Tessera

Raquel Fueyo @fueyoraquel.bsky.social · 11mo ago

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

Shady Saad @shadys11.bsky.social · 11mo ago

I’m very excited to share that Stanford Medicine has highlighted my work med.stanford.edu/news/insight...

Behind the Science: How a ‘speech gene’ could help treat Huntington’s

Stanford Medicine researchers found cells that keep a speech-linked protein called FOXP2 from clumping; its tricks could break apart clumps of proteins that cause devastating brain diseases.

med.stanford.edu

Ryan Flynn @raflynn5.bsky.social · last yr.

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...

Cedric Boeckx @cedricboeckx.bsky.social · last yr.

What did the two amino acid substitutions in #FOXP2 that occurred uniquely in the human lineage do? 🧪🧬 🧠 Fascinating new @cp-cell.bsky.social study by @shadys11.bsky.social D. Jarosz & J. Wysocka, uncovering a molecular function for these 2 substitutions in promoting the solubility of FOXP2. (1/n)

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

cell.com

Simon Fisher @profsimonfisher.bsky.social · last yr.

When we first isolated FOXP2 & implicated it in speech disorder, a notable feature was its big stretch of consecutive glutamine (Q) residues, the longest polyQ tract in a native protein. @shadys11.bsky.social et al here use it as a model to reveal how polyQ proteins avoid forming toxic assemblies.🙌🧪

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

cell.com

Shady Saad @shadys11.bsky.social · last yr.

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social www.cell.com/cell/fulltex...

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

cell.com

Cell - a Cell Press journal @cp-cell.bsky.social · last yr.

Now online! DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-promoting mechanisms utilized by FOXP2 diminishes aggregation and amyloid formation by the pathological form of Huntingtin polyQ.

dlvr.it