Mike Kalwat
@kalwat.bsky.social
enjoying #heavy_metal and figuring out how #beta_cells work #hypersecretion #T1D #T2D #HI
I'm raising money for Breakthrough T1D (new name for JDRF) to change the lives of people with type 1 diabetes. We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms. p.bt1d.org/7ujvl
Support my Breakthrough T1D Walk
Learn why I'm participating in the Breakthrough T1D Walk and raising funds to help create a world without type 1 diabetes (T1D).
p.bt1d.org
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Worried Northwestern lab directors describe ‘bleak’ atmosphere in wake of Trump research funding freeze
The Trump administration’s freezing of $790 million in federal research funding for Northwestern University has left concerned lab directors without key grants and forced the university to spend mi…
chicagotribune.com
Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social
Ronny Helman@ronnyhelman.bsky.social · last yr.Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports. Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science. www.ascb.org/science-poli...
NIH Research Funding at Risk—Take Action Now! - ASCB
Along with supporting important scientific discoveries, federally funded scientific research has significant impact on state and local economies. It is estimated that, on average, every $1 of National...
ascb.org
Paradoxically, both GIPR agonism and antagonism potentiate weight loss when paired with GLP-1R agonism. Two new studies in @natmetabolism.nature.com decode the different neural mechanisms employed by each strategy. Check out the #News&Views by @adriaenssenslab.bsky.social here.
Nature Metabolism@natmetabolism.nature.com · last yr.
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23. Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top: www.federalregister.gov/documents/20... 6/n
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
federalregister.gov
NIH is the best investment there is. www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
forbes.com
Just posting this starter pack for #PancSky again as I have added more people - let me know any other islet/pancreas scientists I've missed! go.bsky.app/3wdSpdi
Hey #PancSky and #islet people, we're hosting the 2025 Midwest Islet Club in Indianapolis May 7-8. Most of the talks are from students/postdocs. Help spread the word about abstract submission and registration! medicine.iu.edu/research-cen...
2025 Midwest Islet Club Meeting | Center for Diabetes and Metabolic Diseases | IU School of MedicineIndiana University School of MedicineFacebookInstagramLinkedInTwitterIndiana University School of Me...
medicine.iu.edu
Breaking: FDA's March meeting to select flu shot strains for 2025-2026 season has been canceled per email sent to committee members, a VRBPAC member told me. drug companies need about 6 months leeway to make shots in time for fall vax campaigns. #healthpolicy
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
npr.org
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at: 5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Streamlit
mssearch.xyz
I don't think IIDP is on Bluesky yet, so just reposting. iidp.coh.org/funding Applications Due: February 14, 2025. #islet #PancSky
Reminder: You can always submit a grant late and include a cover letter saying why. NIH receipt and referral may take it. Or not. If you end up missing deadline because of these Commons access issues, there is this potential save move.
New preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by @marcellharhai.bsky.social @fbm-unil.bsky.social A short thread 1/5 www.biorxiv.org/content/10.1...
Will be very interesting to see how molecular biology changes in the next decade with these types of advances.
Eric Topol@erictopol.bsky.social · 2y agoWhoa! When a large language of life model generates a protein equivalent to ~500 million years of evolution. @science.org science.org/doi/10.1126/...
Re-upping this paper which is ‘out’ now in this month’s issue of Cell Metab. Working with a fantastic group of collaborators, we provide a resource for exploring human islet variation in health and diabetes. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00365-6
Happy to finally have this preprint up which represents a lot of effort from first author Gitanjali Roy and important contributions from multiple labs. I hope this work enables the discovery of cool beta cell biology related to hypersecretion.
bioRxivpreprint@biorxivpreprint.bsky.social · 2y agoTarget deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells https://www.biorxiv.org/content/10.1101/2024.12.26.629558v1
Our undergrad interns in my lab at IBRI, Rachel Kuntz (#UROP) and Ini Aduroshakin (#LHSI), presented a few weeks back at the Indiana University Indianapolis Undergrad Research Conference! Rachel won an honorable mention for her poster! Thanks Andrea John and Tom Stucky for organizing.
Nobel Laureates Urge Senate to Turn Down Kennedy’s Nomination Elevating Mr. Kennedy to secretary of H.H.S. “would put the public’s health in jeopardy,” more than 75 laureates wrote. www.nytimes.com/2024/12/09/h...
Nobel Laureates Urge Senate to Turn Down Kennedy’s Nomination
Elevating Mr. Kennedy to secretary of H.H.S. “would put the public’s health in jeopardy,” more than 75 laureates wrote.
nytimes.com