In two back-to-back studies published in Genes & Development, a team led by Anindya Bagchi, PhD, uncovered a new framework for understanding how the PVT1 region regulates MYC activity. sbpdiscovery.org/press/resear... @anindyabagchi.bsky.social

A study from the Tharp lab and collaborators in #ScienceAdvances finds that nearby conditions and nutrients influence how cancer cells evade the immune system and reveals a potential way to stop this protection. sbpdiscovery.org/press/stripp...

Stripping away what conceals cancer cells from our immune system - Sanford Burnham Prebys

Study from the Tharp lab finds nearby conditions and nutrients govern how cancer cells avoid immune cells, and how to stop this protection.

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New research from the Boutros lab, published in BMJ Oncology, found that protein levels differ in lung tumors from men and women. Lung cancer also showed more sex-related protein differences than any other cancer type studied. sbpdiscovery.org/press/biolog... @chenghaozhu.bsky.social

Biological sex linked to protein changes in lung adenocarcinoma and other cancers - Sanford Burnham Prebys

Study shows lung adenocarcinoma has strong sex-based proteome differences, while five other cancer types have moderate differences.

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With Alzheimer’s, tau proteins form noxious knots and gradually disrupt the brain circuits they would otherwise preserve. The Huang lab showed in #ScienceAdvances that a different protein called SORLA offers protection against the effects of these lethal loops. sbpdiscovery.org/press/protec...

Sanford Burnham Prebys mourns the loss of T. Denny Sanford, whose visionary philanthropy helped shape our Institute and advance biomedical research. sbpdiscovery.org/t-denny-sanf...

T. Denny Sanford (1935-2026) - Sanford Burnham Prebys

Renowned philanthropist and businessman T. Denny Sanford passed away July 18, 2026 in his hometown of Sioux Falls, South Dakota. He was 90 years old.

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We’re excited to welcome Jill Mesirov, PhD, to Sanford Burnham Prebys as Distinguished Professor and Senior Vice President for Computational Science. sbpdiscovery.org/press/pionee...

Why does #prostatecancer in some patients grow slowly and remain localized while it becomes aggressive and metastasizes in others? In a new paper led by 🇺🇸 @sbpdiscovery.bsky.social, researchers identify the answer: #tumor methylation.

Kevin Tharp, PhD, was awarded a 3 year, $450,000 Ovarian Cancer Research Alliance grant. Tharp will use the new funding to follow up on research findings regarding how high grade serous ovarian cancer circumvents the immune system’s anti-tumor defenses. sbpdiscovery.org/kevin-tharp-...

Kevin Tharp awarded $450,000 Ovarian Cancer Research Alliance grant to break down tumor defenses - Sanford Burnham Prebys

The new award will fund research regarding how to bust through the barrier between tumors and immune cells.

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What can we learn from people who live past 100 in good health? Researchers from the U.S. and Europe gathered at Sanford Burnham Prebys to share new findings from the CIAO Study, an ongoing effort to uncover the secrets of healthy aging and longevity. 🧬🌿 sbpdiscovery.org/press/ciao-s...

CIAO Study: 11th annual longevity symposium provides new peeks and possibilities at  longer, healthier lives - Sanford Burnham Prebys

The Cilento Initiative on Aging Outcomes (CIAO) held its 11th annual research symposium at Sanford Burnham Prebys, with more than a dozen scientists and physicians from Europe and the US presenting ne...

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🎓 Congratulations to the newest graduates of the Sanford Burnham Prebys Graduate School of Biomedical Sciences! We're proud to welcome these talented scientists to our alumni community and look forward to celebrating their achievements in the years ahead. sbpdiscovery.org/sanford-burn...

Sanford Burnham Prebys recognizes 10 doctoral degree recipients - Sanford Burnham Prebys

The Institute’s Graduate School of Biomedical Sciences held its third Commencement ceremony to celebrate new alumni.

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Launching 50 for 50: 50 discoveries from 50 years at Sanford Burnham Prebys. Some transformed fields. Some opened doors others walked through. All worth knowing. More stories coming. sbpdiscovery50.org/50-for-50/

Cholesterol-craving cancers need lipid enzymes to use metabolites for growth |Study finds kinases move cholesterol in the cell to where it can activate a growth pathway in many aggressive cancers. The @bemerling.bsky.social Emerling lab published in #ScienceAdvances. sbpdiscovery.org/press/choles...

The Freeze lab and an international team of collaborators discovered a new rare genetic disease that interferes with brain development. They published findings in @hggadvances.bsky.social that identify the faulty mutated gene and show how it interferes with normal cellular function. bit.ly/4vul3h3

Researchers identify new genetic disease that interferes with brain development - Sanford Burnham Prebys

Study from the Freeze lab finds that a mutation destabilizes proteins involved in how children grow and mature.

