📢 Postdoctoral Researcher Position funded by ANRS-MIE A postdoctoral opportunity is currently open within the Plague and Yersinia pestis team, led by Dr Florent Sebbane. Please feel free to share this opportunity with your networks! @anrs-mie.bsky.social @inserm.fr @pasteurlille.bsky.social

Check out our new preprint deciphering SlyB structural role for membrane homeostasis during Yersinia pestis infection ! 👇🏻

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2mo ago

Yersinia pestis lipoprotein SlyB promotes plague pathogenesis via envelope stress tolerance https://www.biorxiv.org/content/10.64898/2026.06.08.730324v1

#CNRSLeJournal 📜 | Sébastien Bontemps-Gallo, bactériologiste au @ciilofficiel.bsky.social, étudie des tiques de l’espèce "Ixodes ricinus", celle qui nous pique le plus, pour aider au diagnostic de la maladie de Lyme 🪲 ➡️ lejournal.cnrs.fr/articles/tiq...

CNRS@cnrs.fr · 4mo ago


Les tiques, qui reviennent avec le printemps, peuvent transmettre aux humains la maladie de Lyme, très grave, mais aussi d’autres affections. Pour mieux les comprendre et améliorer les traitements, les chercheurs disposent désormais d’une « tiquothèque » de 80 000 spécimens.

📢 A new pub in @plos.org Pathogens by A. Dewitte, F. Sebbane and S. Bontemps-Gallo “Plasma albumin contributes to early Y. pestis survival at the onset of flea infection" @cnrs-hautsdefrance.bsky.social @cnrsbiologie.bsky.social @inserm.fr @pasteurlille.bsky.social @rechercheulille.bsky.social

Plasma albumin contributes to early Yersinia pestis survival at the onset of flea infection

Author summary Plague is caused by the bacterium Yersinia pestis and transmitted between mammals by fleas. To spread, the bacteria must survive in the flea gut after a blood meal. This environment is ...

dx.plos.org

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

shorturl.at

Né il y a plus de 130 ans, l’Institut Pasteur de Lille met la science au service de la santé. Aujourd’hui, nous faisons évoluer notre identité pour mieux refléter notre engagement collectif. 🎬 Découvrez notre nouveau film qui raconte qui nous sommes et où nous allons. youtu.be/UyxvGUHWWtk?...

Notre identité, notre héritage, notre avenir !

YouTube video by Pasteur Lille

youtu.be

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

Multiple protein structure alignment at scale with FoldMason

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

science.org

Our new website is now live! A redesigned interface to better showcase our research, teams, and latest news. ➡️ www.ciil.fr @cnrs-hautsdefrance.bsky.social @inserm.fr @cnrs.fr @pasteurlille.bsky.social @rechercheulille.bsky.social

#BonneAnnée 🌟 Le #CNRS vous présente ses meilleurs vœux pour l'année 2026 ! #HappyNewYear 🌟 The French National Centre for Scientific Research (CNRS) wishes you the very best for 2026!

A fascinating Review in Nature Reviews Microbiology shows how ancient pathogen genomics reshapes our understanding of infectious diseases. For Yersinia pestis, it synthesizes decades of work on plague evolution, while highlighting key open questions ahead. #microsky

Insights into infectious diseases through ancient pathogen genomics - Nature Reviews Microbiology

In this Review, Kocher, Krause and Spyrou explore how ancient pathogen genomics is providing new perspectives on the history and evolution of infectious agents. They show how ancient DNA has revealed ...

nature.com

Pourquoi certaines bactéries résistent-elles aux antibiotiques ? 🦠💊 Sébastien Bontemps-Gallo, bactériologiste au CNRS, tente d'y répondre.

Brève de science : pourquoi certaines bactéries résistent-elles aux antibiotiques ?

cnrs.fr

🦠 "Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte", un article de @sebbontempsgallo.bsky.social (@cnrs-hautsdefrance.bsky.social / @univlille.bsky.social) pour @france.theconversation.com 👇 theconversation.com/maladie-de-l...

Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

theconversation.com

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team “Selective accumulation of nanoparticles in infected cells for targeted drug delivery” @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

Selective accumulation of nanoparticles in infected cells for targeted drug delivery

In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

sciencedirect.com

#Recherche Issus du décryptage de la méthode de camouflage très efficace de la bactérie responsable de la maladie de #Lyme, 2 projets de #vaccins permettent de l’attaquer avant qu’elle ne puisse recourir à ce stratagème. Par @sebbontempsgallo.bsky.social de @cnrs.fr

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

buff.ly

Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales @cnrs-hautsdefrance.bsky.social @univlille.bsky.social

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

doi.org

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y) 🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project! 🔬 Profile: PhD in microbiology #Postdoc #Microbiology #YersiniaPestis #ResearchJobs

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y) 🔬 Profile: PhD in microbiology #Postdoc #Microbiology #YersiniaPestis #ResearchJobs

The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings. @rolandelliagus.bsky.social

First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia

🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity. @cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social

⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point. @pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social

Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France

[Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...

sante.ouest-france.fr

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...

dlvr.it

Just out in Nature Genetics @natureportfolio.nature.com ! Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.

Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics

Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...

nature.com

New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach. By @ugsf-lille.bsky.social @ciilofficiel.bsky.social @univlille.bsky.social @cnrs-hautsdefrance.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…

sciencedirect.com

[Resources] #AlphaFold protein and PPI prediction databases 1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org 2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr... 3️⃣ Human interactome prodata.swmed.edu/humanPPI 4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev 1/2

Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...

Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

nature.com

Michael Deghelt @michaeldeghelt.bsky.social · last yr.

#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...

#Climate extremes may reduce #Lymedisease risk? Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming. #VectorBiology

Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi

Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.

science.org

We will soon hire a postdoctoral fellow. Please contact me for more details.

Centre d'Infection et d'Immunité de Lille@ciilofficiel.bsky.social · last yr.

A project coordinated by Mathieu Gissot @gissotlab.bsky.social in collaboration with David Dauvillée @chlamyd0.bsky.social - @ugsf-lille.bsky.social , PSBToxo, has been selected by the #ANR More info below👇 @cnrs-hautsdefrance.bsky.social @univlille.bsky.social @pasteurlille.bsky.social @inserm.fr

#VSS Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale. Les travaux avancent ! Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026 @socialistesan.bsky.social @socialistes-senat.bsky.social

You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠 Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social 👉 Paper here! www.nature.com/articles/s41... #BacterialPredation #Bdellovibrio #StructuralBiology

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

nature.com