Tomorrow is the deadline for AEpiA 2026 early bird registration and abstract submission! AEpiA 2026 will be held from 14–16 Sept 2026 at the National Wine Centre, Adelaide, bringing everyone together for 3 days of outstanding science, discussion and networking #AEpiA2026 #Epigenetics #Adelaide

AEpiA 2026 early bird registration open now! Calling all epigenetics researchers, let’s meet, share, and connect! 14–16 Sep | Adelaide 🇦🇺 | National Wine Centre Register: 2026aepia.com.au/registration Abstracts: 2026aepia.com.au/abstracts #AEpiA2026 #Epigenetics #Chromatin

Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Online now:

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize PRC2-mediated H3K27me3 deposition, limit Polycomb domain spreading, and enable timely activation of developmental genes in vivo.

dlvr.it

What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis

RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...

bit.ly

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...

Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery

DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...

biorxiv.org

🎉 𝙒𝙝𝙖𝙩 𝙖 𝙙𝙖𝙮! 🎉 On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong. #EMCR #AEpiA #epigenetics

Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase @haiboyu.bsky.social @lisannes.bsky.social @molecularhorizons.bsky.social www.nature.com/articles/s42...

Optimised nanobody-based quenchbodies for enhanced protein detection - Communications Biology

Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase and 2 nM sensitivity f...

nature.com

🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟 We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! aepia.org.au/emcr-symposium

A purpose built solution to Australia’s biomedical funding crisis….. release the #MRFF = invest in our future scientists & their discoveries. #DiscoveriesNeedDollars www.smh.com.au/politics/fed...

The Asia RNA Club Symposium will be happening in Seoul in Nov 3-5, bringing together RNA scientists from the Asia-Pacific region. Excellent speakers and a great opportunity to connect! Abstract submission by Sept 5 asiarnaclub.org

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology. medicine.yale.edu/systems-engi...

Research

The immune system is a spatially distributed, whole-body sensory-reactive system that monitors, reacts, and adapts to various stress signals (e.g., tissue

medicine.yale.edu

Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data

Nature Communications - Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed...

rdcu.be

Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬

ARC Centre of Excellence in Synthetic Biology@arccoesb.bsky.social · last yr.

🚀 Meet Our Centre Startups: SWAN Genomics with Associate Professor Lawrence Lee SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology youtu.be/WCT3sA2-jtY?...

Join our group (www.luginbuehllab.com) at @camplantsci.bsky.social! Are you excited about mycorrhiza, (single-cell) transcriptomics, carbon physiology, and the model crop rice? We have a 2-year postdoc position available, starting ASAP. Closing date 23rd May 2025! www.jobs.cam.ac.uk/job/51214/

We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!

Mechanism of quality control of gene expression revealed by @anatv.bsky.social & @scottbscience.bsky.social’s groups in study of Pol II molecules. Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi... #LMBResearch

Was a pleasure working with @anatv.bsky.social on this!

Ana Tufegdzic Vidakovic@anatv.bsky.social · 2y ago

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...

📣 New paper from the lab! In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew. www.cell.com/molecular-ce...

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.

cell.com

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

The PNUTS phosphatase complex controls transcription pause release

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...

cell.com