Sonya

@sonyahanson.bsky.social

Research Scientist at the Flatiron Institute | biological temperature sensors 🌡️ cryo-EM 🔬computational biophysics 👩🏼‍💻

Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

ROCKET came out on Nature Methods today. It takes a tremendous amount of effort to translate a research concept into a practical tool—one that researchers can seamlessly drop into their existing pipelines. We learned a lot along the path and will carry that spirit forward.

Alisia Fadini@alisiafadini.bsky.social · 4mo ago

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem

CAHRA 2025: Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms

A community-wide data processing challenge for cryo-electron microscopy.

heterogeneity.notion.site

From a Twitter research project to an independent rival — Bluesky’s journey under CEO Jay Graber shows how a decentralized, user-first platform gained millions users by prioritizing control & openness in social media. A true alternative in a billionaire-dominated space. www.cnbc.com/2025/08/29/b...

Bluesky CEO: I turned a Twitter research project into a rival company—'we've achieved what a lot of people said was impossible'

Under CEO Jay Graber, social media company Bluesky has grown to 38 million registered users while weathering large-scale challenges over the past few years.

cnbc.com

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

EMBL@embl.org · last yr.

Interested in research infrastructures career? The #ARISE2 Fellowship Programme might be right for you. MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪 🗓️ Call opening: 30 June www.embl.org/training/ari...

I was asked an interesting question at a (worky/networky) dinner this week. "What percentage of the human proteome has experimentally determined structures?" - Do you know the answer off the top of your head?

Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.

A small Montana town grapples with the fallouts from federal worker cuts

Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.

npr.org