Orientational self-sorting in small metal-organic cages. Work by @jcedemontmollin.bsky.social and co-workers, published #openaccess in Inorganic Chemistry: pubs.acs.org/inocaj/artic...

Our new paper in ACS Centr. Sci. is really special for us: We challenge our emerging mechanistic principles for catalysis with external electric fields under organic synthesis conditions with the holy grail in the field, and they pass, with distinction. pubs.acs.org/acscii/artic...

Thelepogine! Congratulations to Matt and Christoph on bringing this one home! I’m very fond of the final result. pubs.acs.org/doi/10.1021/...

Total Synthesis of the Diterpene Alkaloid Thelepogine through Enyne Hydroamination

The total synthesis of the atypical diterpene alkaloid thelepogine is reported. Our pathway features the asymmetric construction of a carbotricyclic intermediate that undergoes a 2,3-Wittig–Still rear...

pubs.acs.org

And we hast just published a vacancy for a Scientist Synthesis Automation at Roche in Basel, Switzerland: www.organic-chemistry.org/jobs/offers/... - Please check and share!

Drug companies have quietly stepped back from development programs in long COVID and related conditions, leaving patients with few options. cen.acs.org/pharmaceutic... #chemsky 🧪

Farewell and rest well to a phenomenal, inspiring, and prolific scientist. I will always remember a talk he gave at McGill that chronicled his scientific life story, ending with his advice on the secret to success: "You have to work very haaaard!" www.caltech.edu/about/news/c...

Caltech Mourns the Passing of Nobel Laureate Rudy Marcus (1923–2026)

Marcus passed away on July 16. He was 102.

caltech.edu

This strategy successfully overcomes the redox limitations of haloarenes and addresses two long-standing challenges in alkene difunctionalization. Great collaboration! #ChemSky #photocatalysis #sustainability

Communications Chemistry@commschem.nature.com · 4w ago

Just out: Photocatalytic halogen atom transfer enables general dicarbofunctionalization of alkenes with organic halides and CO2

www.organic-chemistry.org/abstracts/li... Unactivated olefins are converted to alkyl azides with bench-stable NaN3 in the presence of FeCl3·6H2O under blue-light irradiation.

"Strained ring preprint hat trick" at @lcsolab.bsky.social with the last work of Carlo Baldassari with IBM/NCCR Catalysis on the aminoarylation of cyclopropanes using complementary photo- and copper-catalyzed approaches now available at @chemrxiv.org doi.org/10.26434/che...

TRIPLE Triplet Triplet EnT catalysis in one pot —wondering how??😃 Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products. www.nature.com/articles/s41...

Triple energy transfer-enabled dearomative cycloaddition/rearrangement cascade of bicyclic azaarenes to structurally complex products - Nature Catalysis

Energy transfer (EnT) catalysed dearomative cycloadditions of bicyclic azaarenes are largely limited to [4+2] pathways, with higher-order cycloadditions being difficult to achieve. Now, the authors ci...

nature.com

Happy to share my cover for this article from @lcsolab.bsky.social! It highlights a new electrophilic entry into bicyclobutane chemistry, with sulfur and carbon nucleophiles giving access to fresh BCB space! Full text on @chemrxiv.org #sciart ⌬ #research ⌬ #chemistry

Functionalized N-heterocyclic diazoolefins. Work by Bastiaan Kooij with support from Sebastian Lange (synthesis), Rosario Scopelliti (XRD) & Farzaneh Fadaei-Tirani (XRD). Out in @daltontrans.rsc.org : doi.org/10.1039/d6dt...

Our work on NAHA-enabled carbonyl removal of cyclic ketones is now published in @jacs.acspublications.org ! Congratulations to Zining! pubs.acs.org/doi/10.1021/...

A convergent access to medium-size rigidified nitrogen heterocycles: Have a look at the last work of Stefano Nicolai and Daphne Lucidarme on the annulation of bicyclobutanes and azadienes to give azabicyclooctanes now as a preprint at @ChemRxiv chemrxiv.org/doi/full/10....

www.organic-chemistry.org/abstracts/li... A visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids enables the construction of 5-CF3-1,3,4-oxadiazoles.

Photochemical Synthesis of Pyrroles from Furans and Amines Submitting Authors: Jaehyun You, Donghyeon Kim, and Yoonsu Park Checking Authors: Eleonore Tacke, Bjarne T. Schulz and Nuno Maulide www.orgsyn.org/demo.aspx?pr...

This is the most excellent summary of Palladium catalysis … If you love AI graphics that are completely, irretrievably, absolutely WRONG #ChemSky #ChemChat (Thank you LinkedIn)

Stephadiamine, take two. A second synthesis is justifiable if you (a) radically change the strategy and (b) develop new methodology along the way. Congratulations, Ana Vi, on bringing this one home! pubs.acs.org/doi/10.1021/...

