We worked hard to revise our #psilocybin & #ketamine snRNA-seq study to make it a resource. Interactive web portal: psilo-seq.kwanlab.org Annotated to @alleninstitute.org’s 16 neuronal and non-neuronal cell types, with updated analyses in preprint: www.biorxiv.org/content/10.1... Check it out!

Serotonin biology as a basis for explaining psychedelic drug action - I learned a lot writing this review with @neuroknox.bsky.social www.cell.com/current-biol... We know a good deal about serotonin, which should teach us how psychedelics work. But what’s the same? What’s different? 🤔

Serotonin biology as a basis for explaining psychedelic drug action

Knox et al. compare and contrast the biological effects of endogenous serotonin with psychedelics.

cell.com

Too many neuro preprints to keep track of, so I made a monthly ranking of the most-read ones on bioRxiv. Not a measure of quality, just what people are reading. Here's the fresh ranking for September: robertodf.github.io/biorxiv-top/

Feeling really proud of this one: a review of Bayesian efficient coding with Máté Lengyel and Paul Bays (@bayslab.org) is now available online in TICS! authors.elsevier.com/a/1nF3i4sIRv...

"Under psilocybin, expected image repetitions aberrantly recruited change-encoding ensembles and shifted cortical population dynamics towards trajectories normally evoked by genuine stimulus changes." www.biorxiv.org/content/10.6... (In mice)

🚨 Limited spots! 👉 🌈🧠 SfN Psychedelic Research Event 🌈🧠 Join us before #SfN2025 (Friday, Nov 14) for a deep dive into cross-species psychedelic neuroscience. Register + speaker profiles: 👉 hopkinspsychedelic.org/sfn2025 Posters, 🎤 panels, 🔑 keynotes,🍸 cocktails + 🥟 bites. #psychedelicresearch

created a website to convert any DOI to a elegant banner for presentations robertodf.github.io/doi-banner/

6/ Now on BioRxiv: Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise. t.co/Y8A4Su3rph #Psychedelics #Neuroscience #PsychedelicScience

5/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions. A huge thank-you to the entire OpenScope team, especially @jeromelecoq.bsky.social, for making this work possible!

4/ Unexpectedly, psilocybin's effect were not global or uniform but dependent on the image structure: Only images with long, continuous contours recruited change-encoding neurons that were modulated by psilocybin.

3/ Surprisingly, despite this oscillation, image id encoding was completely intact! By contrast, this oscillation was closely linked to CHANGE encoding, pushing visual cortex dynamics in SST interneurons towards states usually associated with surprise.

2/ We found a striking behavioral effect: psilocybin reduced change-detection performance to chance, without causing obvious motor deficits. At the same time, visual stimuli drove a strong 4-Hz oscillation across visual cortex, especially in VISp and SST interneurons.

#Psilocybin🍄 shifts visual cortex dynamics towards a state of surprise! Thrilled to share our work w/ OpenScope at @alleninstitute.org lead by postdoc @roberto-defilippo.bsky.social. We combined visual change detection w/ Neuropixels recordings in mice to uncover how psilocybin changes circuits 1/

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise https://www.biorxiv.org/content/10.64898/2026.08.21.745777v1

Two large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others. Should be a treasure trove of data for those interested in perceptual effects of #psychedelics www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...