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Ruoyan Li

@ruoyanli89.bsky.social

Assistant Professor at MD Anderson Cancer Center | Cancer genomics, single-cell genomics, and somatic evolution https://www.mdanderson.org/research/departments-labs-institutes/labs/ruoyan-li-laboratory.html

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Kamila Naxerova@naxerova.bsky.social · 4mo ago

A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution? Postdoc D. Cheek had the creative idea to use patient ages to try and answer this question. Read new paper out here: www.nature.com/articles/s41...

Age distinguishes selection from causation in cancer genomes - Nature Genetics

Mutations may be enriched in tumor samples because they promote carcinogenesis or because they promote clonal expansions in healthy tissue. This study mathematically disentangles these two possibiliti...

nature.com

Tianshu@tianshu-sun.bsky.social · last yr.

Excited to share that our latest work in New Phytologist: the first cell-type–resolved transcriptomic atlas for two dicot C4 models (G. gynandra & F. bidentis) with a single-protoplast vs single-nucleus comparison + an interactive gene-expression browser. nph.onlinelibrary.wiley.com/doi/10.1111/...

Conserved spatial patterning of gene expression in independent lineages of C4 plants

C4 photosynthesis enhances carbon fixation efficiency by reducing photorespiration through the use of an oxygen-insensitive carboxylase and spatial separation of photosynthesis between mesophyll and ....

nph.onlinelibrary.wiley.com

Inigo Martincorena@imartincorena.bsky.social · 2y ago

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Somatic mutation and selection at epidemiological scale

As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

medrxiv.org