N95health Samara

@samara-bsky.bsky.social

Native Habitat Geek #CovidisAirborne #N95 Meditating on climate change, science fact/ fiction, broken news, bird flu and cats, plus tips on surviving the zombie apocalypse

It's stiking how my grandparents generation collected scrap metal and put their lives on hold for years to solve the Nazi Axis crisis, but the world now can't bother to Work From Home, or not drive their gas car to save reserves, in a world facing an energy crisis. www.cbc.ca/news/politic...

Carney says the world is facing an 'energy crisis' and Canada must help solve it | CBC News

In B.C. to meet with the province's premier who is sceptical of another oil pipeline, Prime Minister Mark Carney said the world is in the throes of an "energy crisis" and Canada must do its part to su...

cbc.ca

🧬 New study: #COVID-19 HIJACKING of the Host EpiGENOME: Mechanisms, Biomarkers and Long-Term Consequences www.mdpi.com/1422-0067/26... #N95 to prevent #DNA damage. #SamaraSARS #Samara

COVID-19 Hijacking of the Host Epigenome: Mechanisms, Biomarkers and Long-Term Consequences

The epigenetics of COVID-19 is a rapidly expanding field that reveals how the SARS-CoV-2 virus initiates alterations in the host’s genome, influencing the susceptibility to infection, the disease severity, and long-term consequences, known as “long COVID.” In this review, we describe the mechanisms utilized by the virus to manipulate the host epigenome, suppressing antiviral responses and creating a favorable environment for viral replication. We also highlight virus-induced epigenetic changes across diverse cell populations that contribute to COVID-19 pathogenesis. Notably, the virus reprograms hematopoietic stem and progenitor cells, leading to long-lasting alterations in innate immunity, a phenomenon known as “trained immunity.” These epigenetic modifications are maintained in differentiated daughter cells and may explain the persistent inflammation and other symptoms of long COVID. Furthermore, we discuss emerging epigenetic biomarkers of disease severity, including methylation signatures in genes such as AIM2, HLA-C, and PARP9, as well as dysregulated miRNA profiles. Understanding this complex interplay between the virus and the host’s epigenetic landscape is crucial for developing new therapeutic approaches that target specific epigenetic modifications to suppress pathological processes and improve clinical outcomes for COVID-19 patients.

mdpi.com

Brain scans show #COVID can alter children’s development. Areas tied to language and listening sometimes improve with time. But changes in memory, emotions, and focus persist. Families say reinfections can wipe out recovery. Prevention matters. Kids must be included in research and care.

Brain Microstructural Alterations in Children Post‐COVID‐19 Infection Through VBM, SBM, and Structural Covariance Network Analysis

Background Children represent a particularly vulnerable group to the long-term consequences of COVID-19 due to their ongoing neurodevelopment. This study aimed to identify transient and persistent s...

onlinelibrary.wiley.com