Duilio Silva
@selfishdna.bsky.social
Postdoc fellow at NIH. Genetics/Cell Biology/Selfish DNA.
Proper organelle regulation during mitosis is a must, but how do membrane-less condensates like PML bodies behave during cell division? In work led by Eric Aird, we found the balance of speckled proteins SP110 & SP100 to be the key. doi.org/10.1038/s415...
We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻🔬👨🔬🧬Looking forward to your application!✉️
I’m happy to announce that our preprint is out! 🧬🐭 We show that the mouse HSR selfish DNA kills embryos that do not inherit it through a toxin–antidote system, thereby increasing its transmission to the next generation. ⚡ Feedback is welcome! @takashiakeralab.bsky.social #SelfishDNA #meiosis4eva
biorxiv.org
📣Huge congrats to our postdoc, Takaya Totsuka, on his new paper @currentbiology.bsky.social 🎉 He found that Ca2+ oscillations regulate oocyte spindle rotation! 🐭The project started during his PhD with Prof. Miho Ohsugi. Free link: authors.elsevier.com/c/1lUqk3QW8S...
authors.elsevier.com
🚨Our latest work on selfish centromeres is published @currentbiology.bsky.social 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to our lab manager, Zaak Walton, who led the project🎉 Free link: authors.elsevier.com/a/1lQzN3QW8S...
authors.elsevier.com
Nice work from @takashiakeralab.bsky.social: Spindle checkpoint can secure additional cheating time for selfish expanded centromeres: Current Biology www.cell.com/current-biol...
Spindle checkpoint can secure additional cheating time for selfish expanded centromeres
Expanded centromere DNA repeats violate Mendel’s law of segregation by preferentially segregating to the egg in animals and plants. Using oocytes collected from hybrid mice, Walton et al. show that th...
cell.com
New Akera's lab paper! Congrats @takashiakeralab.bsky.social and Eddie!
Meiosis-specific distal cohesion site decoupled from the kinetochore - Nature Communications
In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled from the kinetochore in Perom...
nature.com
Proud of the first Brazilian movie to win an Oscar! "I am still here".
Camarote da República@camarotedacpi.bsky.social · last yr.O BRASIL CONQUISTA SEU PRIMEIRO OSCAR AINDA ESTOU AQUI VENCE COMO MELHOR FILME INTERNACIONAL É NOSSO, É NOSSOOOOOOOOOOOOOOO
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
biorxiv.org
For the ones facing hard times: "Giving up... I've thought seriously about it, but I've never really taken myself seriously; there's more ground in my view than tiredness in my legs, more hope in my steps than sadness on my shoulders, more road in my heart than fear in my head." Geraldo E. de Souza
Happy new year everyone! We are please to announce the return of MAYosis in 2025! Every Wednesday in May at 4pm CET, come hear the latest #meiosis4ever stories! Abstract sub deadline: March 8 (end of day wherever you are) meiosis.cornell.edu/mayosis2025/
MAYosis 2025
meiosis.cornell.edu
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
NIH funding is why the U.S. has a biomedical industry. The research at universities is crucial for new drug development. Doing this research as students is how we train researchers who go on to work in the private sector. Also funding medical schools is pretty important for training new doctors.
Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬
Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome Biology
Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...
link.springer.com
New paper out! Investigation on blind cavefish 🐟 chromosome evolution 🧬. Huge effort from pandemic time coming out. I almost got locked down away from home meeting with the co-authors 🤣 journals.plos.org/plosone/arti...
Investigation of Astyanax mexicanus (Characiformes, Characidae) chromosome 1 structure reveals unmapped sequences and suggests conserved evolution
Natural selection in the cave habitat has resulted in unique phenotypic traits (including pigmentation loss and ocular degeneration) in the Mexican tetra Astyanax mexicanus, considered a model species...
journals.plos.org
Amazing paper on B chromosomes! www.nature.com/articles/s41...
The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly - Nature Communications
Drive mechanisms in B chromosome systems remain unclear. Here, the authors assemble the rye B chromosome pseudomolecule, identify candidate trans-acting, drive-controlling factors of the B chromosomal...
nature.com
Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
Last Friday I had a great opportunity to show my work on mouse HSR chromosome biased transmission based on embryonic lethality at Mid-Atlantic Meiosis Mini symposium at NIH!
For all colleagues who still do not know much about B chromosomes, I would like to share this paper on the meiotic self-pairing of tetra fish Bs. pmc.ncbi.nlm.nih.gov/articles/PMC... As well as these ones: bmcbiol.biomedcentral.com/articles/10.... pubmed.ncbi.nlm.nih.gov/36077895/
I am very happy to share our recent publication 𝑹𝒆𝒑𝒆𝒂𝒕-𝒃𝒂𝒔𝒆𝒅 𝒉𝒐𝒍𝒐𝒄𝒆𝒏𝒕𝒓𝒐𝒎𝒆𝒓𝒆𝒔 𝒐𝒇 𝒕𝒉𝒆 𝒘𝒐𝒐𝒅𝒓𝒖𝒔𝒉 𝑳𝒖𝒛𝒖𝒍𝒂 𝒔𝒚𝒍𝒗𝒂𝒕𝒊𝒄𝒂 𝒓𝒆𝒗𝒆𝒂𝒍 𝒊𝒏𝒔𝒊𝒈𝒉𝒕𝒔 𝒊𝒏𝒕𝒐 𝒕𝒉𝒆 𝒆𝒗𝒐𝒍𝒖𝒕𝒊𝒐𝒏𝒂𝒓𝒚 𝒕𝒓𝒂𝒏𝒔𝒊𝒕𝒊𝒐𝒏 𝒕𝒐 𝒉𝒐𝒍𝒐𝒄𝒆𝒏𝒕𝒓𝒊𝒄𝒊𝒕𝒚 in Nature Communications @natureportfolio.bsky.social rdcu.be/dZk7W
Repeat-based holocentromeres of the woodrush Luzula sylvatica reveal insights into the evolutionary transition to holocentricity
Nature Communications - Unlike most eukaryotes, Luzula sylvatica assembles holocentromeres along the entire chromosome length. Here, the authors combine genome assembly, epigenetic and cytogenetic...
rdcu.be
