Genomic, epigenomic and transcriptomic regulation of cellular senescence

Nature Reviews Genetics, Published online: 29 July 2026; doi:10.1038/s41576-026-00982-ySenescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, maintenance and propagation, highlighting the need for revised mechanistic frameworks and biomarkers to define and target senescent cells.

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Folding a broken genome: the versatile roles of cohesin in genome maintenance

Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.

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Embracing non-linearity in human ageing

Nature Reviews Genetics, Published online: 03 August 2026; doi:10.1038/s41576-026-00993-9Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such evidence across molecular and physiological systems and discuss analytical frameworks to identify non-linear transitions.

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Towards quantifying immune diversity through HLA genomics

Nature Reviews Genetics, Published online: 31 July 2026; doi:10.1038/s41576-026-00996-6Computational metrics such as HLA evolutionary divergence offer new ways to quantify functional variation in antigen presentation. In this Comment, the authors discuss how population-scale genomics can benchmark these approaches and assess their potential as quantitative measures of human immune diversity.

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Bidirectional functional genomics using CRISPR-KOALA

Nature Reviews Genetics, Published online: 31 July 2026; doi:10.1038/s41576-026-00997-5In this Tools of the Trade article, Khalid Al-Zahrani introduces CRISPR-KOALA, a new CRISPR-based platform that enables simultaneous loss- and gain-of-function screening in vivo, helping to pinpoint cancer driver genes hidden within large chromosome-scale copy number alterations.

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Human genetics across levels of biological organization

Nature Reviews Genetics, Published online: 23 July 2026; doi:10.1038/s41576-026-00991-xGenetic variation influences biological processes across scales; however, deciphering how effects propagate from molecules to whole organisms remains a key challenge in human genetics. In this Review, Laman Trip and Beltrao discuss how to link genetic variation to mechanisms across interacting biological levels using network, single-cell and imaging approaches.

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Genomic, epigenomic and transcriptomic regulation of cellular senescence

Nature Reviews Genetics, Published online: 29 July 2026; doi:10.1038/s41576-026-00982-ySenescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, maintenance and propagation, highlighting the need for revised mechanistic frameworks and biomarkers to define and target senescent cells.

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Genetic analysis of imaging-derived phenotypes

Nature Reviews Genetics, Published online: 06 July 2026; doi:10.1038/s41576-026-00989-5When integrated with genetic data, imaging-derived phenotypes (IDPs) enable large-scale analyses of genotype–phenotype relationships. Bian and Akey review analytical approaches to derive IDPs, key biological insights from genetic studies of imaging traits and emerging challenges in the rapidly evolving field of imaging genomics.

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Building and applying pangenome references to capture genetic diversity

Nature Reviews Genetics - Pangenomes are genome references that integrate sequences from multiple individuals into graph-based or multi-haplotype representations, capturing genetic variation beyond...

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Stomata — guarding the gates against bacterial invasion

Nature Reviews Genetics, Published online: 16 July 2026; doi:10.1038/s41576-026-00994-8In this Journal Club, Tatsuya Nobori recalls a landmark paper by Melotto et al., who showed that stomata are active components of plant innate immunity rather than passive entry points for bacterial pathogens.

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Human genetics across levels of biological organization

Nature Reviews Genetics, Published online: 23 July 2026; doi:10.1038/s41576-026-00991-xGenetic variation influences biological processes across scales; however, deciphering how effects propagate from molecules to whole organisms remains a key challenge in human genetics. In this Review, Laman Trip and Beltrao discuss how to link genetic variation to mechanisms across interacting biological levels using network, single-cell and imaging approaches.

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Building and applying pangenome references to capture genetic diversity

Nature Reviews Genetics, Published online: 29 June 2026; doi:10.1038/s41576-026-00987-7Pangenomes are genome references that integrate sequences from multiple individuals into graph-based or multi-haplotype representations, capturing genetic variation beyond a single linear reference. Here the authors review advances in assembling and applying human pangenome references, highlighting tools, insights and remaining challenges.

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Building and applying pangenome references to capture genetic diversity - Nature Reviews Genetics

Pangenomes are genome references that integrate sequences from multiple individuals into graph-based or multi-haplotype representations, capturing genetic variation beyond a single linear reference. H...

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Folding a broken genome: the versatile roles of cohesin in genome maintenance

Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.

dlvr.it

Stomata — guarding the gates against bacterial invasion

Nature Reviews Genetics, Published online: 16 July 2026; doi:10.1038/s41576-026-00994-8In this Journal Club, Tatsuya Nobori recalls a landmark paper by Melotto et al., who showed that stomata are active components of plant innate immunity rather than passive entry points for bacterial pathogens.

dlvr.it

Building and applying pangenome references to capture genetic diversity

Nature Reviews Genetics, Published online: 29 June 2026; doi:10.1038/s41576-026-00987-7Pangenomes are genome references that integrate sequences from multiple individuals into graph-based or multi-haplotype representations, capturing genetic variation beyond a single linear reference. Here the authors review advances in assembling and applying human pangenome references, highlighting tools, insights and remaining challenges.

dlvr.it

Folding a broken genome: the versatile roles of cohesin in genome maintenance

Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.

dlvr.it

Genetic analysis of imaging-derived phenotypes

Nature Reviews Genetics, Published online: 06 July 2026; doi:10.1038/s41576-026-00989-5When integrated with genetic data, imaging-derived phenotypes (IDPs) enable large-scale analyses of genotype–phenotype relationships. Bian and Akey review analytical approaches to derive IDPs, key biological insights from genetic studies of imaging traits and emerging challenges in the rapidly evolving field of imaging genomics.

dlvr.it

Genetic origins and constraints of evolutionary innovation

Nature Reviews Genetics, Published online: 19 June 2026; doi:10.1038/s41576-026-00983-xEvolutionary innovation emerges through the interplay of genetic novelty, genomic architecture and evolutionary constraint. Nature Reviews Genetics presents a Focus issue that explores the mechanisms that generate, integrate and shape biological diversity.

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Genetic analysis of imaging-derived phenotypes

Nature Reviews Genetics, Published online: 06 July 2026; doi:10.1038/s41576-026-00989-5When integrated with genetic data, imaging-derived phenotypes (IDPs) enable large-scale analyses of genotype–phenotype relationships. Bian and Akey review analytical approaches to derive IDPs, key biological insights from genetic studies of imaging traits and emerging challenges in the rapidly evolving field of imaging genomics.

dlvr.it

Single-cell four-omics with CHARM

Nature Reviews Genetics, Published online: 12 June 2026; doi:10.1038/s41576-026-00986-8In this Tools of the Trade article, Yujie Chen describes CHARM, a single-cell four-omics sequencing method that profiles genome conformation, chromatin accessibility, histone modifications and gene expression.

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Molecular integration of seasonal temperature signals in flowering time control

Nature Reviews Genetics, Published online: 11 June 2026; doi:10.1038/s41576-026-00979-7Plants must accurately time flowering by integrating seasonal temperature cues to ensure reproductive success. This Review describes how two mechanisms — rapid transcriptional responses and long-term epigenetic memory — work together in parallel to robustly control flowering time, and it highlights that variation in these processes provides important information for the future of crops under a changing climate.

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Evolutionary causes and consequences of gene duplication

Nature Reviews Genetics - Gene duplication is a key evolutionary mechanism, as initially redundant paralogues diverge over time. The authors review how adaptive and non-adaptive forces influence...

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RBPscan measures protein–RNA interactions in living cells

Nature Reviews Genetics, Published online: 08 June 2026; doi:10.1038/s41576-026-00985-9In this Tools of the Trade article, Dmitry Kretov and Daniel Cifuentes describe RBPscan (RNA-binding protein specificity and contextual analysis via nucleotide editing), a method that measures the strength of in vivo interactions between RNA binding proteins and their RNA targets.

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Genetic origins and constraints of evolutionary innovation

Nature Reviews Genetics, Published online: 19 June 2026; doi:10.1038/s41576-026-00983-xEvolutionary innovation emerges through the interplay of genetic novelty, genomic architecture and evolutionary constraint. Nature Reviews Genetics presents a Focus issue that explores the mechanisms that generate, integrate and shape biological diversity.

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