Sahil Batra
@sahilbatra.bsky.social
Structural Biologist studying DNA replication Nature enthusiast
Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology... www.mskcc.org/news/cryo-el...
Cryo-Electron Microscopy Reveals Hidden Mechanics of DNA Replication, Sheds New Light on Cancer Target
MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer.
mskcc.org
Thrilled to share first part of my post-doc work, published today in @science.org www.science.org/doi/10.1126/... We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
science.org