Bro resurrected NASA simulator in a weekend with Claude Code and used data from the real space launches to find the parameters to run it, and turns out it still works really damn well.

@bes-dev.bsky.social · 3mo ago

How was your weekend? I spent mine launching the Space Shuttle. With NASA code from 1970 that nobody could run for 50 years.

Yours truly is a proper scientist now! TL;DR: we used AI to redesign parts of essential cell machinery with only 19 canonical amino acids instead of 20. Why? Great thread by @harriswang.bsky.social provides more context and details. Let me talk a bit about the AI design part of this. 1/

Harris Wang@harriswang.bsky.social · 3mo ago

1/ Excited to share our new paper in Science @science.org: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” A great collab w/ Sergey's group @sokrypton.org at MIT @columbiasysbio.bsky.social science.org/doi/10.1126/... 🦠🧬🛠️🖥️💥

Great to have our manuscript with @sokrypton.org 's lab describing AfCyDesign finally out in @natcomms.bsky.social . Structure prediction, sequence redesign, de novo hallucination of cyclic peptides, and some binder design examples in this version. rdcu.be/em0vA

Cyclic peptide structure prediction and design using AlphaFold2

Nature Communications - AfCycDesign: Cyclic offset to the relative positional encoding in AlphaFold2 enables accurate structure prediction, sequence redesign, and de novo hallucination of cyclic...

rdcu.be

Oh wow great @haleaziz.bsky.social piece on a 2018 case in which Trump’s ICE screwed up and erroneously deported a guy. AND THEY BROUGHT HIM BACK because why wouldn’t they? We’re in a much darker place now. Free link: www.nytimes.com/2025/04/15/u...

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with @martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org 🧬 Code will be released in a couple weeks

BOOSTER, a newly identified orphan gene, supercharges photosynthesis and, when overexpressed, boosts height of poplars by up to 200% (at least in greenhouse) To make it even more interesting, part of the gene seems derived from a poplar fungus-farming ant 🐜 Paper: www.cell.com/developmenta...

Biology is amazing

Drew Berry wehi.tv@drewberry.bsky.social · 2y ago

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)

Fully accepting nothing may work out is a surprisingly effective way to work something out. Here’s the catch: knowing this fights against acceptance.

I would love for a social network to exist where questions like this get a meaningful discussion. I don’t think Twitter had it even if it’s best days, with a few exceptions when tweet randomly goes viral. Can we make it work here? That would take the whole community to a next level.

Akos Nyerges@akosnyerges.bsky.social · 2y ago

Friends, does anyone know the per-base error frequency of the new Illumina MiSeq i100 Series, with its 2 x 300 nt XLEAP-SBS chemistry? Is it better or worse than the old MiSeq v3 chip's error frequency (based on your sequencing runs)? #NGS #Illumina #MiSeq

Made a biotech founders starter pack, DM me to be added! go.bsky.app/LWm8uPE

Noticed that whenever I see a tweet I like, the first thing I do is check if author is on BlueSky. Glad to be here!