RNA-binding proteins (RBPs) often bind numerous transcripts - but do they act through a network effect? Our new paper in @plosbiology.org shows that the highly conserved LIN28 RBP controls developmental timing in C. elegans larvae through only two targets. doi.org/10.1371/jour... 1/n

Just published in @plosbiology.org: researchers in @labgrosshans.bsky.social reveal how LIN28 keeps development on schedule in C. elegans through just two key targets. www.fmi.ch/news-events/...

A small molecular module helps time development

Animal development depends on precise biological timing. FMI scientists have now uncovered a mechanism that helps keep this process on schedule. Their work in the tiny worm <em>C. elegans</em> shows t...

fmi.ch

Looking forward to joining the Doctoral Insights Symposium on 10 September and introducing students to the FMI PhD Program, our research, and life in Basel’s vibrant biomedical ecosystem 🧬

Doctoral Insights Symposium@docinsightssymp.bsky.social · 2d ago

Biomedical research excellence in Basel — Novartis, Roche, and Europe's strongest biotech ecosystem next door. FMI science epigenetics, neurobiology, cell biology. Small institute, massive impact. Symposium Sept 10 → doctoralinsights.at #DocInsights #FMI #Basel

Congratulations to Sophie Schmid from the Luethi lab on being awarded a Boehringer Ingelheim Fonds PhD Fellowship, which supports outstanding junior scientists in pursuing ambitious basic biomedical research projects. Wishing her every success!

Today in @natneuro.nature.com, researchers led by @felsenberg.bsky.social report that memories can persist as silent traces, recoverable with the right reminder. But misleading cues can distort recall and create false memories—showing how remembering can rewrite the past. www.fmi.ch/news-events/...

Forgotten memories can leave silent traces in the brain

A forgotten memory is not always a vanished one. FMI neuroscientists investigating the fruit fly brain found that some memories become inaccessible while leaving a silent trace behind. The right remin...

fmi.ch

Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

doi.org

Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · last yr.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Thank you @natgenet.nature.com for this nice Research Briefing www.nature.com/articles/s41... on our recent paper reporting live-cell measurements of Sox2 promoter bursting kinetics when varying its genomic distance from the SCR enhancer 👉 www.nature.com/articles/s41...

The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

nature.com

📢 𝗖𝗲𝗠𝗠’𝘀 𝗣𝗿𝗲-𝗘𝗥𝗖 #𝗣𝗼𝘀𝘁𝗱𝗼𝗰𝗣𝗿𝗼𝗴𝗿𝗮𝗺 𝗶𝘀 𝗻𝗼𝘄 𝗼𝗽𝗲𝗻! 👉 Join top researchers pursuing innovative, translational biomedical research at #CeMM & our partners @meduniwien.ac.at , @stanna-ccri.bsky.social & @aithyra.bsky.social 🔎 Apply by 31 August 2026 ➡️ https://bit.ly/4f0Sa67

Congratulations to Anna Vasilevskaya on successfully defending her PhD last week! Her PhD work tackled a fundamental challenge in neuroscience: constraining the set of plausible algorithms that could underlie cortical function 🧠 Well done!

In @natcomms.nature.com, FMI scientists show that before Hydra regrows a head or foot, its cells first rebuild an internal map—working out both where they are and what stage of regeneration they’ve reached—which may help explain how tissues repair themselves after injury. www.fmi.ch/news-events/...

Hydra rebuilds the body by restoring its internal cellular map

Before Hydra can regrow a head or foot, its cells appear to rebuild the internal map that tells them where they are and what they should become next, FMI researchers report. The work suggests that cel...

fmi.ch

The ERC Work Programme 2027 has been adopted. Planning to apply for an ERC grant? The first call, Starting Grants, opens on 22 July. Find out more 👉 erc.europa.eu/news-events/...

New ERC Work Programme sets out 2027 funding opportunities

The European Commission has today adopted the European Research Council (ERC) Work Programme 2027, setting out the funding opportunities, grant budgets, competition timetable and application rules for...

erc.europa.eu

📢 We’re hiring a Research Technician for a collaborative project in cellular & molecular neuroscience. Investigate mRNA localization and translation in neurons—and changes in neurodevelopmental conditions—using imaging, genome engineering and cryo-EM. Apply by August 21: www.fmi.ch/education-ca...

