Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social

Ronny Helman@ronnyhelman.bsky.social · last yr.

Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports. Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...

Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports. Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by the same signals that trigger insulin secretion. This activation, in turn, inhibits insulin release via RhoA-dependent...

cell.com