We have made historic strides in sequencing the human genome, but the legacy "one gene, one disease" paradigm has blinded us. 🧬A single genetic variant doesn’t always dictate a single disease box. One gene variant can alter how your cells react to other genes and the environment. #Genomics #rs5522

Things I enjoy: improv, travel, books. 🎭✈️📚 Things I never expected to be on my bingo card of life: discovering that most modern chronic disease is a preventable, inflammation-driven process triggered by an overactive mineralocorticoid receptor (MR) invisible on existing tests.

Eleanor Roosevelt was dismissed as a mere token appointment on the 1946 UN Human Rights Commission. Male peers assumed she lacked depth, but she was elected chair and out-maneuvered them through grueling work. By 1948, her execution earned a standing ovation for the finalized Declaration.

Kelly Guinan@kellyguinan.bsky.social · 3d ago

New, fun, one-minute learning, the modern School House Rock® of American History by @hcrichardson.bsky.social team #250to250 Universal Declaration of Human Rights Narrated by @hillaryclinton.bsky.social #WeAreAmerica250 #EleanorRoosevelt #Dignity #UnitedNations youtu.be/Fxsl0mrJbXg?...

One of the best acceptance speeches I've ever heard, given by FRED ROGERS upon receiving his Lifetime Achievement Award at the 1997 Emmy's. Beautiful stuff.

Are you suffering from unexplained fatigue, pain, and inflammation? What if your body is trapped in a physical nightmare because medicine is missing a hidden genetic driver? Millions are being told it’s in their heads and their labs are normal while their bodies collapse. Share & demand action.

Can I just say, c'mon people—didn't there have to be something fundamentally wrong with the tests we were using when millions of people with #ME/CFS or #LongCovid were told they had "normal" labs? Seriously. You think millions of people just decided to fake debilitating and crushing fatigue?

Once you realize that almost every major chronic disease is really just a raging bonfire of inflammation, the entire trillion-dollar circus suddenly clicks into focus. You stop seeing separate diseases, and you start seeing the downstream pattern of a massive corporate grift. #BioSky #MedSky

The Trillion-Dollar Grift: How Pharma Chose Profit Over Prevention

The Trillion-Dollar Grift: How Pharma Chose Profit Over Prevention

medium.com

I’ve been completely ME/CFS free for 10 months after 28 years of suffering. Yet, in the most underfunded disease space in history, the medical establishment is still entirely blind. They waste time on downstream symptoms while totally ignoring upstream receptor biophysics and MR/GR signaling.

Occam’s razor forces a choice: are there hundreds of distinct disease mechanisms requiring separate specialists, or does one mechanism—chronic inflammation from hyperactive mineralocorticoid receptors—manifest in myriad ways depending on which organ bears the greatest burden?

“Joy doesn't betray but sustains activism. And when you face a politics that aspires to make you fearful, alienated and isolated, joy is a fine act of insurrection.” ― Rebecca Solnit, Hope in the Dark: The Untold History of People Power

We celebrate Dolly Parton and Gloria Steinem for art, activism, and lifting up others. They served with grace and grit. Some in government claim our stake in this country relies on reproduction, but our greatest citizens prove otherwise. Our lives are measured by our impact, not our fertility.

“In everyone's life, there is great need for an anam cara, a soul friend. In this love, you are understood as you are without mask or pretension... Love allows understanding to dawn, and understanding is precious. Where you are understood, you are at home." ― John O'Donohue🇮🇪✨🌱

"You should write about take no-shit women like me. Girls need to know they can break the rules." ― Gloria Steinem, My Life on the Road

The New York Times@nytimes.com · last wk.

Breaking News: Gloria Steinem, the feminist crusader who galvanized the modern women’s movement, challenged sexist assumptions and fought for gender equality, has died at 92. nyti.ms/4cVollO

Before losing her life in 1986 aboard Space Shuttle Challenger, Christa McAuliffe was set to be the first teacher in space with plans to teach a lesson to kids around the world from orbit. Today is her birthday, and even now, her courage and dedication to education continues to inspire.

In ancient Hindu texts, transgender people were revered as possessing divine status, yet transgender people in India face exclusion from temples and other sacred spaces. An activist responded by creating a Kali temple where transgender people can worship, gather, and find community.

A Transgender Woman's Spiritual Reclamation in India

Transgender activist Sowndharya Gopi built a Kali temple in Chennai, honoring and celebrating the spirituality of the transgender community.

fetzer.org

Barbara McClintock proved genes move, defying rigid dogmas. Derided & dismissed by peers in 1951, she stopped publishing & worked in isolation. Decades later, molecular proof vindicated her, winning her the 1983 Nobel Prize. Paradigm shifts are often met with hostility by those who don't understand.

