Subham Mridha
@subhammridha.bsky.social
A student of science -trying many things at a time Postdoc @UPenn Postdoc & PhD @UniZurich MSc & BSc @PresidencyKolkata
Some genomic inversions can persist for millions of years. This study by @judithmank.bsky.social @vdbijl.bsky.social & Yuying Lin reveals how ecological conditions and mate choice help maintain this hidden layer of #genomic diversity in guppies. 🧪#evolution #academicSky buff.ly/6sEgmgT
So very, very happy to see this out @plosbiology.org : Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations. Beautiful work by two very clever and talented coauthors, Yuying Lin and @vdbijl.bsky.social . journals.plos.org/plosbiology/... 1/
Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations
Genomic inversions spanning many genes can persist for millions of years. This study of Trinidadian guppy populations reveals how both ecological conditions and mate choice help maintain this hidden l...
journals.plos.org
Our results demonstrate that a combinatorial immune-microbiota-based approach can treat infections. This is just the trailer, stay tuned for the final show!! Real team effort, I am grateful to all people involved in this study @upenn.edu #Immunotherapy #Microbiome #MicrobiotaBasedTherapy #Cdiff
Subham Mridha@subhammridha.bsky.social · 2w agoOur latest preprint shows immunotherapy can reduce intestinal inflammation and promote Fecal Microbiota Transplant (FMT) mediated clearance of C. difficile infection in mice. We determined key immune regulatory pathways critical for FMT engraftment.
Our latest preprint shows immunotherapy can reduce intestinal inflammation and promote Fecal Microbiota Transplant (FMT) mediated clearance of C. difficile infection in mice. We determined key immune regulatory pathways critical for FMT engraftment.
Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treat Clostridioides difficile
Microbiome-based therapeutics to treat enteric bacterial infections requires stable engraftment of transplanted beneficial bacteria that target and eliminate the pathogen. The host factors that determ...
biorxiv.org
Predation resistance mechanisms operate at an individual level, adaptations are sometimes pleiotropic and compensatory. Thanks to all my co-authors who made this research possible Ove, Sarah, Saskia, Bernd, @rkmicrobes.bsky.social @simonahuwiler.bsky.social #AMR #Bdello #Evolution tiny.cc/2qpa101
Outer membrane changes enable evolutionary escape from bacterial predation
Abstract. Antimicrobial resistance (AMR) is a threat to modern medicine. To combat AMR pathogens, natural predators like bacteriophages and predatory bacte
tiny.cc
Subham Mridha@subhammridha.bsky.social · 3w agoOur paper in @isme-microbes.bsky.social uncovers the genetic causes of predation resistance in bacteria, that predominantly occur through outer membrane changes. Adaptations are metabolically expensive. This has great implications in the clinical setting for use of #BALOs.
Our paper in @isme-microbes.bsky.social uncovers the genetic causes of predation resistance in bacteria, that predominantly occur through outer membrane changes. Adaptations are metabolically expensive. This has great implications in the clinical setting for use of #BALOs.
Simona Huwiler@simonahuwiler.bsky.social · 3w ago#AMR superbugs are getting tougher, but predatory bacteria like B. bacteriovorus can hunt them down! We show that model bacterium E.coli 🦠 can escape these ‘living antibiotic’ by evolution, mainly through OmpF porin loss. This comes at a cost. Details at: tiny.cc/2qpa101 #MicroSky, #Evolution
Our new review article elaboring on how siderophores can shape bacterial interactions and community building @simonmarech.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Our new study combines experiments with bioinformatics to examine amino acid metabolism in Pseudomonas strains co-isolated from pond and soil communities by Simon Maréchal, Beni Heiniger, @swagatika.bsky.social, Shaohua Gu, Christian Ahrens www.biorxiv.org/content/10.6...
biorxiv.org
Our first study on clinical isolates: genetic, phenotypic and behavioural patterns among P. aeruginosa, S. aureus, and H. influenzae from children with CF @schluk.bsky.social @friendlymicrobe.bsky.social @serenaprovveduto.bsky.social Markus Hilty Philipp Latzin etal www.biorxiv.org/content/10.6...
biorxiv.org
Multiple small, curved, predatory bacteria (Bdellovibrio bacteriovorus) lyse the bacterial prey remnants below. How are they doing this & which predator proteins are involved in this process? See our newly released research article 📑 => rdcu.be/eL6gu 🦠 #microsky #bacteria #PredatoryBacteria
We are looking for a highly motivated postdoc to work on pathogen interactions. Please send in your application via jobs.uzh.ch/job-vacancie...
