Imagine you just refereed the World Cup then have the inglorious honour of having a fascist put a medal around your neck
Robert Screaton
@roblab.bsky.social
scientist. regeneration. mitochondria. diabetes. cancer. views my own.
that feeling you get when you delete all uber related apps from your phone
The home run derby aka who is the best at batting practice
Metabolic signatures that distinguish LADA, T1D link.springer.com/article/10.1...
Metabolomic profile differs between LADA and type 1 diabetes identifying tryptophan metabolism as a pathway involved in the heterogeneity of autoimmune diabetes - Diabetologia
Aims/hypothesis The heterogeneity of autoimmune diabetes may be associated with variable metabolic alterations. Our aim was to investigate differences in the metabolomic and lipidomic profile of autoi...
link.springer.com
thank you shane for a few innings of serviceable work this year but $16M for 7-0 down isn't what we had in mind #bluejays
"Curiosity-driven research is really the seed corn for the major breakthroughs and applications. But it’s also important in its own right, because discovery and the expansion of knowledge are virtues in themselves." Thanks @neilshubin.bsky.social (gift article) www.nytimes.com/2026/06/12/s...
Neil Shubin on Trusted Science in a ‘Deeply Partisan Age’
nytimes.com
Emoticons: E9.5 mouse embryo sections through otocyst, hindbrain and pharyngeal endoderm resemble eyes, nose, and smile of an emoticon. 📸 Image credit: Ankita Thawani (Baylor College of Medicine) #FluorescenceFriday #Embryology #DevelopmentalBiology #Microscopy #ScienceArt✨ 🧬
Not just a critique, an editorial that was published in the ADA's own flagship journal Diabetes Care. The experts included several past ADA Presidents and Award winners. Page views before the ADA publicized the editorial <300, approaching 10k now. Link below, let's help the ADA get the word out.
Brandon Friedman@brandonfriedman.bsky.social · 2mo agoA real headline in the United States today
Are there predictive T2D indicators in existing clinical data? Yes, thx to deep learning Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study - The Lancet Digital Health www.thelancet.com/journals/lan...
Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study
This study highlights the potential for using deep learning methods on longitudinal health data from both primary and secondary care to develop low-cost predictive tools for screening of young-onset t...
thelancet.com
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 www.science.org/doi/10.1126/...
Unstructured transcription factor interactions enable emergent specificity
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
science.org
Unreliable and underperforming antibodies are a longstanding problem, so while the reveal of apparently manipulated antibody data in Thermo Fisher's catalog was a shock, the frustration it sparked among many researchers is perhaps no surprise. My reporting:
Science sleuths uncover more than 100 suspicious images in Thermo Fisher antibody catalogue
Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.
nature.com
Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction. www.biorxiv.org/content/10.6...
biorxiv.org
CIHR has launched a trial ballon that suggests shifting to one competition a year. This is the worst idea I have heard in a long time. The only benefit is making top-line success rates look better than they are. Keep it as is, do in-person reviews, and keep the pain in the open.
springer needs not to be our leadoff hitter. lost the jays the game. #bluejays
if ever a fanbase that shows up at >40K per home game deserved better...
Keegan Matheson@keeganmatheson.bsky.social · 3mo agoThe #BlueJays have been walked off in Detroit, 3-2. They're 19-25.
link.springer.com/article/10.1...
ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice - Diabetologia
Aims/hypothesis Reactive oxygen species modulator 1 (ROMO1) is a highly conserved inner mitochondrial membrane protein that senses reactive oxygen species and regulates mitochondrial dynamics. ROMO1 i...
link.springer.com
CIRTN-R2FIC@cirtn.bsky.social · 3mo ago(🧵 1/22) Many publications from the CIRTN labs this Spring 🌷! Works are from Drs Bruin, MacDonald, Johnson, Mulvihill, Chen, Verchere, Kolic, Huang, Hull-Meichle, Kin, Shapiro, Korbutt, Pepper, P. MacDonald, T. MacDonald, Rideout, Riddell, Rutter, Rabasa-Lhoret and Prentice.
#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor
We’ve started an award for Best Lecture for the 2026 🇨🇦 National Grad Course in Islet Biology and Diabetes, voted on by the trainees (23 this year). The winners of the inaugural award [drum roll]..... @theodoreds.bsky.social and @chrisadoucette.bsky.social! Congratulations!
We had a masterclass today on the impact of human genetics in unraveling the mysteries of #T2D. Expert @annagloyn.bsky.social joined us to close out the 🇨🇦 National Graduate Course in Islet Biology and Diabetes for 2026!
Metabolism driving cell fate! TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency: Cell Stem Cell www.cell.com/cell-stem-ce...
TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency
Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...
cell.com
Today in the 🇨🇦 National Grad Course in Islet Biology and Diabetes we are joined by experts @ejrideout.bsky.social and Jee Yeon Cha (Vanderbilt U) to discuss sex-dependent phenotypes and responses in chronic disease, autoimmunity, and diabetes. A dynamic lecture for a dynamic field!
a man in a suit and tie is standing in a doorway with the words it 's go time .
ALT: a man in a suit and tie is standing in a doorway with the words it 's go time .
media.tenor.com
All scientists are different but one thing that every successful scientist has in common is an intense, almost obsessive passion to know how things work... 1/2
link.springer.com/article/10.1... New targets for intervention in T1D
Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes - Diabetologia
Aims/hypothesis Although genome-wide association studies (GWAS) have identified loci associated with type 1 diabetes, the specific pathways and regulatory networks linking these loci to disease pathol...
link.springer.com
link.springer.com/article/10.1... New article from the group on the effects of aging and sex in beta cell glucose sensing - ROMO1 and complex II! Thanks to funders @diabetescanada.bsky.social and CIHR.
ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice - Diabetologia
Aims/hypothesis Reactive oxygen species modulator 1 (ROMO1) is a highly conserved inner mitochondrial membrane protein that senses reactive oxygen species and regulates mitochondrial dynamics. ROMO1 i...
link.springer.com
Today in the 🇨🇦 grad course in islet biology and diabetes we are joined by experts @rlhull-meichle.bsky.social and @teresamastracci.bsky.social for a discussion of context and cues: islets in a sea of acini!
a man in a wetsuit is floating in the ocean with his hand up
ALT: a man in a wetsuit is floating in the ocean with his hand up
media.tenor.com
Asked AI to draw an icon to represent the concept of "transplant". Stay in school, AI.
Tell me you've written a CIHR grant without telling me you've written a CIHR grant www.instagram.com/reel/DW9gCDN...
Jess and Quinn on Instagram: "One year ago✨"
1M likes, 4,308 comments - jessandquinn on April 10, 2026: "One year ago✨".
instagram.com