Check out our new paper applying fast DIA proteomics to bacterial co-cultures at scale. www.nature.com/articles/s41... @kiranrpatil.bsky.social

Interspecies interactions drive bacterial proteome reorganization and emergent metabolism - Nature Ecology & Evolution

An analysis of the responses of 15 diverse human gut bacteria in more than 100 pairwise co-cultures reveals extensive remodelling of the bacterial proteome and metabolome in response to the presence o...

nature.com

Our paper mapping the effects of hundreds of pesticides and industrial chemicals on gut bacteria is out in @natmicrobiol.nature.com today! Turns out many such chemicals, although labelled as 'fungicides' or similar, can inadvertently inhibit friendly gut bacteria. www.nature.com/articles/s41...

#NewResearch 🚨Out now! Human gut bacteria bioaccumulate forever chemicals, in intracellular aggregates and colonization of gnotobiotic mice with these bioaccumulating bacteria increases faecal PFAS excretion. @kiranrpatil.bsky.social #MicroSky #MicrobiomeSky 🦠 www.nature.com/articles/s41...

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

nature.com

Check out our new paper showing that xenobiotics like pesticides and drugs can disrupt metabolic homeostasis in gut bacteria.

MRC Toxicology Unit@mrc-tu.bsky.social · last yr.

Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism. Find out more here: buff.ly/5akzsgs @kiranrpatil.bsky.social @skamrad.bsky.social

Check out our new preprint! We systematically map proteomic and metabolomic interactions between >100 pairs of gut bacteria, detecting metabolic interactions and functionally-related clusters of proteins. www.biorxiv.org/content/10.1... @kiranrpatil.bsky.social

Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism

Species in microbial communities must respond to the presence of others to stave off resource competition or to capitalise on new resources that may become available due to additional metabolic activi...

biorxiv.org

Check out our latest work on the unexpected inhibitory effects of common agricultural and industrial chemicals on our gut bacteria. A great collaboration with Anna, Indra and Kiran et al at the MRC Tox Unit in Cambridge. www.biorxiv.org/content/10.1...

Off-purpose activity of industrial and agricultural chemicals against human gut bacteria

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

Super excited to join @meehubs.bsky.social over the next 3 days and hear about microbial ecology. Loving the concept of a hub conference so far!