UZH: Postdoctoral researcher in microbiology
The Department of Quantitative Biomedicine is an interdisciplinary biomedical research unit that combines basic science with biotechnological and medical research, using both experimental and computat...
jobs.uzh.ch
Our opinion piece on the role of microbial siderophores for One Health is now out with Zhong Wei, Shaohua Gu, Yuanmei Zuo, Zhiyuan Li and @veraeva.bsky.social www.cell.com/trends/micro...
Microbial siderophores for One Health
One Health is an integrative concept striving for healthy environments, animals, and humans. Microbes play a fundamental role for this concept as they are key drivers of ecosystem stability and host h...
cell.com
Ten more days to apply! Join us in Bayreuth to study how burying beetles use social behaviors to control harmful and beneficial microbial communities during family life!
Jos Kramer@joskramer.bsky.social · last yr.🎓 #PhD in Evolutionary Ecology @UniBayreuth 🇩🇪 Parental care vs microbe communities in burying beetles 🪲🧫 ERC-funded | 3 years | behavioral ecology & metabarcoding Details: tinyurl.com/CareVsMicrobes Apply by May 16, start in September #AcademicSky #Microbiome #SocialEvolution #Insects
1/ Happy to share our latest preprint on modulating gene expression and protein secretion in predatory bacterium Bdellovibrio bacteriovorus. #MicroSky #SyntheticBiology #PredatoryBacteria Short thread below. (📑 Preprint at: www.biorxiv.org/content/10.1...)
Modulating gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus
The predatory bacterium Bdellovibrio bacteriovorus kills and consumes other bacteria, thrives in diverse environments and holds great potential to address major challenges in medicine, agriculture, an...
biorxiv.org
🛠️Toolbox 🛠️ out to modulate gene expression & protein secretion in a predatory bacterium. 📑Preprint from my group below. Many thanks to L. Mihajlovic @ljmihajlovic.bsky.social, L. Hofacker, F. Lindner, P. Jayakumar & A. Diepold @diepold-lab.bsky.social! #MicroSky #SyntheticBiology #PredatoryBacteria
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.Modulating gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus https://www.biorxiv.org/content/10.1101/2025.05.17.654431v1
Hello friends, I am excited to host the seminar “Introduction to R for Beginners” on the instats.org platform on the 5-6th May 2025 (11am - 5pm EDT). This is a good opportunity, if you want to get started with R and use it for data analysis. Kindly share. instats.org/seminar/intr...
Introduction to R for Beginners - Live-streaming:
This Instats seminar on Introduction to R for Beginners taught by Subham Mridha will help you take your research to the next level. Sign up today!
instats.org
New Instats livestreaming seminar: Introduction to R for Beginners #Biology #Microbiology #Interdisciplinary #Education #Statistics #DataScience #R #Research #ResearchTraining #Instats
Introduction to R for Beginners - Livestream starting May 5, 2025 (UTC)
Unlock new research capabilities with our upcoming two-day workshop on mastering R for data science! Led by Dr. Subham Mridha from the University of Pennsylvania and the University of Zurich, this beginner-friendly workshop is perfect for PhD students, postdocs, academics, and professional researchers eager to enhance their data analysis and visualization skills. Dive into the world of R and R Studio, learn to import and organize datasets, harness the power of the "tidyverse" and "ggplot2" libraries, and perform complex statistical analyses to transform your research outcomes. This hands-on experience will empower you to present impactful data visualizations and ensure the reproducibility and transparency of your research. Join us via Zoom and gain an invaluable addition to your academic toolkit, complete with seminar recordings, materials, and expert Q&A support available for 30 days post-seminar. Participants will receive an official certificate of completion, and European students can earn ECTS Equivalent points. Don't miss this chance to make a significant leap in your data science journey. Sign up now and transform how you work with data! #Biology #Microbiology #Interdisciplinary #Education #Statistics #DataScience #R #Research #ResearchTraining #Instats
instats.org