Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
Signal Transduction and Targeted Therapy (STTT) | A Nature Portfolio journal | Impact Factor 52.7 | Q1 in Biochemistry, Cell Biology & Molecular Medicine | Open Access Visit: https://www.nature.com/sigtrans/
MSC transplantation induces #Neutrophil aggregation and an EV storm through TNFα/ICAM-1/Rab11b, while neutrophil EVs rebalance Th17/Treg cells via DHA/LILRB4/STAT5/STAT3 to promote immune tolerance and #SLE remission. #STTT #OpenAccess: doi.org/10.1038/s413...
Researchers identify an ENO1–lactate–H4K12la feedback circuit that activates quiescent #BreastCancer stem-like cells (qsBCSCs) through PCNA transcription, while disrupting the axis suppresses qsBCSC activation and #TNBC growth. #STTT #OpenAccess: doi.org/10.1038/s413...
The clinical-stage anti-TFRC antibody PPMX-T003 suppresses #ColorectalCancer growth in a patient-derived #Xenograft and reduces liver metastatic seeding and colonization, supporting TFRC-targeted therapy for #Metastatic cancer. #OpenAccess: doi.org/10.1038/s413...
Single-cell #Multiomics shows that #TNBC-derived #Exosomes drive regulatory and dysfunctional T-cell states, suppress immune effector programs through miR-98-5p, and generate distinct tumor-specific γδ and αβ TCR clonotypes. @IUIndianapolis #STTT #OpenAccess: doi.org/10.1038/s413...
Learn how AI-guided models predict biallelic RB1 loss in #HepatocellularCarcinoma subtype with distinct vulnerabilities from routine slides, uncovering synergistic therapeutic responses to mitotic and DNA damage inhibitors. #STTT #OpenAccess: doi.org/10.1038/s413...
Can lasting #Antithrombotic protection be achieved without severe bleeding risks? This study shows that partial GPVI downregulation by low-affinity antibodies provides sustained protection against #Thrombosis while preserving hemostasis. @uni-wuerzburg.de #OpenAccess: doi.org/10.1038/s413...
Lactate drives #Cancer progression via metabolic, signaling & #Epigenetic mechanisms. Insights into how lactate and #Lactylation impact tumor immunity, #Metastasis & therapy resistance, while highlighting therapeutic strategies. #STTT #OpenAccess: doi.org/10.1038/s413...
Darlifarnib plus cabozantinib demonstrated encouraging safety and efficacy signals in patients with advanced renal cell carcinoma (RCC). 📊✨ Read more ➡️ www.onclive.com/view/darlifa... #KidneyCancer #RCC #GUonc #Cabozantinib #TargetedTherapy #PrecisionOncology #ClinicalTrials #Oncology #kcsm
Darlifarnib Plus Cabozantinib Displays Early Signals of Safety and Efficacy in RCC | OncLive
Adanma Ayanambakkam, MD, MS, discusses findings from the FIT-001 trial of darlifarnib plus cabozantinib in RCC.
onclive.com
An experimental synthetic #mRNAPlatform could help deliver next-generation #mRNATherapeutics—including #vaccines for #InfectiousDiseases, #cancer, and #AutoimmuneConditions—more quickly and efficiently than current industry standards.
Experimental synthetic mRNA platform could improve cancer and infectious disease treatments – BioNews Central
An experimental synthetic mRNA platform could help deliver next-generation mRNA therapeutics—including vaccines for infectious diseases, cancer, and autoimmune conditions—more quickly and efficiently than current industry standards. ...
sbee.link
📢Save the date: September 30th, 2026, 18:00 CET! Register for the new ENETS @enets.org webinar: “Liver transplantation in NET disease: Expert consensus and clinical updates”. ✅This free webinar is open to all HCPs - registration here: www.enets.org/upcoming-web... #LetsTalkAboutNETs
Translating #stemcellproducts into safe and effective therapies remains challenging. This review examines clinical progress and the challenges in manufacturing, quality control, safety, administration and long-term efficacy. #STTT #OpenAccess: doi.org/10.1038/s413... #RegenerativeMedicine
First-in-class #Oncology drugs are reshaping #CancerTherapy via novel targets, precision strategies & emerging modalities. This review maps global innovation and highlights challenges limiting their clinical translation. @tsinghuauniversity.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
Humoral immunity can either restrain or support #Cancer progression. This review explores how B cells, antibodies, plasma cells and tertiary lymphoid structures shape #TumorImmunity and therapeutic responses. @univlille.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
Cancer cells can exploit EMT to acquire invasive, metastatic and therapy-resistant traits. This review details the molecular drivers and cellular plasticity of #EMT and discusses therapeutic strategies targeting this program. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerTherapy
Limited first-line options challenge advanced #PDAC treatment. This phase Ib/II study found that surufatinib + camrelizumab + nab-paclitaxel/ S-1 improved response rate and progression-free survival vs nab-paclitaxel + gemcitabine. #STTT #OpenAccess: doi.org/10.1038/s413...