Concise Synthesis of (±)-Stephadiamine via Vinylogous Wenker Cyclization

A short and diastereoselective synthesis of stephadiamine is presented. The carbocyclic framework of the alkaloid was built in the opening step through a homoconjugate addition–Wittig olefination cascade with a modified Schweizer–Fuchs cyclopropyl phosphonium salt. The challenging aza[4.3.3]propellane was subsequently installed through a vinylogous substitution of an allylic hydroxy group with a primary amine that was developed for the purposes of the synthesis. After a series of oxidations, a second α-tertiary amine was introduced through a diastereoselective Strecker reaction, thus establishing the syn-diamine motif. Finally, an undesired retro-Strecker pathway was circumvented by using an azide functionality to mask the primary amine during a late-stage lactonization, thus enabling the completion of the synthesis in 12 steps.

pubs.acs.org

Happy to share our latest work, now published in Nature! Ligand-enabled remote C–H activation converts abundant saturated fatty acids into desaturated lactones. rdcu.be/fqn7c lnkd.in/dCYs2CMR Thanks to @NandanNilekani Foundation, @ANRFIndia @iitbombay @dm_lab

New preprint from #Kineticolor Computer Vision Enables Spatiotemporal Monitoring of UV-promoted Polyurethane Foam Degradation Kinetics Read it here: chemrxiv.org/doi/full/10....

Check out our recent work on @angewandtechemie.bsky.social ! We developed a transition-metal-free “cut-and-sew” reaction that formally inserts five-membered heteroarynes into benzocyclobutenones, providing access to fused heteropolycycles. Congrats to Cole! onlinelibrary.wiley.com/doi/10.1002/...

Transition Metal‐Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones

A transition metal-free insertion of five-membered heteroarenes into the C─C bonds of benzocyclobutenones has been achieved under mild and operationally simple conditions. This method provides an eff...

onlinelibrary.wiley.com

Excited to share another milestone in @angewandtechemie.bsky.social ! 🎉 We developed a mild, selective visible-light Birch-type reduction of 2-pyridones via EnT catalysis & sequential HAT, backed by computational insights. Huge thanks to the team! 🙌 onlinelibrary.wiley.com/doi/10.1002/...

Energy‐Transfer Catalysis Enables the Birch‐Type Reduction of 2‐Pyridones

In this study, a mild and selective visible-light-mediated Birch-type reduction of 2-pyridones has been developed. This protocol proved to tolerate a vast number of functional groups, which was achie...

onlinelibrary.wiley.com

Very happy to share the latest installment in our cycloaddition journey! Using steric and orbital control we are able to access highly substituted BCHs stereoselectively and with different substituents on each carbon bridges. Thanks and congratulations to the team!! pubs.acs.org/doi/10.1021/...

Stereoselective Photocatalytic Crossed [2 + 2] Cycloadditions to Enantioenriched Polysubstituted Bicyclo[2.1.1]hexanes

Bicyclo[2.1.1]hexanes are highly sought-after as rigid sp3-rich building blocks for medicinal chemistry with their twelve substituent positions providing exciting opportunities for molecular design. H...

pubs.acs.org

Very happy to introduce BCB-Bx as an electrophilic bicyclobutane synthon! Have a look at the preprint at @chemrxiv.org chemrxiv.org/doi/full/10....

Excited to share our new work in JACS! 📚 We use energy transfer activation of furans & oxazoles to generate distinct 1,4-biradicals. These undergo (5+4) cycloaddition with VCPs for rapid synthesis of heterobicyclo[5.2.1]decane scaffolds. Paper: pubs.acs.org/doi/10.1021/... #Photocatalysis #Chemistry

Accessing Medium-Sized Bridged Heterocycles via EnT-Catalyzed Intermolecular Dearomative (5 + 4) Cycloaddition of Furans and Oxazoles

Medium-sized bridged heterocycles are highly attractive structural motifs in bioactive natural products and medicinal chemistry. However, their broader exploration remains limited due to the lack of concise and modular synthetic strategies, as their synthesis is challenged by unfavorable enthalpic and entropic constraints. Herein, we report an energy transfer (EnT)-catalyzed intermolecular (5 + 4) dearomative cycloaddition of furans with vinyl cyclopropanes, providing direct access to (Z)-10-oxabicyclo[5.2.1]deca-3,8-diene scaffolds in a single step. Visible light triplet sensitization unlocks a distinct diene-type 1,4-biradical activation mode in furans. This triplet-state reactivity enables intermolecular higher-order (5 + 4) cycloadditions that remain inaccessible under conventional thermal activation. Mechanistic investigations support an energy transfer pathway and provide insights into the origin of the observed regioselectivity. The resulting partially unsaturated cycloadducts offer multiple synthetic handles for downstream functionalization, enabling rapid and modular incorporation of heterobicyclo[5.2.1]alkane motifs and highlighting their potential as versatile building blocks in synthetic chemistry.

pubs.acs.org

I did a thing: chicagomaroon.com/52978/viewpo...

#PhD position available in our group! 🙏 Share, recommend or apply! :-) For more info and to apply, follow this link: jobs.uzh.ch/job-vacancie... @chem.uzh.ch @juriceklab.bsky.social @snsf.ch #OpenPosition #PhDPosition #ApplyNow #JobOffer #JuricekLab

🥳Check out our latest paper "Assigning the stereochemistry of natural products by machine learning" by @markusorsi.bsky.social and Jean-Louis Reymond in Journal of Cheminformatics! 👉Read the full story: link.springer.com/article/10.1...

📢 We're hiring! 3-year postdoc in ultrafast spectroscopy via #MSCA network LEAPS-ULTRAFAST — a joint position between SwissFEL/PSI & my lab @EPFL. Propose your own project using large-scale light sources & table-top systems. Apply by Sep 30, 2026 👇 www.leaps-ultrafast.eu/e310921/e312...

www.organic-chemistry.org/abstracts/li... An iron-catalyzed alkylazidation of dehydroamino acids using peroxides as alkyl radical precursors