www.officeforstudents.org.uk/news-blog-an.... On visiting the USA last week several academic colleagues had got the impression that the UK was becoming increasingly illiberal. I would like to point them to this speech by arif ahmed which illustrates the UKs firm commitment to Academic freedom

www.medrxiv.org/content/10.1... Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/

Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction

Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic me...

medrxiv.org

nature.com/articles/s44161-025-00712-3 Interesting. But studies of GDF15 on cells used GDF15 made in mammalian cells which is always contaminated by TGFB family members (see PMID: 29161287) some of which are active at fmolar concs. Yeast or bacterially derived is fine. Qkine is good source

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α - Nature Cardiovascular Research

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

nature.com

Fantastic news. Processes designed to measure Research excellence should focus on whether research done at our universities is reproducible, represents a significant advance in understanding, and/or is actually or potentially useful. The rest is just prattle.

Patrick Vallance hits pause on Research Excellence Framework

Science minister announces review of controversial changes to research environment assessment

timeshighereducation.com

The @easdnews.bsky.social Novo Nordisk Foundation Prize #Diabetes

Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in thes...

cell.com

So very sad. Davo was a truly great endocrine scientist.

Wiebke Arlt@wiebkearlt.bsky.social · last yr.

Deeply saddened to hear about the passing of an all-time-great of endocrine research, David Mangelsdorf - I just saw him at #ENDO2025, a real shock! Read his obituary here www.utsouthwestern.edu/about-us/ass... @endocrinesociety.bsky.social @esendocrinology.bsky.social @socendocrinology.bsky.social

sciencedirect.com/science/arti... Great to see further evidence emerging supporting the pressing need for trials of preconceptional GDF15 desensitisation with metformin for prevention of severe nausea and vomiting of pregnancy in women with a previous history. Congrats to @drfejzo.bsky.social

Pre-pregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum

Severe nausea and vomiting of pregnancy and hyperemesis gravidarum are associated with adverse maternal, fetal, and child outcomes. The recurrence ris…

sciencedirect.com

www.nytimes.com/2025/06/26/o... Amazing to see this article appear in the NYT. I hope many of my fellow endocrinologists are reading it @endocrinesociety.bsky.social

Opinion | How the Gay Rights Movement Radicalized, and Lost Its Way

nytimes.com

OMG. This looks terrifying.

Eric Topol@erictopol.bsky.social · last yr.

In today's WSJ by their editorial board www.wsj.com/opinion/rfk-...

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

Mice lacking this amino acid lost 30% of their body weight

But eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.

nature.com

Had a great time at Lund university attending their Spring Meeting. Amused to see this poster outside the lecture theatre. Those old English universities: it’s hard to tell them apart 😊

📢 Job Vacancy! Institute of Metabolic Science @ims-mrl.bsky.social are looking for a Research Nurse to join their team. Applications open until 30th May! >>> For more info: bit.ly/4iIkrNo @cuhnhs.bsky.social @mrcepid.bsky.social @stephenorahilly.bsky.social @cambridgeuni.bsky.social

Indeed. And so ironic that while the new administration says it is very keen to understand the effects of food on health, their actions are resulting in the closure of one the US’s most effective labs in that area @kevinh-phd.bsky.social

Daniel Drucker@danieljdrucker.bsky.social · last yr.

The world of science needs more colleagues like Dr. Kevin Hall. Honesty, integrity and high quality science, answering critical questions with broad implications for improving human health

www.thefp.com/p/carole-hoo.... While I applaud Harvard for standing up to the Trump government, this article is mandatory reading for anyone who doesn’t understand how it got to this point.

Carole Hooven: Why I Left Harvard

After I stated banal facts about human biology, I found myself caught in a DEI web, without the support to do the job I loved. The only way out was to leave it.

thefp.com

UK’s supreme court rules that legal definition of woman is based on biological sex. This is a hugely important decision. Unanimous .I hope it will open up rational debate in other countries.

I really enjoyed recording one of these with you several years ago. Wishing you well with whatever your next venture will be.

Ushma Neill@ushmaneill.bsky.social · last yr.

All good things must come to an end, including this brilliant series that I was delighted to have hosted. Hope you all have enjoyed it as much as I did! Thank you @jclinical-invest.bsky.social ! And all the Giants who trusted me to help tell their stories.

Almut Gadow v Open University genderblog.net/almut-gadow-... This piece is from Nick Wallis, the journalist whose doigged research exposed the Post Office Scandal. He is now taking a serious interest in an area that is increasingly affecting UK universities.Worth a read

Almut Gadow v Open University

Almut Gadow Dr Almut Gadow has a personality similar to those I’ve stumbled across a lot whilst talking to people about gender ideology. She’s fiercely intelligent, does not back down a…

genderblog.net

Come and study with us for a Masters!

