent retatrutide Triumph 2 and 3 trial topline readout, to be published tomorrow on the Incretin Space and cleared out my Epic inbox after being off work for 6 days. Time for a cold beverage, Japanese curry and a comfy chair.
Driving to the clinic and a literal skunk was walking down the side of the road just now. Good omen? Bad omen? Just weird on a Monday? All of the above?
LAX going from domestic to international terminal or vice versa is an Odyssey every single time.
Vitamin Bee 🐝@vitaminpac1.bsky.social · last wk.Like this if you’ve had your own personal Oddyssey (went to LaGuardia instead of JFK)
There's a naan-zero chance a purpose baked naan bread thrown like a frisbee is gonna go way further. Plus a baguette isn't dense enough to go far despite its torpedo shape.
post malone ergo propter malone@proptermalone.bsky.social · 2w agomy intuition is that an arbitrarily chosen baguette has the advantage but that naan benefits more from engineering and a purpose-built throwing naan is probably ahead of a purpose-built throwing baguette
Full details here, Triumph 2- obese diabetics, Triumph 3 50% diabetic/50% non diabetic all with previous cardiovascular disease. Both these trials were a mix of WOW great and Hmmm that's odd 🤔
Lilly's triple agonist, retatrutide, successful in two additional Phase 3 obesity trials, delivering significant improvements in weight and A1C | Eli Lilly and Company
The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.
investor.lilly.com
David W (aka Flex NP)@rnflex.bsky.social · 2w agoOf course I'm on vacation when Lilly announces new retatrutide results so I can't update my blog because I'm not typing out a detailed article on my phone 🤣
Have lived in homes with all 3 kinds of stovetops. I currently have induction and it's honestly amazing. I couldn't go back to either electric and certainly not gas now that I've got small children. Induction all the way.
George Pearkes@peark.es · 2w agoMan am I glad we’re getting an induction stove. www.jaci-inpractice.org/article/S221...
Full details here, Triumph 2- obese diabetics, Triumph 3 50% diabetic/50% non diabetic all with previous cardiovascular disease. Both these trials were a mix of WOW great and Hmmm that's odd 🤔
Lilly's triple agonist, retatrutide, successful in two additional Phase 3 obesity trials, delivering significant improvements in weight and A1C | Eli Lilly and Company
The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.
investor.lilly.com
David W (aka Flex NP)@rnflex.bsky.social · 2w agoOf course I'm on vacation when Lilly announces new retatrutide results so I can't update my blog because I'm not typing out a detailed article on my phone 🤣
Of course I'm on vacation when Lilly announces new retatrutide results so I can't update my blog because I'm not typing out a detailed article on my phone 🤣
#NephJC #TenPostNephJC FIND-CKD asks: Can we extend nsMRA cardiorenal benefits to the massive population with CKD without diabetes? Let’s FIND out! 🔍 Read the article 👇: pubmed.ncbi.nlm.nih.gov/42246672/ 1/10🧵
In what might be a really really bad idea, Novo Nordisk is suing Eli Lilly claiming misleading advertising over how much weight loss Tirzepatide causes versus Semaglutide. Lilly used the data from Surmount 5 which was a head to head trial of the two drugs in recent advertising.
Novo Nordisk Says It’s Suing Eli Lilly Over Weight-Loss Ads
Novo Nordisk A/S sued Eli Lilly & Co., accusing its rival of misleading advertising as competition in the US market for obesity drugs ratchets up further.
bloomberg.com
It's getting really ugly with GLP1 RA especially because they're usually comparing data from older drugs that are rarely prescribed anymore. Just worthless.
Mike Johansen@mikejohansenmd.medsky.social · 2w agoAs the author of 1 meta-analysis with @christosargyrop.bsky.social; I will state that I have a large amount of dislike for meta-analysis. It is a tool that has a purpose, but has become a hammer looking at everything as a nail.
👀 Seek and you shall FIND 🔎 #ERA26 #NephSky FIND-CKD asks if finerenone is beneficial in patients with non-diabetic CKD. Blog by @manoleaandreea.bsky.social & @divyaveerssneph.bsky.social www.nephjc.com/news/2026/7/6/find-ckd
Beyond Diabetic Kidney Disease: FIND-ing Finerenone's Next Role — NephJC
FIND-CKD extends finerenone beyond diabetic kidney disease, showing slower eGFR decline and sustained albuminuria reduction in non-diabetic CKD. While the benefits are modest and cardiovascular effect...
nephjc.com
Want more?? #NephSky #NephJC 🩳FIND-CKD shorts from @CristinaDeReins Finerenone in glomerulonephritis & a pooled analysis of safety and efficacy in CKD (INFINITY) www.nephjc.com/news/2026/7/20/finerenone-shorts
Finerenone across the proteinuric CKD spectrum — NephJC
Cristina Popa dissects the FIND-CKD extras: GN subgroup and INFINITY analysis
nephjc.com
One of the most difficult parts of primary care is having to give good, kind people terrible news about their health.
I've now ruined pineapple for myself. Sorta like backyard garden tomatoes are infinitely better than store bought? Same thing here. Low acid, super sweet and juicy. Like the best pineapple I've had outside of when I was in Tahiti/French Polynesia 8 years ago.
David W (aka Flex NP)@rnflex.bsky.social · 2w agoAbout 26 months ago I planted the crown of a pineapple in a pot and kept it growing over 2 winters and this morning I harvested it!
About 26 months ago I planted the crown of a pineapple in a pot and kept it growing over 2 winters and this morning I harvested it!
🔍FIND-CKD🔎 💊Use of finerenone in non-diabetic CKD #NephJC #NephSky #ERA26 VA by @drbarbateba.bsky.social www.nephjc.com/news/2026/7/17/find-ckd-the-visual-abstract
FIND CKD: The Visual Abstract — NephJC
Is finerenone ready to move beyond diabetes? The FIND-CKD phase 3 arrived from the #ERA26 and is the first one to show kidney protection with finerenone in non-diabetic CKD. The next challenge is no...
nephjc.com
Every single cyclosporiasis test except one I've ordered has come back positive so far. So that's cool. Cool cool cool. The one that was negative for cylospora was positive for shigellosis. So that's extra fun.