Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise (in mice) www.biorxiv.org/content/10.6... by @roberto-defilippo.bsky.social @torbenottlab.org et al.

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise

Psilocybin profoundly alters visual perception, yet the neuronal mechanisms underlying these effects remain unclear. Here we combined large-scale Neuropixels recordings with cell-type-specific optogen...

biorxiv.org

"Under psilocybin, expected image repetitions aberrantly recruited change-encoding ensembles and shifted cortical population dynamics towards trajectories normally evoked by genuine stimulus changes." www.biorxiv.org/content/10.6... (In mice)

#Psilocybin🍄 shifts visual cortex dynamics towards a state of surprise! Thrilled to share our work w/ OpenScope at @alleninstitute.org lead by postdoc @roberto-defilippo.bsky.social. We combined visual change detection w/ Neuropixels recordings in mice to uncover how psilocybin changes circuits 1/

Two large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others. Should be a treasure trove of data for those interested in perceptual effects of #psychedelics www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

The belief that artificial consciousness is coming crucially depends on the assumption that consciousness is a computation. In this new paper, we'll try to convince you that consciousness cannot be a computation w Albert Gidon and M.Larkum www.frontiersin.org/journals/neu... #neuroAI #consci

Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

High-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.

science.org

www.nature.com/articles/s42...

Compositional pretraining improves computational efficiency and matches animal behaviour on complex tasks - Nature Machine Intelligence

Hocker et al. demonstrate a method for training recurrent neural networks, which they call ‘kindergarten curriculum learning’, involving pretraining on simple cognitive tasks to improve learning effic...

nature.com

Happy to share the latest version of our work on compositional maps in hippocampus with Jo Warren, @jcrwhittington.bsky.social, @behrenstimb.bsky.social. We propose hippocampus constructs maps from cortical building blocks in replay – now with empirical support! www.nature.com/articles/s41... 1/9

Constructing future behavior in the hippocampal formation through composition and replay - Nature Neuroscience

A model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.

nature.com

super excited that the first paper from my PhD is now out! we develop a "philosophical toolkit" for computational cognitive modeling & use it to conceptually re-analyze a long-standing debate about evidence accumulation models of decision making 🧠📈 onlinelibrary.wiley.com/doi/full/10....

Reasoning Goals and Representational Decisions in Computational Cognitive Neuroscience: Lessons From the Drift Diffusion Model

The appropriate form of the drift diffusion model depends on how one wishes to reason about their target with the model. If the goal is to parsimoniously explain the speed-accuracy tradeoff, the appr...

onlinelibrary.wiley.com

🤖🧠 Paper out in Nature Communications! 🧠🤖 Bayesian models can learn rapidly. Neural networks can handle messy, naturalistic data. How can we combine these strengths? Our answer: Use meta-learning to distill Bayesian priors into a neural network! www.nature.com/articles/s41... 1/n

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8) rdcu.be/el19t

Prefrontal encoding of an internal model for emotional inference

Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.

rdcu.be

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

🐦 Deadline tomorrow! Working in the decision-making field? Then you should definitely apply for the "Symposium on the Biology of Decision-Making" (SBDM25) in Lyon 🎥 Speakers include: @anna-beyeler.bsky.social @juliasliwa.bsky.social @torbenott.bsky.social @faurelab.bsky.social sbdm2025.github.io

*** Come join us !! We are recruiting !! *** How does the brain generate beliefs that go beyond direct experience? How do these mechanisms go awry in psychosis? The Barron lab tinyurl.com/bdf4drjf @MRCBNDU @NDCNOxford are recruiting a new postdoc tinyurl.com/ut4vbwt4 to work in mouse models

I'm excited to share that the last chapter of my PhD thesis is now published in Nature! 🍾 What drives serotonin neurons? We think it's the expectation of future reward and --- critically --- how fast this expectation is increasing. 📈 doi.org/10.1038/s415... 1/6

A prospective code for value in the serotonin system - Nature

Merging ideas from reinforcement learning theory with recent insights into the filtering properties of the dorsal raphe nucleus, a unifying perspective is found explaining why serotonin neurons are ac...

doi.org

"Academics tend to be averse to discussing mental health openly, and higher education’s mental health safety net is patchy—a forgotten footnote that all too often fails its students." #MentalHealthAwarenessMonth scim.ag/4m61iaU

Super interesting work with a computational model of how auditory hallucinations may arise: journals.plos.org/plosbiology/... #neuroscience #compneuro

Impaired motor-to-sensory transformation mediates auditory hallucinations

Can the absence of inhibition lead to auditory hallucinations? This study shows that the impairment of motor-based sensory predictions causes erroneous monitoring of imprecise internal auditory repres...

journals.plos.org

🎓 Join us for the International Postdoc–Junior PI Retreat! 📍 Neupitz, near Berlin 🗓️ Sept 1–3, 2025 Connect, collaborate & recharge with peers in nature. 🆓 Travel, stay & meals funded. 🔗 Apply by May 31: torbenottlab.org/postdoc-youn... With @jelenabrasanac.bsky.social

Do you want to analyse multidimensional large scale foraging data? I have a postdoc opening. Postdoc will be part of an HSFP grant ‘”Neurometabolic mechanisms underlying social foraging” with Robert Froemke (NYU) and Jee Hyun Choi (KIST). Details: stellen.uni-konstanz.de/jobposting/8...

Re-posting is appreciated: We have a fully funded PhD position in CMC lab @cmc-lab.bsky.social (at @tudresden_de). You can use forms.gle/qiAv5NZ871kv... to send your application and find more information. Deadline is April 30. Find more about CMC lab: cmclab.org and email me if you have questions.

🎓 Join us for the International Postdoc–Junior PI Retreat! 📍 Neupitz, near Berlin 🗓️ Sept 1–3, 2025 Connect, collaborate & recharge with peers in nature. 🆓 Travel, stay & meals funded. 🔗 Apply by May 31: torbenottlab.org/postdoc-youn...