Barbara McClintock: A-“maizing” Insights about Jumping Genes - Lasker Foundation

SEPT. 25, 2020Read about the revolutionary genetic discoveries that challenged established concepts.

laskerfoundation.org

“You must not lose faith in humanity. Humanity is like an ocean; if a few drops of the ocean are dirty, the ocean does not become dirty.” ― Mahatma Gandhi

Poverty is a policy choice. Concentrated wealth is a policy choice. Inequality is a policy choice. None of it is natural or inevitable. Remember: We have the power to build a system that serves the many, not the powerful few.

What loved ones did you lose to chronic disease in the 66 years since we have had the drugs to prevent the systemic inflammation caused by overactive MR receptors?The #rs5522 tissue starvation mechanics are real. Stop the suffering and premature death. www.beyondbloodtests.org

The biological mechanism of #MECFS was published in June (BBRC, Katsu 2026). The #rs5522 gene variant overactivates the MR receptors, stealing cortisol fuel from the GR receptors & shutting down mitochondrial energy. Standard tests miss this tissue starvation. Journalists: cover the science!

Comparison of transcriptional activation by corticosteroids of human MR (Ile-180) and haplotype (Val-180)

While the human mineralocorticoid receptor (MR) regulates electrolyte homeostasis through aldosterone activation of the kidney MR, the MR also is high…

sciencedirect.com

ME/CFS was the most underfunded disease, so I had to do the work myself, and I did. I found the driver. If they had funded it and taken it seriously, they would have seen the pattern linking it to other chronic illnesses and prevented countless suffering across dozens of diseases. #rs5522 #ME/CFS

High cholesterol, heart attacks, strokes, kidney disease, fatty liver. They are all driven by the exact same underlying inflammation, and we have literally had the ability to prevent these diseases for decades. Stop the unnecessary suffering. The science is there. It’s time to use it. #rs5522

Alzheimer’s, Parkinson’s, Huntington’s, MS, dementia. None of this is inevitable. The root driver is neuroinflammation, and we have literally had the ability to prevent these diseases for decades. Stop the unnecessary suffering. The science is there. It’s time to use it. #rs5522

Medicine is stuck in an organ-centric way of thinking. We are not cartoon men in an Operation game with isolated plastic parts.The body is a unified, biophysical matrix. Disease is driven at the cellular level by GR/MR receptor signaling and fluid dynamics, not siloed organs. Time to evolve. #rs5522

How long will you let pharma fleece you with expensive downstream symptom fixes when generic upstream blockers exist? Seriously? Occam’s razor: what's more likely? That the body developed 100 random diseases, or that a single MR receptor-driven inflammatory cascade is fueling them all?

The Trillion-Dollar Grift: How Pharma Chose Profit Over Prevention

The Trillion-Dollar Grift: How Pharma Chose Profit Over Prevention

medium.com

Radical honesty: I grew up loving theater, books, and the arts. I hated the science fair. But chronic illness forced me to become an expert to survive. My humanities training is why I saw the big picture loops the medical world missed. It sucks ass waiting for an entire establishment to catch up.

How UX Thinking Helped Me Solve Chronic Disease (And Why AI Can’t)

The Star Trek Pill

medium.com

While we celebrate the lives of great artists who brought so much creativity & joy to our lives, don't you wonder why some people live longer and some die too soon? Inflammation. It's the master process that causes damage to vessels and sets disease in motion. It shaves years off of life spans.

The Billionaire’s Blind Spot: Why Peter Thiel’s Millions Won’t Buy Him Immortality

There are a lot of reasons not to like Peter Thiel.

medium.com

Medicine's biggest fallacy is the one-gene-per-disease myth. 🧬 The same variant #rs5522 causes different diseases depending on other genes & environment. If you only look for differences, you miss it. Because the Mineralocorticoid Receptor is everywhere, the effects of an overactive MR will cascade.

Happy Saturday. It's been a moment since I reminded you that all modern disease is preventable inflammation driven by the #rs5522 genetic variant. 🧬 I cured my #ME/CFS with a drug that's been around since 1960 and you have been sold a lie about obesity. Remember correlation is not causation.

Patricia Donnellan, MPH 🇺🇦📎@stpaulsbay.bsky.social · last mo.

Modern chronic disease is driven by systemic inflammation: our primary anti-inflammatory brake is slipping. The culprit? The dominant #rs5522 baseline. Found in 80% of us, it hoards cortisol and overactivates MR, leaving the GR (Glucocorticoid Receptor) brake compromised. www.beyondbloodtests.org 🧬

Tired of this administration’s fake patriotism while they make weird ass decrees. Lincoln comes to mind: “... I should prefer emigrating to some country where they make no pretense of loving liberty—to Russia, for instance, where despotism can be taken pure, and without the base alloy of hypocrisy.