🛠️ Even the most carefully managed IT environments need to be prepared for the unexpected. In #CryoSPARC v5, we introduced Instance Recovery, a built-in recovery system for unforeseen database loss or corruption, adding another layer of resilience to our #cryoEM software. Read more 👉 bit.ly/4xlZMGS

📽️ Did you miss our talk at the Spring CCP-EM Symposium 2026? You can now watch the full talk from Structura, where we share some of the latest and upcoming developments in #CryoSPARC and single-particle #cryoEM: Check out the full talk here 👇 www.youtube.com/watch?v=Rilg...

New Developments for Single Particle Cryo-EM Data Processing in CryoSPARC | Ali Punjani (Structura)

YouTube video by CCP-EM

youtube.com

🔬Malaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane Remodeling In a recent Cell publication, researchers at Columbia University resolved the endogenous structure of the malaria moving junction staple using #cryoEM. Read more in the #CryoSPARC Blog 👉 bit.ly/46aX6jl

🚀 Preprint alert: cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle #CryoEM Explore how cFAR, tFAR, and Relative Signal provide complementary diagnostics for preferred orientation, tested across 14 #EMPIAR datasets and compared with established metrics 👉 bit.ly/4wBY1Ev

🔄 Mixing Two Cryo-EM Datasets on Purpose: A Cryo-EM Heterogeneity Challenge What happens when you deliberately mix two #cryo-EM datasets containing different conformational states? Our latest #CryoSPARC blog distills the practical lessons from the accompanying FaNaC1 case study 👉 bit.ly/3ScIZa3

🇨🇦 This week we’re at IUCr 2026 in Calgary! Join us during Poster Session 4B (Sunday 15th, 5-6 PM MDT), at poster #486, where we’ll be presenting: 🔹 Updates and upcoming developments in #CryoSPARC 🔹 Advances in automated #cryo-EM data processing 👉 www.iucr2026.org

Introducing CsMT: A new CryoSPARC workflow for high-resolution microtubule reconstruction based on novel PF-pair classification! You can reconstruct MTs entirely in CryoSPARC—zero custom scripts needed. Inspired & built through a fantastic collaboration with the Cianfrocco lab! tinyurl.com/kdpm86tw

✨ We’re at the Microscopy & Microanalysis conference in Milwaukee (WI) this week! Join us during session B04.2, where we’ll be showcasing recent #CryoSPARC developments and discussing the latest advances in single-particle #cryoEM data processing and analysis. 👉 mmconference.microscopy.org

🔬 Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis! Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin

✨ We’ll be at the Structure-Based Drug Design Summit in Boston this week, showcasing recent #CryoSPARC developments for industrial applications in #cryoEM and #SBDD. If you're attending, we'd love to connect! structure-based-drug-design-summit.com

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG

🧩 Why can two refinements with very different particle counts produce nearly identical maps? Our new “Digging Deeper” series breaks down #CryoSPARC case studies in a practical way, starting with how refinement parameters shape reconstruction quality. Read more 👉 cryosparc.com/blog/paramet...

A reminder that registration closes on July 24th!

Structura Biotechnology@structurabio.bsky.social · 2mo ago

🇨🇦 The Toronto-based #CryoSPARC Workshop in collaboration with SickKids is back this September! Dive deep into single particle data processing with the experts at Structura. 🗓️ When | Sept 24-25, 2026 📍Where | SickKids Patient Support Centre, Toronto Info and registration: cvent.me/dL1wem #cryoEM

🚀 New and expanded #CryoSPARC Guide pages are here! 📚 We present to you several new and updated pages, featuring new figures and explanations, along with learning materials designed for both new and advanced #cryoEM practitioners. Brief summary of what’s new in the thread!

✉️ The latest #CryoSPARC Newsletter is out! Highlights include: 🔹 Sept 2026 workshop hosted with SickKids 🇨🇦 🔹 New cryosparc-tools video 🔹 New case study on discrete heterogeneity 🔹 Small-protein #cryoEM advances 🔹 Dynamic masking guide (v5) Read more here: mailchi.mp/b8fb173dac5c...

🔬Using #SingleParticle #cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function. Read more in the latest #CryoSPARC Blog 👉 cryosparc.com/blog/gap-jun...

