Newly published work from Ghaffari Lab in Cell Stem Cell introduces a lysosome-based strategy that reverses aging in blood-forming stem cells. They show that slowing lysosomal degradation is central to reducing inflammation and restoring regenerative capacity. authors.elsevier.com/a/1m9kd6tu0C...

In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field. www.biorxiv.org/content/10.1...

The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila

Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligat...

biorxiv.org

Two exciting preprints from @mlodziklab.bsky.social lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization. www.biorxiv.org/content/10.1...

A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling

Wingless (Wg)/Wnt signaling is critical throughout development and tissue homeostasis and associated with many disease states. Canonical Wg/Wnt-signaling is mediated by β-catenin (Arm in Drosophila ) ...

biorxiv.org

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