Congrats Angelika. Well deserved!

Angelika Feldmann@angelikafeldmann.bsky.social · 3mo ago

Honored and grateful to be receiving this generous prize from the family of Hella Bühler and @uniheidelberg.bsky.social. Big thanks to my lab and colleagues @dkfz.bsky.social, esp. to our directly involved collaborators: @niopeklab.bsky.social, @banitolab.bsky.social, and Frank Westermann.

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9

Congrats Francesca !

FMI science@fmiscience.bsky.social · 11mo ago

This year’s Ed Fischer Prize goes to Francesca Masoni (@schubelerlab.bsky.social) for her PhD on chromatin organization—revealing how the ISWI chromatin remodeler subcomplex NURF positions nucleosomes to safeguard genomic boundaries & gene regulation. Read more at www.fmi.ch/news-events/...

Our Open Day for Novartis was a great success! 🎉 Many @novartis.bsky.social colleagues joined us today to explore our science, meet our researchers & enjoy food trucks. Huge thanks to all volunteers and everyone who stopped by — here’s to more connections and collaborations!

Iconic!

FMI science@fmiscience.bsky.social · 11mo ago

A little piece of our history has a new home! The iconic logo that graced the old FMI building on the Rosental campus is now in the lobby of our new home on the Novartis campus, just across the river in Basel. A symbol of our journey and memories 🫶🧬

I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel. We used ddPCA to map the genetic architecture of the entire human bZIP interaction network. www.biorxiv.org/content/10.1... Thanks to all our co-authors for the great collaboration!

The genetic architecture of the human bZIP family

Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...

biorxiv.org

We all look forward to the Batki lab at FMI !!!!

Julia Batki@juliabatki.bsky.social · 12mo ago

I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉 We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.

Excited to share our latest preprint. www.biorxiv.org/content/10.1.... Lead by Lukas, we investigated multiple ways of assessing a TF's sensitivity to chromatin based on genome-wide binding profiles. The developed methods allowed us to quantify chromatin sensitivity across tested TFs.

A novel deep learning-based framework reveals a continuum of chromatin sensitivities across transcription factors

The genome-wide binding of many transcription factors (TFs) depends not only on the presence of their recognition motifs, but also on the surrounding chromatin context. This raises the question of how...

biorxiv.org

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

What a night! The FMI year-end party had it all: an inspiring speech from our director, a delicious dinner buffet, a hilarious meme contest, and our traditional cake showdown. Here's to a fantastic 2025 ahead! 🥂🎉