If you have experience in biochemistry/cryo-EM, are interested in DNA replication, and would like to do a postdoc in New York - our lab has positions available! Just DM or email me with your CV.

Our lab is hiring! As our fierce technician is moving on to graduate school (GO ANNA!), we’re looking for a new tech to join our team studying bacteria-phage interactions. Ideal for recent grads interested in molecular biology and microbiology - please reach out with a CV to aviramn@mskcc.org.

Happy to share our perspective on the DNA translocation mechanism by the CMG helicase. DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology

Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

nature.com

Hello everybody, I am looking for an Engineer (IE) to help me start the lab at LBMC / ENS-Lyon in April. We will investigate chromatin organization during replication in yeast. RT appreciated! To apply: inserm.softy.pro/offre/187863 @lbmcinlyon.bsky.social #NewPI #3DGenome #chromatin #replication

Hi all! We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids. www.biorxiv.org/content/10.6... #3DGenome #chromatin #Cohesin #centromere

CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids

Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...

biorxiv.org

@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

Chromatin buffers torsional stress during transcription

During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...

science.org

Hi all ! Happy to share that I will open a lab at the LBMC at ENS-Lyon thanks to the #ATIP-Avenir funding. We will investigate the role the 3D chromatin organization in Replication and Repair. www.ens-lyon.fr/LBMC/equipes...

 Job offers out soon! #NewPI #3DGenome #chromatin #replication

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Support a New York State Biomedical Institute for a Healthier, More Affordable Future

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please look here for more information about a postdoc position careers.mskcc.org/vacancies/93...

93229-Postdoctoral Researcher – Laboratory of Max Wilkinson | Memorial Sloan Kettering Cancer Center

careers.mskcc.org

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Wilkinson Lab

We discover and study reverse transcriptases

wilkinsonlab.bio

Great work from Michelle Wang’s group at Cornell exploring how RNAP II and associated R-loops act as intrinsic roadblocks during mechanical DNA unzipping. These findings have mechanistic implications for transcription–replication conflict. rdcu.be/eILVd

RNA polymerase II is a polar roadblock to a progressing DNA fork

Nature Communications - Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the...

rdcu.be

Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social

The Rockefeller University @rockefeller.edu · 11mo ago

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

nature.com

Just out: BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function | PNAS www.pnas.org/doi/10.1073/... @mskcancercenter.bsky.social @kyriepappas.bsky.social #SawyersLabMSKCC

If you have not already, make sure to check out two fantastic recent preprints from the Patel and Wang labs on the same topic investigated using magnetic tweezers and angular optical trapping: doi.org/10.1101/2024... and doi.org/10.1101/2024...

Torsion is a Dynamic Regulator of DNA Replication Stalling and Reactivation

The inherent helical structure of DNA dictates that a replisome must rotate relative to DNA during replication, presenting inevitable topological challenges to replication. However, little is known ab...

doi.org

🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by thomasmretzer.bsky.social and Hamdan Lab! tinyurl.com/replisomerot...

Real-time imaging of rotation during synthesis by the replisome

During chromosome replication, unwinding by the helicase and synthesis by the polymerases can lead to overwinding and supercoiling of DNA. The mechanical consequences of these events and resulting loc...

tinyurl.com

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells

Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...

cell.com

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

sciencedirect.com

Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology... www.mskcc.org/news/cryo-el...

Cryo-Electron Microscopy Reveals Hidden Mechanics of DNA Replication, Sheds New Light on Cancer Target

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer.

mskcc.org

In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here: www.biorxiv.org/content/10.1...

Thrilled to share first part of my post-doc work, published today in @science.org www.science.org/doi/10.1126/... We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

science.org

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

science.org

I am so proud to share a major part of my graduate school research, published today in Science, where we use cell-free replication assays and cryo-EM to describe a central mechanism of eukaryotic DNA replication: www.science.org/doi/10.1126/...

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

science.org

MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉 MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...

America's Greatest Workplaces for Inclusion & Diversity 2025

Newsweek is partnering with Plant-A Insights Group to honor America's Greatest Workplaces for Inclusion & Diversity 2025. These companies are committed to fostering an inclusive and diverse work envir...

newsweek.com

In the midst of all the NIH & NSF chaos, I want to take a moment to focus on some good news and talk about science! 🧬✨ 🚨 New preprint alert! 🚨 doi.org/10.1101/2025... 🧵👇 (1/)

Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.

Marcel Werner@marcelwerner.bsky.social · last yr.

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering: www.biorxiv.org/content/10.1...

Setting up shop in advance of closing our profile on X.