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Leon Schulte

@schultelab.bsky.social

Human immunology through the RNA lens. Focused on macrophages, lncRNAs & systems immunology. Professor for RNA- and infection-biology @unimarburg.bsky.social. Web: http://rna-lab.org/

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Helmholtz-Zentrum für Infektionsforschung (HZI)@helmholtzhzi.bsky.social · 2w ago

Die Studie, die in @pnas.org erschienen ist, ist das Ergebnis einer Kooperation von @westermannlab.bsky.social & @jorg-vogel-lab.bsky.social mit @schultelab.bsky.social @unimarburg.bsky.social und vielen weiteren Partnern. www.pnas.org/doi/10.1073/...

A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense | PNAS

Macrophages are essential for both, to clear pathogens and preserve tissue homeostasis, yet the molecular regulators of this equilibrium remain inc...

pnas.org

Leon Schulte@schultelab.bsky.social · 3w ago

Excited to share our PNAS paper with @jorg-vogel-lab.bsky.social and @westermannlab.bsky.social! We identify SAILR, a human-specific lncRNA that binds 14-3-3β to support macrophage viability—its loss during infection strengthens antimicrobial defense. #RNA www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

@versteegga.bsky.social · last yr.

Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA. Paper: academic.oup.com/nar/article/...

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA

Abstract. Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective immunological checkpoint blockade in cancer immun

academic.oup.com

Max Perutz Labs Vienna@maxperutzlabs.ac.at · last yr.

🆕 publication! Cells don’t just fight infection - they fine-tune their immune response. A new study from the Versteeg lab in @narjournal.bsky.social led by Adrian Söderholm uncovers how RNA processing of JAK2 helps regulate immune signals ➡️ tinyurl.com/2py27c8u @univie.ac.at @meduniwien.ac.at

Leon Schulte@schultelab.bsky.social · last yr.

How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications! 🔗 rdcu.be/em7aM #lncRNA #macrophage #immunology

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...

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