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Saira Butt, MD

@sairabt.bsky.social

#IDsky #idboardreview #idmeded #meded #infectiousDiseases faculty at Indiana University #idfellowship program director

308 Posts1593 Follower721 Folgt
Saira Butt, MD@sairabt.bsky.social · 6mo ago

#CROI2025 #idsky Twice-Daily Dolutegravir With a 4-Month Rifapentine-Based Regimen for HIV-Associated Tuberculosis presented by Sean Wasserman: -DTG clearance markedly increased by RPT 1200mg co-administration -DTG bid dosing with RPT-based TB tx: therapeutic, safe, achieved Viral suppression

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#CROI2026 #idsky Efficacy & Safety of Bulevirtide (BLV) 2 or 10 mg in Chronic Hepatitis Delta (CHD) Including Patients With HIV/HBV: MYR301 Final Results presented by David Wyles. Long term BLV monotherapy for CHD for upto144wks was safe/effective (higher rates of undetectable virus w/10mg dose. 1/

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#croi2026 Hepatitis B Reactivation/Infection in People With HIV on Tenofovir-Sparing Antiretroviral Therapy presented by Grace Haser (UCSF): 1/ #idsky -Complete HBV serologies were not available prior to TXF sparing ART switch in 29% of cohort -HBV reactivation (r/i) rare (0.4%)

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#CROI2026 #idsky Metabolic Syndrome & Cognitive Impairment Among Men With & Without HIV: presented by Sara Hockney (Northwestern U): Age >65 dominant predictor; stronger effect #PWH. Metabolic syndrome not independently associated with cognition. Age>65+Metabolic syndrome highest overall impairment

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#croi2026 #idsky Implants Releasing NRTTI MK-8591 Fail to Protect Macaques Against SHIV Containing the M184V Mutation, presented by Charles Dobard. Findings highlight potential vulnerability of single-agent PrEP with agents that share resistance pathways with ART commonly used for treatment. 1/

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#croi2026 #idsky presented by Armando Espinosa Ortiz/Univ of Montreal: Bacteria specific CD4 T cells are depleted during untreated HIV & only partially restored with ART. There is phenotypic drift of these cells towards cytotoxic phenotype, which has been linked to HIV persistence. 1/

Saira Butt, MD@sairabt.bsky.social · 6mo ago

#croi2026 #idsky #hivsky Plenary by Ilesh Jani: Uneven progress: decline in 40% of new HIV infections globally (2010-2024) with uneven progress between regions. Appox 21 million lives saved by 2022 (54% decline in deaths). Unmet needs ART: East/south Africa 36%. Not on path to 2030 target

@id-journal.bsky.social · 8mo ago

29 IE pts (72%♂, mean 67y), 76% met POET criteria; oral abx after ~15d IV, 26d oral; 3 adverse outcomes (2 embolic, 1 death); linezolid common but caused changes in 6 pts.⚕️ #idsky

O04 Oral antimicrobial therapy for infective endocarditis: real-world experience from a teaching hospital in Scotland

Treatment of infective endocarditis with oral antibiotics is not common in the UK despite an evidence base supporting this approach in appropriate patients. From late 2022 onwards the Infection Unit in Ninewells Hospital, Dundee, has adopted the use of oral antibiotic therapy in the treatment of selected patients with infective endocarditis.ObjectivesWe aimed to review the clinical efficacy and outcomes in patients treated with oral antimicrobial therapy for infective endocarditis in our unit.MethodsWe retrospectively reviewed patients treated with oral antimicrobial therapy for infective endocarditis. Patient records were reviewed for basic demographics, endocarditis characteristics and treatment (both IV and oral). Adverse outcomes (defined as all-cause mortality, unplanned cardiac surgery, recurrence of bacteraemia or embolic events) were assessed for within 6 months of completion of therapy.ResultsIn total 29 patients were identified, of which 21 (72%) were male. Mean age was 67 (range 36-94). Of the patients included, 20 were classed as ‘definite’ endocarditis by Duke-ISCVID 2023 criteria, with the remaining 9 meeting ‘possible’ Duke-ISCVID 2023 criteria. Structures involved included aortic valve (15 patients), mitral valve (11 patients), ICED (2 patients) and tricuspid valve (1 patient), with 9 of the 27 valve infections occurring in prosthetic valves. In total, 15 of 29 (52%) patients had moderate to severe valvular regurgitation, 5 (17%) patients had a vegetation of 10mm or greater and 4 patients underwent surgery during the course of their illness. With regards to microbiology, our cohort included 14 patients with Streptococcus spp., 12 patients with Staphylococcus aureus (all MSSA), 2 patients with Enterococcus faecalis and one patient with coagulase-negative Staphylococcus spp. Mean peak C-reactive protein was 163 mg/L (range 17–400) with mean C-reactive protein at transition to oral therapy of 21 mg/L (range 3–98). In total, 22 patients (76%) met the criteria used in the POET trial. Mean duration of IV therapy was 15 days (range 6–30). Mean duration of oral therapy was 26 days (range 14–42). Mean total duration of therapy was 41 days (range 28-56). The final oral antibiotic regimens used included linezolid in 19 patients (65%), amoxicillin in 5 patients (17%), co-trimoxazole in 3 patients (10%) and amoxicillin with rifampicin in 2 patients (7%). Change of oral agent due to adverse drug effects was required in 6 patients, all occurring in patients prescribed linezolid. Adverse outcomes occurred in three patients (embolic events in two patients and one death 4 months after treatment completion due to cardiac failure), with 5 patients yet to complete the full 6 month follow-up period.ConclusionsOral antimicrobial therapy can be used in appropriate patients with infective endocarditis, with good efficacy and relatively low rates of adverse effects despite significant complexity of illness. Alteration of oral regimen was frequently required when linezolid was used.

academic.oup.com

Kai Kupferschmidt@kakape.bsky.social · 8mo ago

And there it is: FDA has approved zoliflodacin for gonorrhea as well. That makes two new antibiotics to treat this STI and it means a fascinating debate now about how to use these drugs in a way that will delay resistance as much as possible… 🧪 #IDsky

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Zoonoses Journal@zoonoses-journal.org · 9mo ago

Toscana Virus (TOSV) Meningitis in Two Travelers in Southeastern Spain. Click the link below to read this #open_access article. #one_health #zoonoses #IDSky #Medsky www.scienceopen.com/hosted-docum...

Toscana Virus (TOSV) Meningitis in Two Travelers in Southeastern Spain

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d5571999e135">Two Irish tourists, a 72-year-old male and his 60-year-old wife, developed symptoms of m...

scienceopen.com

Paul Sax@paulsaxmd.bsky.social · 9mo ago

Tested two different AI products with some medical advice. Prompt: "When people get shingles again, is it usually in the same location?" OpenEvidence: Home run. ChatGPT: Big whiff. Plus, a chance to support the shingles vaccine -- so important! #IDSky blogs.jwatch.org/hiv-id-obser...

When AI Gets the Medical Advice Wrong — and Right

A journalist recently reached out to ask about the shingles vaccine. We mostly talked through the usual topics — how common shingles is, why the vaccine works so well, and side effects. Plus, the whol...

blogs.jwatch.org