Interrogating the Carboxylation of Potassium β-Diketonates and β-Diketiminates by Carbon Dioxide

Enolate carboxylation by CO2 is essential to applications ranging from polymer synthesis to CO2 capture, yet the CO2 reactivity of stabilized enolates, such as β-dicarbonyl enolates, remains understud...

pubs.acs.org

Meet the ACS National Award winners for 2026

Recipients are recognized for significant contributions to chemistry and the chemistry community

cen.acs.org

Caging the Chlorine Radical: Chemoselective Photocatalytic C(sp3)–H Functionalization Enabled by Terminal Cu–Cl Sites in a Metal–Organic Framework

Hydrogen atom transfer (HAT) mediated by halogen radicals represents a powerful approach for the functionalization of inert C(sp3)–H bonds. Chlorine radical (Cl•), for example, is capable of generatin...

pubs.acs.org

Photochemical Fluoroalkylations with Fluorinated Gases Facilitated by a Robust Metal–Organic Framework

Photochemistry has greatly advanced the sustainable synthesis of complex molecules, but its application for late-stage fluoroalkylation─crucial due to the presence of fluorine in >20% of pharmaceuticals and >65% of agrochemicals─is hindered by the poor atom economy of traditional fluoroalkylating agents. Herein, we demonstrate that simple fluorinated gases, which represent ideal building blocks for fluorochemical synthesis, can be stored within the robust, inexpensive, and redox-innocent metal–organic framework Al–fum to streamline the development of 11 photoinduced fluoroalkylation reactions, including bimolecular homolytic substitution (SH2), metallophotoredox cross-coupling, and [2+2] cycloaddition reactions. The gas–Al–fum reagents are prepared via simple gas-dosing procedures, stable for several months in a desiccator at room temperature, and are compatible with reaction optimization campaigns and mechanistic studies using precise quantities of gases. Overall, our findings provide a general platform for the utilization of inexpensive gaseous building blocks in photochemistry, paving the way for the sustainable synthesis of next-generation fluorochemicals.

pubs.acs.org

Interrogating the Carboxylation of β-Diketonates and β-Diketiminates by Carbon Dioxide

Enolate carboxylation by CO2 is essential to applications ranging from polymer synthesis to CO2 capture, yet the CO2-reactivity of stabilized enolates, such as β-dicarbonyl enolates, remains understud...

chemrxiv.org

The 2025 chemistry Nobel goes to MOFs

Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

cen.acs.org

Dynamic Evolution from Single-Atom Catalysts to Active Nanograins for CO2 Reduction

Understanding dynamic catalyst evolution, particularly Cu-based single-atom catalysts, faces tremendous challenges of tracking rapid and nanoscale evolution and uncontrolled catalyst reoxidation durin...

pubs.acs.org

Polymer connectivity governs electrophotocatalytic activity in the solid state - Nature Chemistry

The combination of electricity and light can provide a sustainable route to drive challenging synthetic transformations, but current catalysts are plagued by poor stability and mechanistic ambiguity. ...

nature.com

Defluorinative Coupling of (NH)-Heteroarenes and Unactivated Vinyl Fluorides Enabled by Metal–Organic Frameworks

N-vinyl azoles are prevalent moieties in pharmaceuticals, and fluorovinyl groups are widely recognized as carbonyl bioisosteres in drug design. Thus, N-fluorovinylated heteroarenes represent highly de...

pubs.acs.org

ACS announces 2026 national award winners

The winners are being acknowledged for their outstanding achievements in chemistry across various fields in the discipline

cen.acs.org

Polymer connectivity governs electrophotocatalytic activity in the solid state

Nature Chemistry - The combination of electricity and light can provide a sustainable route to drive challenging synthetic transformations, but current catalysts are plagued by poor stability and...

rdcu.be

‘Breakthrough Science’ grant supports disease-targeting lipid research | Cornell Chronicle

A grant from the Ono Pharma Breakthrough Science Initiative, which supports bold new ideas in science, will help Cornell researchers study how chemical modifications to proteins play a powerful role i...

news.cornell.edu

Graduate Field Coordinator-Department of Chemistry and Chemical Biology

Graduate Field Coordinator-Department of Chemistry and Chemical Biology The Opportunity The Department of Chemistry and Chemical Biology is seeking a dedicated and detail-oriented Graduate Field Coord...

cornell.wd1.myworkdayjobs.com

Public Access Policy | Data SharingA locked padlock

Public Access Policy | Data Sharing - Learn about NIH data sharing policies and how to share and access scientific data

sharing.nih.gov

Amine oxides step up - Nature Energy

Nature Energy - Amine oxides step up

nature.com

Controlled Growth and Interconversion of Photoluminescent Metal–Organic Frameworks under High-Concentration Conditions

A major drawback to the implementation of metal–organic frameworks (MOFs) on scale is the vast quantity of organic solvents, typically N,N-dimethylformamide (DMF), required to synthesize even small qu...

pubs.acs.org