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Stylianos Lefkopoulos (he/him)

@slefkopoulos.bsky.social

Senior Editor at @natcellbio.nature.com: #stemcells & #embryo development #disease | proud scientist | 🏳️‍🌈 gender fluid, antisexist, liberal | 🍫 📚 🐶 🧑‍🍳 🌱 |📍Berlin | views are his own | call him Stelios

227 Posts3252 Follower355 Folgt
Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · last wk.

🥂 Yao, Li, Gai et al. profile normal coronary artery, early and advanced coronary atherosclerosis human samples with scRNAseq: they identify a progenitor-like endothelial subtype with functional implications in disease progression. 👉 rdcu.be/fwFme #Academicsky www.nature.com/articles/s41...

Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression - Nature Cell Biology

Yao, Li, Gai et al. profile normal coronary artery and early and advanced coronary atherosclerosis samples from humans using single-cell transcriptomics and identify a progenitor-like endothelial subt...

nature.com

Nature Cell Biology@natcellbio.nature.com · last wk.

☕Liu, Huang, Shen, Shao, Jing et al. combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy. www.nature.com/articles/s41...

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

nature.com

Nature Cell Biology@natcellbio.nature.com · 2w ago

☕Bae et al. identify MED4 as a regulator of tumor dormancy from a genome-wide CRISPR screen, and show that loss of MED4 alters the enhancer landscape and induces extracellular matrix remodeling to drive metastatic relapse in breast cancer. 👉https://rdcu.be/fvKaZ www.nature.com/articles/s41...

Mediator subunit MED4 enforces metastatic dormancy in breast cancer - Nature Cell Biology

Bae et al. identify MED4 as a regulator of tumour dormancy from a genome-wide CRISPR screen, and show that loss of MED4 alters the enhancer landscape and induces extracellular matrix remodelling to dr...

nature.com

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · 2w ago

🥂In a recent study in our journal, the authors combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy. www.nature.com/articles/s41...

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

nature.com

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · 2w ago

☕Anyone here who still doesn't know this? In this month's @natcellbio.nature.com issue, we introduce a Collection on #stemcell embryo models. #devbio 👉Editorial here: rdcu.be/fu8UA Collection below: www.nature.com/collections/...

Stem cell-based embryo models

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

nature.com

VivienM@vivienm.bsky.social · 4w ago

So #ISSCR2026 is on and you can't go ...bummer! The next best thing to reading papers or doing laundry or cleaning the trunk instead is...the sneak peek podcast with the @isscr.org meeting co-chairs Fiona Doetsch and Nozumo Yachie. Sneak-peek of the sneak peek podcast share.transistor.fm/s/27284ba5

ISSCR annual meeting: sneak peek of the sneak peek podcast | Conversations with scientists | Episode 54

The annual meeting of the International Society for Stem Cell Research (ISSCR) is coming up July 8-11. If you are interested in stem cells, please tune into the sneak peek podcast of this meeting. And...

share.transistor.fm

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · 4w ago

👋On my way to the @isscr.org meeting in Montreal. Looking forward to meeting as many of you as possible! Feel free to message me ;) In the meantime, who hasn't read our Editorial on the #StemCell #embryo model collection we just announced at @natcellbio.nature.com ? #ISSCR2026 👉Here: rdcu.be/fsIeP

Learning from stem cell-based embryo models

Nature Cell Biology - Efforts to construct stem cell-based embryo models are thriving, with numerous potential implications for basic and translational research. We now introduce a Collection of...

rdcu.be

Nature Cell Biology@natcellbio.nature.com · last mo.

👋Attending the @isscr.org meeting in Montreal this week? Our #StemCell & development editor @slefkopoulos.bsky.social will be there and happy to chat - message him! #ISSCR2026 🍰In the meantime, take a look at our new Collection of stem cell-based #embryo model papers: www.nature.com/collections/...

Stem cell-based embryo models

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

nature.com

Nature Cell Biology@natcellbio.nature.com · last mo.

👋In this month's editorial, we introduce a Collection of articles in the area of #StemCell - based #embryo models. The collection will be updated as we publish new content. 👉Read here: rdcu.be/frN7h www.nature.com/articles/s41...

