New SPCG review paper on "component systems" from genomes and ecosystems to language, cities, and software. How do we separate universal combinatorial patterns from system-specific signatures? journals.plos.org/complexsyste...

New SPCG paper. With the Bokinsky lab (Milan Lacassin), Andrea Ripamonti modeled the competition for transcriptional resources. Our data and model jointly show how E. coli’s second messengers ppGpp & cAMP reshape gene expression globally. www.sciencedirect.com/science/arti...

Transcriptional competition biases the effects of second messengers in Escherichia coli

Cells regulate gene expression by balancing transcriptional resources across different functional groups of genes. In Escherichia coli, second messeng…

sciencedirect.com

New SPCG preprint in collaboration with the Amir lab We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations. arxiv.org/abs/2605.070...

Our Hands On Growth Laws Theory Cookbook is out today! journals.aps.org/prxlife/abst... It covers cell growth models through step-by-step recipes, bridging theory and practical applications, from basic to complex settings. Happy cooking! With @micalilab.bsky.social and @lciandrini.bsky.social

Saddened to learn of the passing of Moselio "Elio" Schaechter—Distinguished Professor at Tufts, SDSU and UCSD—humanist and visionary leader in the fields of microbiology and scientific communication—mentor, friend, and inspiration to me and so many others Small Things Considered Big Things Achieved

Our group has a SEMM PhD opening in single-cell dynamics and cancer persistence: www.semm.it/sites/defaul... We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome. Apply here www.semm.it/education/ap...

Our "Growth Laws Theory Cookbook" preprint is out! 👨‍🍳👩🏼‍🍳🧑‍🍳 arxiv.org/abs/2507.19194 *Learn our hands-on recipes and create your own!* With Ciandrini and Micali labs @micalilab.bsky.social Thanks to Rossana Droghetti for coordinating the heavy lift.

The Hands-On Growth Laws Theory Cookbook

This tutorial covers the emerging field of coarse-grained cellular growth modeling, and aims to bridge the gap between theoretical foundations and practical application. By adopting an original "cookb...

arxiv.org

Our work on optimal treatment in presence of cancer persisters is out today in @prxlife.bsky.social 🎉 Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters journals.aps.org/prxlife/abst...

Optimal Treatment for Drug-Induced Cancer Persisters Involves Release Periods and Intermediate Drug Doses

Extending persistence modeling to drug-induced, dose-dependent cancer persistence reveals that strategic drug holidays and reduced doses can improve long-term treatment outcomes.

journals.aps.org

🚨 We're hiring! 🚨 A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential. 🔗 More info here: docs.google.com/document/d/1... Please repost! #Postdoc #Genomics #Yeast #Polyploidy #Evolution

Postdoc_Evol_Genomics_Sorbonne.docx

Postdoctoral position in Yeast Evolutionary Genomics Hosting unit Laboratory of Computational, Quantitative, and Synthetic Biology (CQSB). The CQSB is an interdisciplinary research unit within the ...

docs.google.com

Excellent opportunity for Palestinian 🇵🇸 students looking to pursue Bachelor/Master degrees - 97 full scholarships across 37 Italian universities - Covers fees, housing, meals, health insurance - €12,000/year average scholarship Inquiry deadline is May 23 Links below, please circulate widely!

Great fun and great science at QMPE 2025 in Shenzhen! www.qmpe.net

Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density. Together, they restore dry mass density homeostasis. www.biorxiv.org/content/10.1...

Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast. tinyurl.com/4jmk3tkh

New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally. www.biorxiv.org/content/10.1...

New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws www.nature.com/articles/s41...

Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli - Nature Communications

Current theories of bacterial growth physiology often lack mechanistic detail. Here, Droghetti et al. present a theoretical framework that includes sensing and regulation of protein synthesis at the m...

nature.com

We just landed from X... almost ready to post about a lot of our recent news! See here for our old posts x.com/SPCGgroup