A useful reminder for PhD applicants: start early, research groups carefully, and keep an eye on those fall deadlines. Join the Doctoral Insights Symposium on September 10 for more tips and to learn more about leading PhD programs across Europe, including the FMI PhD program. doctoralinsights.at

Doctoral Insights Symposium@docinsightssymp.bsky.social · 3w ago

📋 PhD application season is closer than you think. 1. Research groups — read their papers 2. Draft a specific motivation letter 3. Line up references 4. Check deadlines (Sept–Nov) Get tips at the symposium Sept 10 → doctoralinsights.at #DocInsights #PhDTips

The #WeAreEULIFE series highlights shared priorities across EU-LIFE—a consortium of leading European life science institutes, including the FMI. This month’s focus is #Training. Stay tuned for the FMI’s story 💡

EU-LIFE@eu-life.bsky.social · 3w ago

We are highlighting voices from EU-LIFE member institutes that embody the alliance's priorities. Today, we showcase #Training with Anthie Moysidou, Marie Skłodowska-Curie Postdoctoral Fellow at @mdc-berlin.bsky.social in #Berlin ➡️ www.linkedin.com/feed/update/... #WeAreEULIFE

Congratulations to Tommaso Caudullo on defending his PhD last month! His work explored how the zebrafish brain learns and updates representations of smells over different timescales—offering new clues about how brains turn sensory experience into memory 🎓🐟 @rainerfriedrichlab.bsky.social

📣 #OpenCall: Project Funding Researchers can determine the nature and topic of their research projects independently. Open to all disciplines. 📆 Submission deadline: 1 October 2026 ➡️ Read more: sohub.io/b6cm

Big conferences are impressive. But how often do you actually meet someone there? 🤔 The Epigenetics Meeting was created differently. We have a great line-up of speakers with exciting research topics, ample time for discussion, and very familiar setting. Join us now: events.ie-freiburg.mpg.de

📢 We’re hiring a Cloud Platform Engineer to drive FMI’s transition to a modern hybrid cloud architecture. Help build the infrastructure supporting 20 research groups, advanced technology platforms and large-scale biomedical data analysis. Apply by August 31 at www.fmi.ch/education-ca...

Now out in Cell @cellpress.bsky.social: Researchers in the @priscaliberali.bsky.social lab & collaborators at @istaresearch.bsky.social show how regenerating gut tissue turns small cellular differences into stable patterns, revealing a broader principle of tissue repair. www.fmi.ch/news-events/...

How the gut rebuilds order after injury

FMI researchers and their collaborators have shown how regenerating intestinal tissue turns small initial differences between cells into stable patterns. The findings reveal a general principle for ho...

fmi.ch

Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements. Two new studies from the @marcbuhler.bsky.social group, now published in @cp-molcell.bsky.social, show how cells keep these potentially disruptive sequences under control. www.fmi.ch/news-events/...

How cells keep genomic hitchhikers under control

Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements, many of which have lost their ability to copy themselves into new locations but can still cause pr...

fmi.ch

If you’re at the FENS Forum, consider to join our symposium: S28 – Flexible Memory Systems: Adaptive and Maladaptive Pathways! Today Hall D at 15:40! Kate Wassum, Mihaela Iordanova, Scott Waddell, and Jan Haaker. @fensorg.bsky.social #FENS2026 fens2026.abstractserver.com/program/#/de...

It’s out!! 🎉 My first PhD paper has been published in Cell 🤩 A huge thank you to amazing co-authors @cschwayer.bsky.social and @davidbrueckner.bsky.social , and to our fantastic mentors @priscaliberali.bsky.social and @ehannezo.bsky.social for their guidance and support throughout this journey!

Prisca Liberali@priscaliberali.bsky.social · last mo.

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Yesterday we welcomed Biomedical Sciences Bachelor’s students from @utrechtuniversity.bsky.social to the FMI. They joined an institute intro, a tour of the Turco lab, and research highlights from the Bühler group. They also chatted with our scientists about life in the lab. Thank you for visiting!

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

😎 Our lecture hall was pretty packed. Almost 100 researchers from the TriRhena region and beyond came together for the latest edition of the Gene Regulation Club at MPI-IE. Thanks to everyone involved: @igbmc.bsky.social @fmiscience.bsky.social, @cibss.bsky.social @biologyunifreiburg.bsky.social, …

In this Q&A, @sivaratnakar.bsky.social, a PhD student in @guillaumediss.bsky.social’s group and one of FMI’s PhD reps, reflects on his fascination with the molecular world, his work on protein interactions, and the role of creativity and community in science. www.fmi.ch/news-events/...

Siva Ratnakar Immadi: Proteins, poetry, and creative spaces

In this Q&A, Siva Ratnakar Immadi, a PhD student in the Diss group and one of FMI’s PhD representatives, reflects on his fascination with the molecular world, his work on protein interactions, and the...

fmi.ch

📣 EU-LIFE & stakeholders call on EU decision-makers to recognise #MSCA as a core research programme for #FP10. As negotiations on FP10 advance, our message is clear: The MSCA model works. Now it needs the ambition and budget to deliver at the scale Europe requires. 🔗 eu-life.eu/newsroom/pub...

We cooled down the city of Freiburg a bit (currently 23°C) to heat up for the upcoming TriRhena Gene Regulation Club at the MPI-IE. The ½ day symposium starts today at 2PM in the lecture hall – with scientists from @fmiscience.bsky.social, @igbmc.bsky.social & MPI. Looking forward to a 🆒 meeting.

Yesterday we were honored to welcome @novartis.bsky.social CEO Vas Narasimhan to FMI. He met with our director, toured several labs and joined researchers, group leaders & staff for an informal get-together. Thank you for your curiosity, thoughtful questions & interest in our science and community!