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Stefano Crespi

@screspi.bsky.social

Assistant Professor in Organic Photochemistry at Uppsala University Editor of the Journal of Molecular Structure

15 Posts1162 Follower361 Folgt
George Williams@gtwsuprachem.bsky.social · last mo.

Really pleased to see our work on using rotaxanes to tune photoswitching out now! Great work by my first PhD student Alex and the group, with some amazing computational insight by @screspi.bsky.social and the team! onlinelibrary.wiley.com/doi/10.1002/...

Mechanically Interlocked Indigo Photoswitches

By incorporating indigo photoswitches into the axle of a rotaxane, which features a hydrogen bonding macrocycle, we demonstrate improvement in activation wavelength, photostationary states and therma...

onlinelibrary.wiley.com

Stefano Crespi@screspi.bsky.social · 6mo ago

Check out our latest publication in @angewandtechemie.bsky.social where we show that the infamous V shape in the substituent effects in the thermal isomerization of azobenzenes comes from a single nonadiabatic mechanism 🔥 and not a mix of two. onlinelibrary.wiley.com/doi/10.1002/...

The Nonadiabatic Nature of the Substituent Effects in Azobenzene

Unified nonadiabatic switching: thermal Z→E isomerization of para-substituted azobenzenes proceeds through a single nonadiabatic rotational pathway. The iconic bell-shaped Hammett plot is a σp artifa...

onlinelibrary.wiley.com

Tanja Weil@weilgroup.bsky.social · last yr.

We developed an AND-gated chemiluminescent photosensitizer that only generates light inside tumor cells, activating under 2 cancer cell-specific conditions. Many thanks to Wenwu Peng @pengww.bsky.social from Seah Ling Kuan's group @seahling.bsky.social & our collaborators! shorturl.at/uXTg3

Autonomous Activation of a Gated Chemiluminescent Photosensitizer Enables Targeted Photodynamic Therapy in Tumor Cells

Chemiluminescence-based photodynamic therapy (CLPDT) offers a promising solution to the light penetration limits of traditional PDT. However, it lacks spatiotemporal control. Intracellularly activated...

pubs.acs.org

Stefano Crespi@screspi.bsky.social · last yr.

Our pipeline to compute thermal barriers of photoswitches💡 is out!🥳 We especially focused on NBDs for MOST🔋 and imines, but also stilbenes and DAEs. Try it out! You need just chemdraws and freeware to get libraries computed doi.org/10.1002/cptc...

Semi‐Automated Pipeline for Transition State Search of Molecular Photoswitches

A semi-automated pipeline for the transition state search of molecular switches (PiTS3) is reported, which facilitates the search, optimization, and conformational analysis of transition states of ph...

doi.org

Fredrik Schaufelberger@fschaufelberger.bsky.social · last yr.

Over the moon that the first paper from Anja's studies on metal chelate rotaxanes is now online in @angewandtechemie.bsky.social. doi.org/10.1002/anie... Massive congratulations Anja, @daisypooler.bsky.social Huseyn, Monika and @screspi.bsky.social 🥳🎉🎊🍀🥃 Thread below --》

Modulation of Lanthanide Luminescence with the Mechanical Bond: Antenna‐Emitter Confinement in a Compact [2]Rotaxane

Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” ....

doi.org

Stefano Crespi@screspi.bsky.social · last yr.

Mati's work on aldehyde and COOH effect on HTIs is out! Nice collaboration with the Ott group for the inclusion and switching of HTIs in MOFs💡 doi.org/10.1002/chem...

The Effect of Aldehyde and Carboxylic Acid Substitution on the Isomerization of Hemithioindigo Photoswitches

Hemithioindigo (HTI) photoswitches exhibit robust photoisomerization under visible light and relatively high thermal bistability. In this work, we report various modifications of the HTI core, namely....

doi.org

KoenigChemistry@chemistrykoenig.bsky.social · 2y ago

Tert-butylamine as a labile ligand and base enables cross-coupling reactions with various nucleophile classes. A great collaboration of Jonas with the Sigman lab and Gschwind group #ChemSky #ChemCollabs #photocatalysis doi.org/10.1021/acsc...

Cross-Coupling Reactions with Nickel, Visible Light, and tert-Butylamine as a Bifunctional Additive

Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand desig...

doi.org

Orthaber Lab@orthaberlab.bsky.social · 2y ago

Absolutely delighted to see the light of this collaborative work between the @screspi.bsky.social team and our group, with all the spectroscopy help. Demonstrating degenerate isomerisation of phosphaalkenes using NMR spectroscopy #chemsky #NMRchat onlinelibrary.wiley.com/doi/10.1002/...

Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch

In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...

onlinelibrary.wiley.com

Stefano Crespi@screspi.bsky.social · 2y ago

Hey #Chemsky! For my first post, I am hyped to share our latest efforts on main group C=P photoswitches💡, where we explored their isomerization mechanisms and observed experimentally symmetric molecules switch via NMR!🧲🔍a great international collaboration! onlinelibrary.wiley.com/doi/10.1002/...

Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch

In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...

onlinelibrary.wiley.com

Harmit Singh Malik@harmitmalik.bsky.social · 2y ago

You ever have one of those amazing weeks when everything clicks in your multiple roles as an academic PI- scientist, mentor, parent, partner, colleague, psychologist, fundraiser, salesperson? (Yeah, me neither.) But screwing up each of these roles takes special talent. (I am that talented.)