The peer-reviewed version: www.science.org/doi/10.1126/...

Enteric viral infections promote systemic accelerated aging in Drosophila

Enteric viruses act as age-distorters, with infection severity tied to aging hallmarks and consequences.

science.org

Rubén González@rubengonzalez.bsky.social · 9mo ago

Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms. www.biorxiv.org/content/10.1...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

The conference is quickly filling up! Don't wait to sign up. We also received some funding and can offer fellowships to graduate students and postdocs. Won't cover the whole cost but will certainly make it much easier!

Dmitri Petrov@petrovadmitri.bsky.social · 6mo ago

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...

Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

nature.com

🔬 Discover the latest advances from Labex IBEID We have released a new white paper highlighting recent scientific and technological advances from the partners. ➡️ Key results ➡️ Latest innovations ➡️ Future challenges for Emerging Infectious Diseases research www.labexibeid.fr/en/ibeid-whi...

Not all bacteria are beneficial in every context. We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage. rdcu.be/eZ4Sd

We just uploaded our most recent paper to @biorxivpreprint.bsky.social and submitted the manuscript for publication. We are really excited with this collaboration between our lab (ColladoLab) @cimususc.bsky.social and the lab of @hanli-pasteur.bsky.social @pasteur.fr

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

SENOMORPHIC EFFECT OF GENETIC AND CHEMICAL PARTIAL REPROGRAMMING https://www.biorxiv.org/content/10.64898/2026.01.13.699211v1

Kicking off 2026 the best way we know how: together! 🥐👑 Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉 But the real treasure? These moments that unite us before another year of discovery. Here's to an incredible 2026! 🔬✨

If you want to help, you can share our story, check out our work at viralemergence.org, and - if you're the one in a million person who can save our project - reach out. (At this point, my job is to fundraise for the amazing scientists I work with, so they can focus on doing some actual science! 🦠)

Verena

Verena is an NSF-funded Institute working towards using open data, biological research, and artificial intelligence to predict and prevent the next pandemic.

viralemergence.org

Now published as version of record at @elife.bsky.social ! Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️) elifesciences.org/articles/107... shop.vbc.ac.at/vdrc_store/d... #Drosophila #IDsky #SymbioSky #Infection #Immunology

Mark A. Hanson@hansonmark.bsky.social · last yr.

Excited to finally announce this work which has been in the pipeline for 5 years: Layers of Immunity. Faustine et al. made a set of immune mutants covering 4 major immune modules in #Drosophila, deleting melanization (ROS), phagocytosis, and both Toll & Imd NF-kB responses. What did we find? 1/n 🧵

All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e

Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms. www.biorxiv.org/content/10.1...

Enteric viral infections promote systemic accelerated aging in Drosophila

Do viral infections accelerate aging, and does this acceleration scale with pathogenicity? Using transcriptomic aging clocks, we measured biological age in Drosophila infected with four enteric RNA vi...

biorxiv.org

Rubén González@rubengonzalez.bsky.social · last yr.

In my first Drosophila study at @salehlabparis.bsky.social, we found that: 1. Enteric viral infections accelerate aging. 2. Even if the infection is cleared, aging process remains triggered. 3. Accelerated aging correlates with reduced lifespan. 📑Preprint: www.biorxiv.org/content/10.1...

In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals. #Aging #Infection #MicroSky #Virology 📖 shorturl.at/OeYVp ✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social @salehlabparis.bsky.social @pasteur.fr

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄 A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think. Our at-scale AI structure prediction gave a complementary perspective on viral evolution. www.nature.com/articles/s41...

Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology

Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

nature.com

Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…

Tomer Ullman@tomerullman.bsky.social · 9mo ago

Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

FlyBase secures funding for year, but future still uncertain

The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

tinyurl.com

Last chance to download my book for free! It's still available until tomorrow.

The Ramsey Lab@theramseylab.bsky.social · 10mo ago

New Element in the Philosophy of Biology series—free to download until Oct. 24! @djnicholson.bsky.social uncovers Schrödinger’s motivations for writing "What Is Life?", revisits its central arguments & examines the book’s lasting impact on cell & molecular biology👇 www.cambridge.org/core/element...

What makes PhD students happy? Good supervision www.nature.com/articles/d41...

What makes PhD students happy? Good supervision

Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

nature.com

Science is so much fun!

Mauro Castelló Sanjuán@castellosanjuan.bsky.social · 10mo ago

(3/5) But first, I wanna share some sneak peeks of how this work has come to be, how I made the lab home, and the bonding that comes with working closely:

I'm so excited to share this with all of you! This is the very first paper where I am the first author 🥹 Let me share some insights about our work 👇🧵(1/5): How do persistent viral infections impact the host? What happens when a fly becomes persistently infected by a virus?

Microbiome composition modulates the lethal outcome of Drosophila A virus infection https://www.biorxiv.org/content/10.1101/2025.10.16.682821v1

🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results Explore Plasmidsaurus RNA-Seq today.

1/3 What happens when a fly gets persistently infected by a virus? In our latest work, we established persistent infections to examine their impact on this model organism. By tracking four natural, persistent RNA viruses...

Dear JEDIs, as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to katja.rust@uni-marburg.de to be added to our database. #Drosophila @fly-eds.bsky.social

Cheaper defense first, costly one later. This makes sense. journals.plos.org/plosbiology/...

Plants respond to herbivory through sequential induction of cheaper defenses before more costly ones

Plants encounter natural threats of varying intensity and respond by activating multiple defense traits. This study of six defense traits in Ambrosia artemisiifolia reveals that when attacked by insec...

journals.plos.org

Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...

Matthew Cobb@matthewcobb.bsky.social · 11mo ago

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

if you have your team and grants, not forget to support @flybase.bsky.social www.philanthropy.cam.ac.uk/give-to-camb... meanwhile, we need to think longterm and protect this data, dl it, share it portal.datarescueproject.org/datasets/fly...

The 2025-26 Eco-Evo job list is out. Good luck to those applying! docs.google.com/spreadsheets...

ecoevojobs.net 2025-26

docs.google.com