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Nearly 40% of U.S. adults have metabolic syndrome, a condition that can lead to liver damage and fibrosis. A new study from Sanford Burnham Prebys highlights LARP6, an RNA-binding protein that helps drive fibrosis and may be a promising therapeutic target. sbpdiscovery.org/press/living...

Thank you to The San Diego Union-Tribune for helping share the story of Sanford Burnham Prebys as we mark 50 years of discovery and impact. We’re grateful for the spotlight on the people, science and community that have shaped our Institute since 1976. www.sandiegouniontribune.com/2026/02/27/a...

‘A novel approach’: Sanford Burnham Prebys celebrates 50 years of medical exploration

The La Jolla-based research institute continues its founding principle of collaboration across multiple fields

sandiegouniontribune.com

An international team including the Kaufman lab published in Nature.com showing that liver cell stress can both drive cancer and make tumors less resistant to immunotherapy. The findings may help physicians identify which patients are most likely to benefit from existing treatments.

Today, on International Day of #WomenAndGirlsInScience, we gathered for the latest Women in Science Lecture Series. Thank you for the thoughtful and engaging conversation Cheryl Anderson, PhD, MPH, MS and Angela Liou, MD. Grateful to everyone who joined us. #InternationalDayOfWomenAndGirlsInScience

Sanford Burnham Prebys scientists published in @cp-cellreports.bsky.social showcasing a new approach for measuring the activity of enzymes linked to cell death and a more complicated picture where protein activation cannot always be presumed by protein production. sbpdiscovery.org/press/metall...

Join us on February 11 for the next event in the Women in Science Lecture Series at Sanford Burnham Prebys, featuring a lecture and fireside chat that highlight the groundbreaking work and perspectives of women leaders in biomedical science. Must RSVP to attend: lnkd.in/gzkXQRrm

Advancing Together: 50 Years of Sanford Burnham Prebys - For 50 years, bold ideas, dedicated scientists, and a shared commitment to discovery have shaped who we are today. Join us as we celebrate this milestone year and look ahead to the next 50. youtu.be/Q4hNMzBq7N0?...

In this episode of the Epigenetics Podcast, we talked with Will Wang from @sbpdiscovery.bsky.social about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. #podcast #epigenetics Listen here: activemotif.com/podcasts-wil...

New research from Sanju Sinha, PhD, introduces DeepTarget, a tool that predicts both primary and secondary targets of cancer drugs. It could help repurpose existing medicines for more patients. sbpdiscovery.org/press/comput...

Meet Rouven Arnold, PhD, a postdoc in Peter Adams’ lab at Sanford Burnham Prebys. He studies how aging changes our cells—with the goal of preventing diseases like heart disease, cancer, and dementia. Learn what drives his work and his path into science. ➡️ https://bit.ly/47PtecX

Q & A with Postdoctoral Researcher Rouven Arnold, PhD, from the Adams Lab - Sanford Burnham Prebys

Meet one of our early-career scientists: Rouven Arnold, PhD

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Scientists at Sanford Burnham Prebys, the University of Minnesota and Duke University report in Nature that “biased modulators” can target GPCRs more precisely—expanding potential drug targets and reducing side effects. www.nature.com/articles/s41...

“Once we find the players that drive disease, we can find drugs to help,” says Sanjeev Ranade, PhD. New study reveals a key protein linked to heart defects in Down syndrome. 🧬❤️ sbpdiscovery.org/press/huntin...

🧬 Biomedical Sciences PhD Applications Now Open! Do you want to explore the science behind human health and disease? Our program is looking for curious and driven researchers ready to tackle the most pressing questions in biology and medicine. sbpdiscovery.org/education/gr...

We’re pleased to announce that Paul Boutros, PhD, MBA, has been named the new director of the National Cancer Institute (NCI) designated cancer center at Sanford Burnham Prebys Medical Discovery Institute. Read all about it! sbpdiscovery.org/press/paul-b...

👏 Congratulations to Xueqin Sherine Sun, PhD, on receiving a $600,000 grant from the V Foundation for Cancer Research to study glioblastoma, one of the most common and deadly brain cancers. sbpdiscovery.org/xueqin-sun-a...

What connects survival, science + diabetes care? Adam Heller, PhD. At 92, this Holocaust survivor, scientist + engineer shares how his innovations changed how millions manage diabetes. 🎙️Hear his remarkable story in Episode 5 of the podcast. 👀On YouTube: youtu.be/TEhPlF29yl4?...

Today, 62 National Cancer Institute (NCI)–Designated Cancer Centers issued a joint statement underscoring the importance of HPV vaccination. #HPVvaccine #HPVvax #EndHPVCancers