How to make a 4-cell square ascidian embryo? Cytoplasmic pulling rotates centrosomes, cortical forces lock the plane. Corentin Mollier & Shivani Dharmadhikari highlight a #preprint from Silvia Caballero-Mancebo & team @rdumollard.bsky.social #preLight ⬇️ prelights.biologists.com/highlights/c...

Cooperation between cortical and cytoplasmic forces shapes planar 4-cell stage embryos - preLights

How to make a 4-cell square ascidian embryo? Cytoplasmic pulling rotates centrosomes, cortical forces lock the plane.

prelights.biologists.com

One the most lovely combinations of science and art I have been to in a long time at Musée d’Orsay☺️✨ by the @manuelthery.bsky.social #cytomorpholab

#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.

A fun way to recover embryos on a grey Parisian day 🌧️🐭

Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵

I'll kick off my bsky profile with a great 3D fluorescence microscopy time-lapse. My buddies Joe Brzostowski and Rachel Stadler (NIH) acquired this on their #snoutscope that I helped them build. Shown is a fluorescent actin marker in Dictyostelium. Joe and Rachel called this "The Mark of Zorro!"

MBL scientists use skates and their embryos to study skeletal development. By shining a light through egg cases, scientists can watch the entire maturation process. Learn more about skates as a research organism here: bit.ly/3Rmvq3F 📹 Bioquest

The one and only Manu @prakashlab.bsky.social inspiring @mblscience.bsky.social Physiology students at this morning's lecture.

A great morning with the @mblscience.bsky.social Physiology students after my talk today.

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter

Is there a pattern of how they arrange in the drop or have I been staring through the microscope for far toooo long? 🧐😁#beautifulembryos

If you're in Europe you can watch it in French here: www.arte.tv/fr/videos/11...

Les succès volés - Rosalind Franklin et la découverte de l’ADN - Regarder le documentaire complet | ARTE

D’une ampleur comparable à la théorie de la relativité d’Einstein, la mise au jour de la structure en double hélice de l’ADN vaut en 1962 le Nobel de médecine au généticien James Watson, au biologiste...

arte.tv

Matthew Cobb@matthewcobb.bsky.social · 2y ago

Really nice ARTE programme about Rosalind Franklin and DNA featuring myself, Patricia Fara and a host of others. Some terrific light-hearted reconstructions (in particular Joan Bruce, the Time journalist). Commentary in German with English subtitles, but most interviewees speak English.

New cell line = New cell morphologies to explore! This hepatic cell line has fully invested into membrane protrusions! Actin is shown in 🟦 and DNA in 🟧 #FluorescenceFriday #SciArt

A woman studies embryos for decades, struggles for funding and respect. She publishes under her husband’s name, until they divorce. A single mother, she moves across an ocean to continue her studies. It all sounds quite modern, until you learn that she also worried she’d be burned as a witch. 🧵 1/15

Lovely work on shape evolution! Check out the story below:)

As a biologist, we have to often choose colors and the way of representation of data..but Pierre-Joseph Redouté’s plant illustrations are amazing and Nicholas Rougeux's collation and post processing and representation of data is beautiful! Lots of amazing stuff! check here - www.c82.net/work/

Interesting topic and a lovely lab to work in! Don’t miss out on the opportunity!

Nicolas Minc@minclab.bsky.social · 2y ago

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development. Details below 👇👇 Please Repost !!! @ijmonod.bsky.social @cnrs.bsky.social

Such an important way of progressing in any scientific question, yet so undervalued!

There is the beast of the year! Little hunting 🐙 And the beauty by Manon’s lovely heart! Its nice to be a part of the yearly tradition! 🎄

Jean Léon Maître@maitrejl.bsky.social · 2y ago

We end the year with our now traditional Beauty and the Beast contest: @sdharmadhikari.bsky.social octopus and Manon's ❤️ for the win! That's a wrap for 2024, which was particularly productive for the lab! Have a great holiday!

Yes! everybody has their favorite early Metchnikoff paper (before he moved on to such secondary pursuits as discovering innate immunity). Mine: his early intuition that animals evolved from colonies of flagellates that could transdifferentiate into amoebae - 100y before molecular phylogenies!

Cnidarian developmental mechanisms group@clytia-vlfr.bsky.social · 2y ago

That was another nice find -thanks John. We love Metchnikoff too -especially for his substantial contribution to invertebrate embryology, including of course this !

Check this riddle out!!☺️

The Company of Biologists@biologists.bsky.social · 2y ago

This is a human embryo at 4 cell-stage, with one of the cells in mitosis. This image is from this Behind the paper story about a medical doctor stepping into a #DevBio lab @maitrejl.bsky.social to study human embryo mechanics: thenode.biologists.com/when-a-medic... #ACloserLook

An interesting read! An article from John Hopfield on how he chooses to work on the next question(now what?)… a question, as a scientist we often ask ourselves! pni.princeton.edu/people/john-...

Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4 www.biorxiv.org/content/10.1...

A toolkit for testing membrane localisation tags across species

Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...

biorxiv.org

Congrats to double Doctor Julie Firmin on receiving the prize for her Great Advances in Biology from the Academie des Sciences!

Early mouse morula! Almost two years ago, I imaged my very first mouse embryo and since then I haven’t gotten over the funny apical domains (cyan)😍 nostalgic :) This beauty was part of the first immunostaining, I did when I joined the lab! #fluoroscentfriday

First snow of the year!! For someone who was used to 30 degrees all year along, snowing is special❄️🌨️ I will try to work today😉

Hatching blastocyst! When you fix the embryos wayyyy later than you wanted to, because you got caught up;) still a beautiful one though 😉☺️

Ovulation filmed from start to finish for the first time Approximately 400 times in a woman's life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh,... weiterlesen

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

Fun movie of the cell surface of mouse morula. Jiggly protrusions, now the task of quantifying them💪 Any suggestions!?