In @jcb.org, Bharathan, Kowalczyk et al. provide the first comprehensive description of the 3D desmosome in A431 epidermoid carcinoma, human mammary epithelial cells, and airway epithelia in volume electron microscopy datasets. rupress.org/jcb/article/... #Adhesion #StructuralBiology

In @jcb.org, Olivia P.L. Dalby, Sabrina Simoncelli et al. @ucl.ac.uk use super-resolution imaging and reveal that CAR-T cells assemble immunological synapses with distinct actin architectures, including reduced central clearance and enhanced protrusions. rupress.org/jcb/article/... #Immunology

In @jem.org, Berzosa, @basicleukocyte.bsky.social, Malinova et al. identify SorLA as a key regulator of B cell receptor trafficking, which binds immunoglobulin and controls endosomal sorting. rupress.org/jem/article/... 🎥 Short video summary by McShane: youtu.be/O0v87xz-Bik

In @jcb.org, Myeong and Klyachko demonstrate that astrocytic cholesterol release modulates synaptic transmission in an activity-dependent manner to fine-tune the balance and spatial organization of different forms of synaptic exo- and endocytosis. rupress.org/jcb/article/... #Neuroscience

In a new @jhumimmunity.org review on DADA2, Wouters et al. cover the full spectrum of disease (#vasculitis, bone marrow failure, #immunodeficiency), TNF inhibitors, stem cell transplant, & #genetherapy on the horizon, the concept that a single variant can cause disease. rupress.org/jhi/article/...

In @jhumimmunity.org, Lamah et al. identify three novel mutations in AIRE and detect T cell defects in patients with APS-1. Furthermore, they review the literature and identify additional clinical features, and define mutational hotspots suitable for targeted sequencing rupress.org/jhi/article/...

In @jcb.org, Liffner, @sabsalon.bsky.social et al. apply Mosquito Tissue Ultrastructure Expansion Microscopy to reveal previously inaccessible details of #Plasmodium sporozoite formation and salivary gland invasion. rupress.org/jcb/article/... #Organelles #Microbiology #CelDivision #Malaria

On the cover of @jem.org's August issue (rupress.org/jem/issue/22...): Light-sheet fluorescence microscopy reveals spatial distribution of intracerebroventricularly infused ovalbumin (OVA) in an optically cleared whole mouse head. (Yan et al. rupress.org/jem/article/...)

@jcb.org's August cover (rupress.org/jcb/issue/22...) shows an immunofluorescence image of LX-2 cells acquired using a Leica Stellaris confocal microscope. Blue, DAPI (DNA); green, type-I collagen, α-1 chain; magenta, TANGO1 (ER exit sites). Bhattacharyya et al. @crg.eu: rupress.org/jcb/article/...

New Commentary @jgp.org: Zhang Feng discusses a new study from Stephens et al. (rupress.org/jgp/article/... ) showing how a hydrophobic interaction network between TM3 and TM4 stabilizes an ion-conductive conformation of the TMEM16A chloride channel. rupress.org/jgp/article/... #IonChannels

New @jcb.org review: Yamada, Cruz Walma & Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis & #cancer. rupress.org/jcb/article/...

Giardino et al report the first detailed immunological characterization of a DEGCAGS patient, showing that biallelic ZNF699 loss-of-function variants can cause syndromic combined #immunodeficiency & DNA methylation profiling improves diagnostic precision in selected #IEIs rupress.org/jhi/article/...

Melzer highlights new @jgp.org study from Rios and Pizarro (rupress.org/jgp/article/... ) which simulates allosteric interactions within the couplon using Markov chain modelling to successfully describe many characteristics of whole-cell and microdomain Ca2+ signals. rupress.org/jgp/article/...

In @jcb.org, Zhenjie Wang, Zhe Feng et al. uncover the molecular basis of Ana1-driven #centriole elongation in #Drosophila #spermatogenesis, showing that Ana1/CEP295 promotes longitudinal centriole extension through direct interactions with both Cep135 and #microtubules. rupress.org/jcb/article/...

