We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

The culmination of a fantastic collaboration between our lab and Bob Yauch’s lab that resulted in the uncovering of a proteosomal regulatory mechanism for PP2A. Congratulations to all the authors! www.nature.com/articles/s41...

Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation - Nature

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness

nature.com

Thrilled to share our new work on how the human RAD51 paralogs cooperate to build and stabilize RAD51 filaments, published today in Nature. www.nature.com/articles/s41... Congratulations to all authors!

How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! www.biorxiv.org/content/10.1...