How does cellular metabolism directly influence viral #Pathogenesis? Research shows that #Lactylation of the #SARSCoV2 spike protein is essential for viral entry and infection, highlighting a unique target for novel #Antivirals. #STTT #OpenAccess: doi.org/10.1038/s413...
Targeted administration of a #SUMOylation inhibitor TAK-981 significantly enhances CD19 CAR-T cell therapy against #BurkittsLymphoma. This approach improves tumor eradication, offering a valuable strategy to optimize #Immunotherapy. #STTT #OpenAccess: doi.org/10.1038/s413...
Can we reverse cardiac aging? A longevity-linked BPIFB4 gene variant prevents diastolic dysfunction in #Progeria mice. This finding offers a promising #GeneTherapy strategy to combat #CardiovascularAging. @bristoluni.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
A seven-protein plasma panel distinguishes clear cell renal cell carcinoma from healthy controls while linking circulating biomarkers to TGF-β, VHL–HIF/#Hypoxia and NT5E signaling, advancing #Biomarker discovery. #ccRCC @umeauniversity #STTT #OpenAccess: doi.org/10.1038/s413...
Contribute to the evolution of patient-centered care by submitting your research to #GU27! Bring your latest innovations in GU cancer research to the leading symposium of its kind. Connect w global leaders & optimize pt outcomes. Abstracts due Oct 13: https://bit.ly/4giREzB @astro-org.bsky.social
New findings? Bring them to #ASHG26. Submit a late-breaking abstract with research that advances discovery, deepens understanding of genetic mechanisms, and informs clinical care. Selected abstracts may be presented as an oral talk or poster. 🔗 https://bit.ly/3PKPMpZ #ASHG
Neeta Somaiah, MD, discusses the significance of the Peak study and what an approval of bezuclastinib plus sunitinib would mean for GIST. @mdanderson.bsky.social #oncology www.onclive.com/view/peak-se...
Peak Sets the Stage for Bezuclastinib/Sunitinib to Move Into the Advanced GIST Treatment Paradigm | OncLive
Neeta Somaiah, MD, discusses the significance of the Peak study and what an approval of bezuclastinib plus sunitinib would mean for GIST.
onclive.com
MEF2D-fusion BCP-ALL lacks definitive targeted therapies. This study identifies the CABIN1-derived peptide CB15 as a direct MEF2D-fusion inhibitor that suppresses #Oncogenic transcription and induces #Leukemia cell death. #STTT #OpenAccess: doi.org/10.1038/s413...
Defective macrophage #Efferocytosis can sustain #Autoimmune #Inflammation. This study shows that inhibiting SIKs, particularly SIK3, enhances #Efferocytosis through p300–PPARγ signaling and alleviates #Arthritis pathology. @SeoulNatlUni #STTT #OpenAccess: doi.org/10.1038/s413...
AAV transduction can trigger #Nephrotoxicity independently of genome editing. Using #KidneyOrganoids, this study links AAV-induced #Genotoxicity and inflammation to canonical NF-κB activation, #Fibrosis and tubular #Senescence. @harvardmed.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...
#PDAC remains resistant to many therapies because #Oncogenic signaling and an #Immunosuppressive microenvironment reinforce tumor progression. This review examines molecular targets, #Biomarkers, and emerging combination strategies. @ucsandiego.bsky.social #OpenAccess: doi.org/10.1038/s413...
Cardiovascular #Ageing involves interconnected molecular, cellular, and systemic changes that increase disease risk. This review examines these 12 hallmarks, signaling pathways, and emerging therapeutic strategies. #STTT #OpenAccess: doi.org/10.1038/s413... #Geroscience | #MolecularMedicine
#ERstress can protect cells during transient stress but drive pathology when persistent. This review examines IRE1, ATF6, and PERK signaling across major diseases and evaluates therapeutic strategies targeting the UPR. #STTT #OpenAccess: doi.org/10.1038/s413...
Why does #EsophagealCancer remain so challenging to treat? This review connects molecular pathogenesis, tumor evolution, early detection, and risk stratification with emerging targeted and immune-based therapies for precision care. #STTT #OpenAccess: doi.org/10.1038/s413...
Overcoming #immunesuppression requires targeting the #TumorMicroenvironment itself. This review explores immune modulatory #Vaccines against IDO, PD-L1, ARG1, and TGF-β and their potential to complement checkpoint blockade. #STTT #OpenAccess: doi.org/10.1038/s413...