In a recent @jcb.org study, Izumi and Furuse (rupress.org/jcb/article/...) uncovered an unexpected signaling function for cell-cell #adhesion proteins in maintaining tissue homeostasis. More from the National Institute for Physiological Sciences, Japan:

Keeping Stem Cells in Check A New Mechanism by Which Cell Junction Proteins Regulate Tissue Homeostasis

Researchers have discovered that smooth septate junction proteins regulate intestinal stem cell prolifera

nips.ac.jp

In @jcb.org, @georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al reveal that RAD51C is anchored at the Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...

APDS is a rare inborn error of immunity classified as a group of combined #immunodeficiency; however, Kanegane et al. show that, because specific treatments for APDS are available, early diagnosis and therapeutic intervention are crucial for improving patient prognosis. rupress.org/jhi/article/...

In @jcb.org, Bhaskar Naidu, Vera Lillo, Manneville, Miserey, Campelo @bist.eu et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...

Hematopoietic stem cell transplantation is a curative option for children w/ MSMD. In @jhumimmunity.org, Ganesan et al. show that outcomes improve when conditioning is tailored to genetic defects: Flu/Treo for IL-12 deficiency & Flu/Treo/TT w/ pretransplant immunosuppression for IFN-γ defects.

In @jcb.org, Janssen, Angulo-Urarte, et al. @huveneerslab.bsky.social @uva.nl show that nanoscale membrane curvatures at asymmetric endothelial cell–cell junctions serve as a scaffold to recruit BAR proteins, including BIN1 and SNX9, during collective migration. rupress.org/jcb/article/...

In @jem.org, Nakul M. Shah and Funda Meric-Bernstam review the rapidly evolving landscape of antibody–drug conjugates for #SolidTumors. The authors evaluate major design components, clinical efficacy of approved agents, and determinants of response and resistance. rupress.org/jem/article/...

Does CVID exist in children? In @jhumimmunity.org, @esidsociety.bsky.social registry analysis of 7,525 CVID patients shows age-dependent enrichment of monogenic #IEI in pediatric & early-onset CVID-like disease, supporting genetic testing and longitudinal reassessment. rupress.org/jhi/article/...

In @jcb.org, Gierke, Gadomska, Brandstätter et al. @fau.de show that the synaptic ribbon-associated protein Piccolino is essential for synaptic vesicle tethering at sensory synapses, and propose a direct protein–lipid interaction as the underlying molecular mechanism. rupress.org/jcb/article/...

In @jcb.org, Mori, Ohtsuka et al. demonstrate that the presynaptic active zone proteins CAST and ELKS directly interact with endophilin-A to maintain the functional synaptic vesicle pool, redefining their roles beyond structural organization. rupress.org/jcb/article/... #Neuroscience #Trafficking

In @jcb.org, Saiduddin, @remlehmann.bsky.social et al. @whiteheadinstitute.bsky.social @mit.edu show that membrane lipid composition establishes the soma-germline boundary in the fly embryo. rupress.org/jcb/article/... #Drosophila #CellSignaling #StemCells

Insights @jem.org: Choi et al. (rupress.org/jem/article/...) identify a downstream tPA–LRP1 axis that safeguards the renal epithelium during systemic #candidiasis, revealing a mechanism by which IL-17 preserves organ integrity. Michail Lionakis highlights the findings: rupress.org/jem/article/...

This case report @jhumimmunity.org from Shin, Lyons et al. describes progressive multifocal leukoencephalopathy in a patient with ADA-#SCID who received early #GeneTherapy, highlighting the importance of lifelong monitoring after early gene therapy protocols. rupress.org/jhi/article/...

Half of muscle RyR channels lack voltage sensor contact-so how do they activate? New model in @jgp.org from Rios and Pizarro shows that allosteric propagation through the couplon explains it all. rupress.org/jgp/article/... #Biophysics #IonChannels #ComputationalBiology #SkeletalMuscle

In @jem.org, Wonseok Choi, Partha S. Biswas et al. show that tissue-type plasminogen activator protects against kidney damage, thereby highlighting a previously unrecognized tissue-protective signaling pathway that mitigates organ damage during #candidiasis. rupress.org/jem/article/...

In @jgp.org, Howell, Xu, & Cohen (@harvard.edu) provide a framework for predicting & interpreting bioelectrical dynamics in small structures, such as bacteria, viruses, & intracellular vesicles, where they are strongly affected by stochastic gating of single #ionchannels. rupress.org/jgp/article/...