1/8 SGLT2 inhibitors are a cornerstone of HF prevention, but do they work in patients with a genetic predisposition to cardiomyopathy? Out in @NatureMedicine, our latest from the @TIMI_Study_Group evaluates dapagliflozin in carriers of rare CMP variants.

Dr. James Pirruccello identified new genetic factors that help explain why some people develop aortic stenosis by analyzing advanced heart imaging and genetic data from 60,000 healthy participants from the UK Biobank. www.nature.com/articles/s41...

Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk - Nature Genetics

Genome-wide association studies (GWAS) of deep learning-derived measurements of aortic valve function, along with multitrait analyses incorporating disease-based GWAS, identify 166 genetic loci associ...

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We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis. nature.com/articles/s41... 1/10

Can a single ECG tell us who has coronary artery disease? I’m excited to share the publication of our paper on using electrocardiogram-based artificial intelligence to predict prevalent coronary artery disease in @jaccjournals.bsky.social Advances.

Im very honored to have been awarded with the Young Investigator Award "Arrhythmia" at the 91st annual meeting of the German Cardiac Society for our work on using clinical, genetic and AI risk for prediction of AF risk. Thanks for all co-authors and my mentors Shaan Khurshid and Patrick Ellinor.

Ever written an entire paper to fill out two empty cells in a table? Along with @shinokany.bsky.social and colleagues, we did just that: proposing cutoffs for mild aortic stenosis using mean gradient, peak velocity, and aortic valve area (AVA). Free article: authors.elsevier.com/a/1ks2B2d9GI...

Happy to share our study “New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals” in which we identify a new threshold for Mild AS and the consequences of early aortic valve dysfunction. @jamespirruccello.com authors.elsevier.com/a/1ks2B2d9GI...

I am excited to share our latest study published @jaccjournals.bsky.social Adv. We found that meeting guideline-recommended physical activity (PA) levels—whether as a “weekend warrior” or via regular activity—is linked to lower visceral and pericardial fat. www.sciencedirect.com/science/arti...

“Weekend Warrior” Physical Activity and Adipose Tissue Deposition

Attaining guideline-recommended levels of physical activity is associated with substantially lower risk of cardiometabolic diseases.Although physical …

sciencedirect.com