Institute of Metabolic Science-Metabolic Research Laboratories@ims-mrl.bsky.social · last yr.

@ims-mrl.bsky.social @uniofcam.bsky.social full-time taught MPhil in Obesity, Endocrinology and Metabolism for 2025/2026 Application deadline 4th April!!! High quality postgrad training in physiology & pathophysiology of energy balance & metabolism. 🛜 mrl.ims.cam.ac.uk/study-us/tau...

x.com/shahrarali/s...

Shahrar Ali on X: "Fiery speech @ChrisDaviesLD pulling no punches, calling out impact upon impressionable youth of sex denialism, unfettered social contagion & failure of medical due diligence. Truth will cut through in end, once we've properly dispensed with no debate. https://t.co/SlXvgnn4mx" / X

Fiery speech @ChrisDaviesLD pulling no punches, calling out impact upon impressionable youth of sex denialism, unfettered social contagion & failure of medical due diligence. Truth will cut through in end, once we've properly dispensed with no debate. https://t.co/SlXvgnn4mx

x.com

www.theguardian.com/commentisfre...

The Observer view on gender data: failure to accurately record biological sex harms us all | Observer editorial

A report lays bare the extent of real-world detriment caused by institutions that have caved in to activist pressures

theguardian.com

The absence of data on biological sex is an affront to reality www.thetimes.com/article/7463...

The absence of data on biological sex is an affront to reality

The 226-page report into how official data on sex and gender is recorded, by Professor Alice Sullivan of University College London, exposes shocking gaps in public records due to confusion between

thetimes.com

Honoured to be in Baden-Baden to receive the Berthold Medal from the German Endocrine Society and give the abet gold lecture. Really great questions from a wonderfully engaged and responsive audience. Thanks to #JensBruining for his very kind introduction.

x.com/sexmattersor...

Sex Matters on X: "“Everybody, regardless of their politics, needs accurate data.” @ProfAliceS speaks to @JustinOnWeb @BBCr4today about the #SullivanReview 📻 https://t.co/BSR8ls60pP" / X

“Everybody, regardless of their politics, needs accurate data.” @ProfAliceS speaks to @JustinOnWeb @BBCr4today about the #SullivanReview 📻 https://t.co/BSR8ls60pP

x.com

This International Women's Day, we celebrate as women advocate for change, equity, & inclusivity paving the way for future generations of women scientists Meet Agnes Lukasik, Patient and Public Involvement & Engagement Manager @ims-mrl.bsky.social #IWD2025 #AccelerateAction @mrcepid.bsky.social

www.city-journal.org/article/new-... I was shocked when a recent Perspective in @NEJM disregarded the most thorough, unbiased, science-based assessment of the risk/benefits of taking a pharamacological approach to minors asking for help in relation to their biological sex/

The Corruption of The New England Journal of Medicine

A leading medical journal has capitulated to transgender activists.

city-journal.org

adiposetissue.org: A knowledge portal integrating clinical and experim... www.sciencedirect.com/science/arti... Thanks to the authors for providing a great online tool for the community

www.nature.com/articles/s41.... Interesting but report of liver autonomous effects of MC3R a bit surprising given the very low expression of MC3R in liver, at least in humans

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity - Nature Communications

Systemic lipid homeostasis requires hepatic autophagy to recycle intracellular fat. Here, the authors identify peripheral mechanisms regulating energy homeostasis, showing that MC3R is a regulator of ...

nature.com

www.science.org/content/arti... Unless he radically changes his approach, which seems unliely, this could be very bad news for US public health and biomedical science. He is actvely campaiigning againsyt HPV vaccination which is abolishing cervical cancer and mainatining an excellent safety record

Senate confirms Robert F. Kennedy Jr., a vaccine opponent, as health secretary

Controversial attorney will oversee vast health research and drug safety programs

science.org

see nationally commissioned and extremely rigorous Cass Report ( cass.independent-review.uk/home/publica...)

Final Report – Cass Review

cass.independent-review.uk

Stephen O'Rahilly@stephenorahilly.bsky.social · 2y ago

www.nejm.org/doi/full/10.... . States that gender affirming care (incl puberty blockers and cross-sex hormones in minors) is "essential, evidence-based, and often lifesaving". In no other field would the @NEJM advocate for therapies with such a weak evidence base.