SimulaBetaTeam
@simulabetateam.bsky.social
Current news on #insulin-#glucose #homeostasis and the physiological simulation software #SimulaBeta Bochum, Ulm, London, Singapore https://simulabeta.sourceforge.io
Gestational #diabetes is a risk factor for diabetes mellitus in the newborn. A recent study found piglets born to hyperglycaemic mothers to have reduced #SPINA-GR, compensatorily increased #SPINA-GBeta and marginally reduced #SPINA-DI. doi.org/10.1007/s00125-026-06906-z
🧪 🩺 #MedSky @medsky.social #Endocrinology #Endosky
SimulAdrenTeam@simuladrenteam.bsky.social · 6mo ago#SimulAdren, the open dynamic simulator for the #HPA-axis, i. e. the #hypothalamus-pituitary-adrenal feedback control, has been released in version 2.0.1. This is a recommended update that fixes several bugs. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...
Wiley sent us a note that our paper defining the static disposition index #SPINA-DI is among the top-viewed articles of the Journal of Diabetes. pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753... www.livivo.de/doc/M38169110
![Abstract
Aims: The widely used dynamic disposition index, derived from oral glucose tolerance testing, is an integrative measure of the homeostatic performance of the insulin-glucose feedback control. Its collection is, however, time consuming and expensive. We, therefore, pursued the question if such a measure can be calculated at baseline/fasting conditions using plasma concentrations of insulin and glucose.
Methods: A new fasting-based disposition index (structure parameter inference approach-disposition index [SPINA-DI]) was calculated as the product of the reconstructed insulin receptor gain (SPINA-GR) times the secretory capacity of pancreatic beta cells (SPINA-GBeta). The novel index was evaluated in computer simulations and in three independent, multiethnic cohorts. The objectives were distribution in various populations, diagnostic performance, reliability and correlation to established physiological biomarkers of carbohydrate metabolism.
Results: Mathematical and in-silico analysis demonstrated SPINA-DI to mirror the hyperbolic relationship between insulin sensitivity and beta-cell function and to represent an optimum of the homeostatic control. It significantly correlates to the oral glucose tolerance test based disposition index and other important physiological parameters. Furthermore, it revealed higher discriminatory power for the diagnosis of (pre)diabetes and superior retest reliability than other static and dynamic function tests of glucose homeostasis.
Conclusions: SPINA-DI is a novel simple reliable and inexpensive marker of insulin-glucose homeostasis suitable for screening purposes and a wider clinical application.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:yxkip4xxf4mlialvuuoisc2w/bafkreidjchyquyfdzhiisypyqhskslenupf3d7wgc7ffwaryfvjeibdysy)
Hier ein Beispiel für eine berühmte Simulation mit einem #Analogrechner: Das Modell der #Insulin-Glukose-Homöostase von Bolie (1960). Dieses Modell hatte einen enormen Einfluss auf unser Verständnis des #Diabetes mellitus und lässt sich mit modernen Analogrechnern jetzt wieder direkt reproduzieren.
#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...
Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy. pubmed.ncbi.nlm.nih.gov/41852474/ doi.org/10.3389/fend...
30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7. Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.
#Trndi is a #glucose monitoring application written in #Object_Pascal. It fetches interstitial sugar readings from continuous glucose monitors (CGM) via different APIs and shows them on the desktop. It also presents a trend over time, colouring, and JavaScript extensions. trndi.app
The theory underlying this advanced method was developed based on computer simulations written in #Object_Pascal. pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753... www.livivo.de/doc/M38169110 #Pascal #programming
Diagnosis of #diabetes mellitus and #prediabetes: A simple calculation may be better than a complex test. 🧪 🩺 #MedSky @medsky.social #Endosky #Endocrinology medicalxpress.com/news/2024-01...
New calculation offers simple and reliable early prediction of diabetes
Diabetes often remains undetected until it has already damaged organs or nerves. This is partly due to the fact that diagnosis at an early stage is time-consuming and difficult.
medicalxpress.com
#CyberUnits Bricks has been released in version 2.1.0. This version introduces a proportional-integral (PI) block, scaling for systems diagrams, a solver for algebraic equations, extended ASIA elements, additional demo programs, and bug fixes. cyberunits.sf.net doi.org/10.5281/zeno...
Metabolische Phänotypisierung durch mathematische Modellierung der #Insulin-Glukose-Homöostase Mathematische Modelle und Simulationen der Insulin-Glukose-Homöostase sind nützlich, da sie physiologische Erkenntnisse liefern und klinische Entscheidungen unterstützen. www.doccheck.com/de/detail/ar...
Previsione precoce semplice e affidabile del diabete blogpinali.wordpress.com/2024/01/23/p...
Previsione precoce semplice e affidabile del diabete.
Il diabete spesso rimane inosservato finché non ha già danneggiato organi o nervi. Ciò è in parte dovuto al fatto che la diagnosi in fase precoce è difficile e dispendiosa in termini di tempo. Un t…
blogpinali.wordpress.com
Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics
SPINA Carb 5.1.0 Cyclone has been released in its final version. #SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...
Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno... #SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA
Release candidate 2 of #SPINA_Carb is available for testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...
After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing. sourceforge.net/projects/spi... doi.org/10.5281/zeno... doi.org/10.5281/zeno...
#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin. pubmed.ncbi.nlm.nih.gov/40217596/
I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes. onlinelibrary.wiley.com/doi/toc/10.1... doi.org/10.1111/1753...
Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1. www.klinikum-bochum.de/fachbereiche...
The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality. doi.org/10.53201/LEI...
The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺 pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753...
Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++. 🧪🩺 doi.org/10.14201/adc... revistas.usal.es/cinco/index....
Die Deutsche Gesellschaft für #Kybernetik, Informations- und #Systemtheorie hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen. Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.
Gratulation an @drjwdietrich.bsky.social für den Heinz-von-Foerster Preis für Organisationskybernetik!
A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal. Today, this innovative approach is covered by all major press agencies and news channels all over the globe. news.rub.de/english/pres...
Simple and Reliable Early Prediction of Diabetes
A simple blood test could perform better than a complex test thanks to mathematical modeling.
news.rub.de
Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...
#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0. simulabeta.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...