Learning from stem cell-based embryo models - Nature Cell Biology

Efforts to construct stem cell-based embryo models are thriving, with numerous potential implications for basic and translational research. We now introduce a Collection of articles that highlight rec...

nature.com

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · last mo.

Ok, who will be attending the @isscr.org meeting next week in Montreal? I ‘ll be around, so don’t hesitate to reach out to discuss your work for @natcellbio.nature.com or just meet in person and have a chat! :) #ISSCR2026 www.isscr2026.org

ISSCR 2026

An international gathering of the brightest minds in stem cell research and regenerative medicine across disciplines. Join us for the 2026 ISSCR Annual Meeting 8-11 July 2026 in Montréal, Canada.

isscr2026.org

Nature Cell Biology@natcellbio.nature.com · last mo.

☕He, Wang, Ding et al. report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25. 👉https://rdcu.be/fq3ms www.nature.com/articles/s41...

Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics - Nature Cell Biology

He, Wang, Ding and colleagues report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25.

nature.com

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · last mo.

🥂Single-cell transplantations of long-term #hematopoietic stem cells(HSCs), in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @natcellbio.nature.com www.nature.com/articles/s41...

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - Nature Cell Biology

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...

nature.com

Francesca Cesari@francesari.bsky.social · last mo.

A study published in Nature identifies an electrocardiogram marker by using an AI model trained on electrocardiograms of individuals that experienced sudden cardiac death. www.nature.com/articles/s41...

An ECG biomarker for sudden cardiac death discovered with deep learning - Nature

A deep-learning model trained on electrocardiogram (ECG) waveforms identifies an easily visible biomarker that predicts sudden cardiac death more accurately than the current clinical state of the art.

nature.com

Nature Cell Biology@natcellbio.nature.com · last mo.

☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social www.nature.com/articles/s41...

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - Nature Cell Biology

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...

nature.com

Nature Cell Biology@natcellbio.nature.com · last mo.

☕Wei et al. show that Meg3+ #hematopoietic stem cells (HSCs) expand upon #aging and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocyte/platelet and myeloid skewing in aged HSCs. www.nature.com/articles/s41...

Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing - Nature Cell Biology

Wei et al. show that Meg3+ haematopoietic stem cells (HSCs) expand upon ageing and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocy...

nature.com

Nature Cell Biology@natcellbio.nature.com · 2mo ago

☕This Review discusses the roles of #ferroptosis in shaping the immune landscape in glial #tumors and highlights potential strategies that combine ferroptosis induction with #immunotherapy for a durable control of gliomas. #CellDeath 👉https://rdcu.be/foVLA www.nature.com/articles/s41...

Emerging roles of ferroptosis in modulating the immune landscape of glial tumours - Nature Cell Biology

This Review discusses the roles of ferroptosis in shaping the immune landscape in glial tumours and highlights potential strategies that combine ferroptosis induction with immunotherapy for a durable ...

nature.com

Springer Nature@springernature.com · 2mo ago

Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, was born and raised in Indonesia but moved to Canada during high school. @natcellbio.nature.com spoke to him about his journey as an LGBTQIA+ immigrant: #PrideInSTEM 🌈

A scientist can come from anywhere

This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and academic journey as an LGBTQIA+ immigrant.

spklr.io

Nature Cell Biology@natcellbio.nature.com · 2mo ago

🏳️‍🌈This June, we celebrate Pride by discussing with @gunawanlab.bsky.social about his personal and academic journey as an LGBTQIA+ immigrant. Happy Pride month! #PrideinSTEM #LGBT 👉https://rdcu.be/forCt www.nature.com/articles/s41...

A scientist can come from anywhere - Nature Cell Biology

This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...

nature.com

Stylianos Lefkopoulos (he/him)@slefkopoulos.bsky.social · 2mo ago

🌈 At a time when progress can't be taken for granted, I 'm especially proud to share this @natcellbio.nature.com Q&A piece. I had the pleasure to discuss with @gunawanlab.bsky.social about his inspiring journey as an LGBTQIA+ immigrant. #PrideInSTEM 👉 rdcu.be/fnXQ6 www.nature.com/articles/s41...

A scientist can come from anywhere - Nature Cell Biology

This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...

nature.com