What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis

RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...

bit.ly

Delighted to see our recent work on the use of self-assembling nanoscale calibrants for detecting errors in #ExpansionMicroscopy, particularly in visualising the biology of small organelles such as endosomes, featured in C&EN. cen.acs.org/analytical-c...

Nanosize rulers help correct distortion in inflated cells

Nanosize rulers and computer analysis help fix uneven inflation of organelles

cen.acs.org

We are so proud to share that our very own Dr Sami Al-Izzi has been awarded an ARC DECRA for his groundbreaking work in applying maths & theoretical physics to unlocking secrets of devel & mechanobiology. Sami has been supported by @r-g-morris.bsky.social & @emblaustralia.org. Congratulations! 👏👏👏

MACSYS@macsys.bsky.social · 8mo ago

Congratulations to MACSYS Research Fellow Dr Sami Al-Izzi - just awarded an ARC Discovery Early Career Researcher Award (DECRA): macsys.org/sami-al-izzi... @r-g-morris.bsky.social

Come and work with us! 👇

Izzy Jayasinghe@ijayas.bsky.social · 10mo ago

📣 We are hiring! An education-focused Lecturer or Senior Lecturer in Quantitative Biomedical or Biophysical sciences. It’s a chance to be a part of a team of single molecule /cellular biophysicists building a brand new undergraduate curriculum, here at UNSW in sunny Sydney. Happy to answer queries.

Privileged to join the ranks of EMBL Australia’s partner laboratories steering committee, representing @singmolsci.bsky.social, the EMBL Aus node in Single Molecule Science. Lots of new developments around the corner for this wonderful Medical & Life Sciences community in Australia.

EMBL Australia@emblaustralia.org · 11mo ago

We’re expanding our Partner Laboratory Network Steering Committee! 🎉 Thrilled to welcome Lisa Butler, Edwina McGlinn, @ijayas.bsky.social, Amee George, @ryanlister.bsky.social & Denise Doolan to our #leadership team - strengthening national & international collab'n in life sciences. bit.ly/4gFxzDE

Well done to the team from Single Molecule Science who participated in the Science in the Swamp celebration of 2025 National Science Week at Centennial Park, Sydney. 'Microscopic Safari' was a fun journey over everything in the nano and micron scale on a sunny winter Sunday. ✨😎 🧪

Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data

Nature Communications - Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed...

rdcu.be

Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬

ARC Centre of Excellence in Synthetic Biology@arccoesb.bsky.social · last yr.

🚀 Meet Our Centre Startups: SWAN Genomics with Associate Professor Lawrence Lee SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology youtu.be/WCT3sA2-jtY?...

Hello #AcademicBsky hivemind! Is there anyone out here (preferably from Australia / nearby) who uses FIB or BE lithography at submicron resolution on materials like quartz, and might be interested in collaborating with us on a cool new project? Happy to take recommendations. 🧪 🔬

A beautifully elegant study from Vaish and Leeba and team looking at mitochondrial volume regulation using cleverly designed and fabricated chambers to track fission yeast divisions over time

Vaishnavi Ananthanarayanan (She/Her)@vaishananth.bsky.social · last yr.

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n) 📖 www.biorxiv.org/content/10.1...

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n) 📖 www.biorxiv.org/content/10.1...

Aaaand that’s a wrap at Asia Pacific Microscopy Congress 2025 in sunny Brisbane, attended by a big team from Single Molecule Science. Lots of exciting new 🔬 tools and translation in biomedical investigations. @ijayas.bsky.social @arindam92.bsky.social

We’ve had a single molecule festival here today at the @UNSW SciFest yesterday. Our corner of the exhibition featuring light sensing robots 🤖, reef cleaning super hero bacteria 🦸🏾‍♂️ , miniature microscopes, when killer T cells. A wonderful team effort and a busy evening for Team Molecular Medicine.

Final week for applications for up to 2 postdoc posts in advanced biomedical (super-resolution) microscopy with my team in Sydney, based at @singmolsci.bsky.social. The post is especially suited for ECRs interested in single molecule imaging, &/or image analysis. International applicants welcome 🧪

The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature. @singmolsci.bsky.social #UNSWSBMS 🔗 nature.com/articles/s41... 🎨: Jon Berengut

🚨preprint @biorxivpreprint.bsky.social We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023 🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52...

Molecular Machines & Structural Virology Group@molecmachines.bsky.social · 3y ago

🚨Join us at UNSW Sydney! We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠. #SingleMolecule #microscopy🔬 Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics

Being able to work with a research & cultural leader like Izzy @ijayas.bsky.social is an opportunity you won’t want to miss.

Izzy Jayasinghe@ijayas.bsky.social · 3y ago

If there is anybody on Bluesky with an interest in working towards a PhD with a vibrant and inclusive group of people, we have a funded project available through @singmolsci.bsky.social in UNSW, Sydney, to do some advanced single molecule & electron 🔬. Please pass on to any students you may know. 🧪

Thanks for highlighting our (@polybiotique.bsky.social) report and its coverage by @dyanilewis.bsky.social, Izzy. As we mention in our report, fixing this will require clearly earmarked resources, and importantly, the will and strong commitment to equity from the leadership in Indian academia.

Izzy Jayasinghe@ijayas.bsky.social · 3y ago

A shocking description 👇🏾 of how women are being let down by scientific research communities in India. This is of course only mirroring many of the trends that we know exist everywhere else too. The 📊 showing conferences where women are outnumbered or excluded entirely leaves one absolutely appalled.

Latest paper from our team on variations in cellular staining with 14 different fluorescent dye esters when combined with expansion microscopy. Strategic deployment of these dyes with expansion 🔬 can not only provide EM-like images, but also highlight different sets of cellular organelles. 🧪

Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion ...

Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for nondescript staining of cellular and tissue architectures. We characterised the staining patterns of 14 fluorescen...

pubs.rsc.org

A few things that I've needed to get off my chest for some time now. 🧪 🌋

Remembering the role of luck and privilege in academic achievement

This week I woke up to the announcement by my alma mater — The University of Auckland — of its 2023 cohort of ’40 under 40’ that listed me…

medium.com

Towards inclusive and sustainable scientific meetings

Felicity Davis@davislab.bsky.social · 3y ago

Our thoughts on how to make conferences more inclusive and sustainable - with @vaishananth.bsky.social and a great international team. Check it out here: rdcu.be/dqHEM

🚨Join us at UNSW Sydney! We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠. #SingleMolecule #microscopy🔬 Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics