STEMCELL Science News
@stemcellsciencenews.com
A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
Dr. William Van Nostrand, co-executive director of the University of Rhode Island's Ryan Institute for Neuroscience, has received a $1.5 million grant to study cerebral amyloid angiopathy, a condition common in older adults and people with #Alzheimer's disease. 📰 https://bit.ly/4wCFTep
Researchers identified WD repeat domain 72 (WDR72) as a #CancerStemCell marker that significantly correlates with high-risk of #neuroblastoma and poor prognosis in neuroblastoma patients. 🧠 📚 Read the #OpenAccess study: https://bit.ly/4z190JR
MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state. Researchers showed that MLL3 and MLL4 preserve #HematopoieticStemCell multipotency by preventing a default transition to a B-cell–like state. 🔖 https://bit.ly/4fEbcQ4
🆕 Scientists summarize the therapeutic significance of #MSCs for inflammatory bowel disease in the context of their interactions with various innate and adaptive immune cells, including #neutrophils, macrophages, dendritic cells, NK cells, B lymphocytes, and T lymphocytes. https://bit.ly/4gcJWIt
Looking for a PhD? Applications are now open for PhD positions at the Max Delbrück Center. 🧵 www.mdc-berlin.de/career/jobs/...
PhD Positions (m/f/d) in Biomedical Research
mdc-berlin.de
New in @cp-immunity.bsky.social! 📣 @harvardmed.bsky.social scientists with Drs. Christophe Benoist performed a mini-screen to assess the ability of a diverse panel of T cell receptors to drive peripheral differentiation of regulatory T (pTreg) cell differentiation. 🔓 https://bit.ly/4bqWucx
Researchers developed an ECM–inspired dielectric film that enhances energy storage by improving molecular polarization, suppressing charge leakage, and increasing electrical breakdown strength. https://bit.ly/4fDsn2Q
In this study, researchers leveraged #hPSC-derived cortical #organoids and xenografts to model an Alu-mediated exon 17 deletion in the SPAST gene, a frequent cause of hereditary spastic paraplegia with dementia. https://go.nature.com/4x8KZig
Dr. Rui Yang, a Research Vision Scholar at Texas Children's has been awarded the Burroughs Wellcome Fund Career Award for Medical Scientists. 🗞️ https://bit.ly/4fJwdaJ Dr. Yang’s research focuses on understanding the genetics of immune reactions that underlie #AutoimmuneDisease. Congratulations! 🥳
Researchers studied 63 individuals undergoing partial pancreatectomy who underwent preoperative OGTT with model-based assessment of β cell function and provided #pancreatic tissue for ex vivo islet isolation and glucose stimulation. 🧫 🔗 https://bit.ly/4yABBpc
New from @ucsandiego.bsky.social! 📣 Researchers constructed a multimodal cell atlas of 36 human hearts spanning atrial and ventricular chambers, cataloging major #cardiac cell types and their associated disease states. ❤️ https://bit.ly/3S0Ljke Read the article in @science.org📖
This study uncovers a novel pathogenic axis in liver sinusoidal microthrombosis formation, where COX-2 drives a prothrombotic switch in liver sinusoidal #EndothelialCells via metabolic reprogramming and epigenetic upregulation of TSP-1. 📚 Learn more: https://bit.ly/4fpxsgv
Investigators suggest that CDC20 contributes to prostate cancer progression, at least in part, through a c-MYC-associated PI3K-AKT signaling axis and support its potential relevance for prognostic assessment and therapeutic targeting. 🔬 https://bit.ly/4frmJAK
Ferroptosis represents a pivotal mechanism in the pathogenesis and therapeutic response of #BreastCancer. https://bit.ly/44MLpPn Targeting ferroptosis pathways offers a promising strategy to enhance treatment sensitivity, overcome drug resistance, and improve patient prognosis. 🎯
Scientists led by Drs. Qiang Lu and Michael Barish investigated the therapeutic potential of targeting mitotic kinesin KIF20A in #glioblastoma multiforme stem/progenitor cells. https://bit.ly/4gM7eFY
Researchers developed transgenic mice carrying Doxycycline-inducible Sleeping Beauty mutagenesis system (DiSBey) in primary T cells. 🐁 Using DiSBey, they conducted screens for genetic alterations enhancing T cell persistence under chronic antigen exposure. https://bit.ly/45iL2fq
Investigators at @kingscollegelondon.bsky.social investigated how the development of hepatocellular carcinoma impacts the molecular programmes of tissue-resident #Tregs. 🔬 https://go.nature.com/4fdh8On
Researchers identify dermal papillary #fibroblasts as drivers of persistent granulation tissue formation in junctional #epidermolysis bullosa, revealing TGFβ signaling as a promising therapeutic target. ▶️ https://bit.ly/44mjSnD
Dr. Maria Grazia Cusi and scientists provided the first unequivocal evidence of human CNS involvement by detecting Sindbis virus RNA directly in the cerebrospinal fluid of four autochthonous patients presenting with acute neurological symptoms. 🧠 👉 https://bit.ly/4ynUefS
Researchers demonstrated that histone deacetylase 10 was markedly up-regulated in bladder #cancer and inversely correlated with CD8+ T cells infiltration. 📈 @TheCancerLetter | https://bit.ly/4wGJ8RF
Researchers with Dr. Vincent Liu at @stanford.edu described a method leveraging somatic mitochondrial mutations to reconstruct clonal lineage relationships between cells in native human tissues. 🔬 https://bit.ly/4gE28M2
This review authored by Drs. Wuqiang Zhu and @mayoclinic.org collaborators focuses on #cardiomyocyte alignment as a critical design requirement for improving electrophysiological and regenerative outcomes in #hiPSC-cardiomyocyte based cardiac #CellTherapy. https://go.nature.com/4gBAvDe
Dr. Lydia Sorokin from the @uni-muenster.de has been awarded an ERC Proof of Concept Grant from the ERC to finance her “BraIN” project. 🧠 Her work addresses transporting active substances across the blood-brain barrier. 🩸 Congratulations! 🤩 🗞️ https://bit.ly/4pmQCqz
For #FluorescenceFriday - human induced pluripotent stem cells trying to differentiate into locus coeruleus-like neurons... pretty pink one on their way and stained for tyrosine hydroxylase 🔬🤩🧠. Image credits to @lieberinstitute.bsky.social Stem Cell core and Imaging Development team. So excited!
Novel #immunotherapy approaches such as T cell-engager therapies, CD40 agonists, and HSV-TK gene therapy have shown early promise for the treatment of #ProstateCancer. Read the review from Drs. Dallos, Gaffney, and @mskcancercenter.bsky.social collaborators. 📖 🔗 https://go.nature.com/4vRA5x7
🔬 Researchers identify an AP-1/KIT signaling axis that drives early colorectal tumorigenesis in APC/TP53-deficient human colon# organoids, revealing a potential target for early intervention. Learn more here: 🔖 https://go.nature.com/4h4vnaO
Using a breast-specific CYP4Z1-transgenic MMTV-PyMT mouse model, China Pharmaceutical University scientists show that CYP4Z1 accelerates tumor initiation, enlarges tumor size, promotes #metastasis, and expands tumor-initiating cell populations. 🐁 🔗 https://go.nature.com/4fglWUj
A growing body of evidence has confirmed the critical role of #CancerStemCells in tumor progression, drug resistance, and recurrence, which lays a solid foundation for the development of potential therapeutic targets and intervention strategies. 🎯 Give it a read: https://go.nature.com/4ycVpyN
