ICYMI: New online! CRISPR–Cas-based live cell imaging of genome dynamics

CRISPR–Cas-based live cell imaging of genome dynamics

Nature Reviews Genetics, Published online: 08 April 2026; doi:10.1038/s41576-026-00949-zIn this Review, Zhu et al. outline the various CRISPR-based tools recently built for dynamic DNA and RNA imaging, which have provided insights into various molecular mechanisms. The authors also discuss the important parameters to consider when using these tools, and how to approach the quantitative image analysis.

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Incredibly proud of lead author Dr. Yanyu Zhu @yanyuzhu.bsky.social for this impressive review on CRISPR imaging of the genome. Honored to collaborate with Prof. W.E. Moerner. #CRISPR #GenomeDynamics #Imaging #3DGenomics @bioe-stanford.bsky.social @stanford-chemh.bsky.social @natrevgenet.nature.com

CRISPR–Cas-based live cell imaging of genome dynamics - Nature Reviews Genetics

In this Review, Zhu et al. outline the various CRISPR-based tools recently built for dynamic DNA and RNA imaging, which have provided insights into various molecular mechanisms. The authors also discu...

nature.com

@yanyuzhu.bsky.social · 7mo ago

(1/6) Watch the genome "dance" in real time. Our review in @natrevgenet.nature.com explores the CRISPR tools making it happen. Grateful for the guidance by Prof. Lei Stanley Qi @stanleyqilab.bsky.social and Prof. W.E. Moerner @moernerlab.bsky.social! #CRISPR #GenomeDynamics #Stanford #Imaging

For centuries, the microscope showed us the genome's static architecture. But the genome is not a static blueprint; it’s a living choreography. It breathes, communicates, and decides in real-time. To understand it, we must watch it MOVE. (1/5)

Ever heard of 'cellular nibbling'? In our @NatureCellBio paper, we’ve turned trogocytosis into a delivery tool for programmable medicine. Congrats to @xinyi-chen.bsky.social and team! Link: rdcu.be/fa90i @StanfordBioE @StanfordChEMH @CZBiohub #GeneTherapy #SyntheticBiology

Programmable macromolecule delivery via engineered trogocytosis

Nature Cell Biology - Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in...

rdcu.be

We’re excited to share that Maylin Fu, Ph.D. student in the Qi Lab, has been accepted into the NIH-funded Pathways to Neurosciences program at Stanford, supported by the Wu Tsai Neurosciences Institute. #Neuroscience #QiLab #WuTsaiNeuroscienceInstitute neuroscience.stanford.edu/programs/pro...

We’re happy to share our new paper in Genome Biology led by Lingling Wu and Xiang Wu, in collaboration with Xueqiu Lin lab at Fred Hutch. Parallel whole-genome CRISPRi screens in primary human MSCs map distinct regulators of aging processes across organs. #Aging #CRISPRi #Senescence

Thrilled to share our paper in @nature.com led by @MengtingHan123 on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford

Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social

Thrilled to share our preprint led by @xinyi-chen.bsky.social on programmable molecule delivery via engineered trogocytosis called TRANSFER! a 🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social

We are excited to make #CRISPR accessible to high school education. 🧬 Go check out the article in The Stanford Daily to read about our frugal CRISPRkits. #democratizingscience #scienceaccessibility @bioe-stanford.bsky.social @stanford-chemh.bsky.social stanforddaily.com/2025/02/03/c...

Bioengineering lab provides affordable gene-editing kits

Stanford researchers introduced affordable gene-editing kits ready for the classroom, aiming to make the field more accessible for high school students.

stanforddaily.com