CryoSPARC | Mind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin Assemblies

Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction org...

cryosparc.com

🇨🇦 The Toronto-based #CryoSPARC Workshop in collaboration with SickKids is back this September! Dive deep into single particle data processing with the experts at Structura. 🗓️ When | Sept 24-25, 2026 📍Where | SickKids Patient Support Centre, Toronto Info and registration: cvent.me/dL1wem #cryoEM

CryoSPARC workshop in Toronto! Beyond consensus refinements: Advanced cryo-EM data processing with CryoSPARC Sept 24-25, 2026 (part of the Canadian Cryo-EM Nexus) Register here: cvent.me/dL1wem Please see details in the link or the image Alt text @structurabio.bsky.social @sickkidsto.bsky.social

☀️ Last week we had the pleasure of contributing to the UCSC #CryoEM Workshop in Santa Cruz with a hands-on #CryoSPARC data processing session. ✨ Thank you to the organizers and everyone who participated. We look forward to many more opportunities to contribute to workshops like this!

🚀 Can automation scale #cryoEM? We recently demonstrated it is possible to make #cryo-EM more routine and scalable testing across 21 challenging #GPCR datasets, a real-world scenario for #SBDD, achieving results equal or better than manual processing. Read more 👉 cryosparc.com/blog/automat...

CryoSPARC | Automated Workflows in CryoSPARC™

How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processing

cryosparc.com

☀️ Structura will be at the UCSC CryoEM Workshop in Santa Cruz this week, leading a hands-on workshop on #cryoEM #SingleParticleAnalysis with #CryoSPARC. Looking forward to exchanging ideas and strategies, and chatting about all things cryo-EM! See you there!🔬 👉 sites.google.com/view/ucsccry...

In a recent #NatComm study, researchers leveraged high-resolution #cryoEM structures of the κ-opioid receptor bound to difelikefalin to guide the design of a more selective compound with reduced side-effect potential. 👉 cryosparc.com/blog/kor-sbdd #StructuralBiology #SBDD #CryoSPARC

CryoSPARC | Scratching Beneath the Surface: Cryo-EM Guides New Opioid Drug Design

Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.

cryosparc.com

🔍 Sample heterogeneity is both a challenge and an opportunity in #cryoEM data processing. In our latest #CryoSPARC case study we explore EMPIAR-10927, a dataset with acetogenin-bound mitochondrial Complex I, that reveals many more complexes according to the data processing strategy 👉 bit.ly/4uihh8V

Case Study: Discrete heterogeneity in a sample of Acetogenin-bound complex I (EMPIAR 10927) | CryoSPARC Guide

Processing EMPIAR-10927 including separating targets using Per-particle scales or custom settings in Ab-Initio Reconstruction, and using 3DVA to guide sub-classification choices.

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🦠 How does the human immune system defeat measles? #cryoEM and #CryoSPARC reveal the answer. 🔬 A recent study from @lji.org provides new insights into how the human immune system recognizes and neutralizes measles virus. Read more in the latest #CryoSPARC Blog 👉 cryosparc.com/blog/measles

CryoSPARC | A New Step in the Fight Against Measles

How Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virus

cryosparc.com

For years, the #cryoEM community viewed ~50 kDa as the practical lower size limit for SPA. This was challenged by Kim et al., who introduced the HR-HAIR method and demonstrated structure determination of proteins below 30 kDa using #CryoSPARC. Read more 👉 bit.ly/3RHMxAt

CryoSPARC | The Resolution Revolution Is Still Ongoing

High-Resolution Ab-Initio Reconstruction: Extending Cryo-EM to Smaller Particles with CryoSPARC™

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🚀 We're excited to announce the stable release of CryoSPARC v5! After a successful public beta and months of testing, we’re excited to share this major milestone, made possible by feedback from the amazing #CryoSPARC community. Learn more 👉 cryosparc.com/blog/v5-0-st... #cryoEM #StructuralBiology

🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!

cryosparc-tools is a standalone Python library that connects to #CryoSPARC and is designed to advance your #cryoEM data processing via scripting. 🚀 Watch this new video for an overview of cryosparc-tools, and explore the resources linked in the description 👉 youtu.be/QY7t67c9bQ8

CryoSPARC Tools: Simple scripting for advanced cryo-EM processing

YouTube video by Structura Biotechnology Inc.

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What is the value of open data for the life sciences? 📈 New report by Frontier Economics shows that EMBL-EBI data resources save users an average of 11 hours/week/person, leading to £11.8bn/year in research productivity gains. s.embl.org/EMBL-EBI-202... #opendata

What an incredible #Cryo-EM SPA mini-course last week, hosted by @royalmicrosoc.bsky.social & ThermoFisher Scientific! 🚀 Huge thanks to all the participants who joined the webinar, and to the experts who shared their insights on #SingleParticle #cryoEM workflows.