🚀 Dynamic plots of Alzheimer's disease biomarker relationships! 🧠 alz-journals.onlinelibrary.wiley.com/doi/10.1002/... 🌧️ Rain drops (amyloid.shinyapps.io/ADNI_Raindro...): Relationships between the baseline rank of one biomarker and the interpolated value of a second biomarker over time.

🚀 Dynamic plots of Alzheimer's disease biomarker relationships! 🧠 alz-journals.onlinelibrary.wiley.com/doi/10.1002/... 🏹 Time trails (amyloid.shinyapps.io/ADNI_Time_Tr...): Relationships between two biomarkers are interpolated over time.

⏱️ What is the “door-to-needle” time for amyloid-targeting treatments? 🧠 A new paper led by Anna Hofmann from the Washington University Memory Diagnostic Center examined this in a real-world memory clinic setting. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Submit your research to #DADM Special Issue! 2nd Edition: Real-World Evidence on Amyloid-Targeting Treatments: Early Data on Clinical Implementation, Safety, and Efficacy ⏰Deadline: Oct. 31, 2026 alz-journals.onlinelibrary.wiley.com/hub/journal/... Guest Editor: @suzanneeschindler.bsky.social

1️⃣ A plasma model combining %p-tau217 and eMTBR-tau243 showed high concordance with PET-based biological staging across independent cohorts.

New publication in JAMA Neurology! 🧠 In this study, led by @gsalvado.bsky.social, we developed and validated a plasma-based biological staging model for Alzheimer’s disease using two blood biomarkers: %p-tau217 and eMTBR-tau243. jamanetwork.com/journals/jam...

Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease

This longitudinal study develops and validates a blood plasma–based biological staging model for Alzheimer disease that closely mirrors an amyloid and tau positron emission tomography–based staging sy...

jamanetwork.com

🧠 Real-world data from the Washington University Memory Diagnostic Center on clinical use of Alzheimer's disease biomarker tests in 1,136 patients: doi.org/10.1002/alz.... Biomarker testing increased by 7-fold over four years; females and White individuals had higher rates of biomarker positivity.

Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic

INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent ...

doi.org

New AI model can detect multiple cognitive brain diseases from a single blood sample www.lunduniversity.lu.se/article/new-... #Alzheimers #dementia #Parkinsons #ALS #FTD #stroke #science #NeuroSkyence #AI

This study was led by Beata Borgström Bolmsjö and Sebastian Palmqvist. A big thanks to all collaborators and co-authors! @suzanneeschindler.bsky.social

Biomarkers play a critical role in diagnosing Alzheimer’s disease.🧠 Join us on Feb. 26 at 1pm CT for a free webinar to learn about biomarkers,and get updates and tips to help you talk to your doctor and understand testing options. Register: https://bit.ly/4bGbapa.

🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin? nature.com/articles/s41...

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine www.nytimes.com/interactive/... #Alzheimers #dementia #science #neuroscience #NeuroSkyence

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article)

A quiet policy change means the government is making fewer bets on long-term science.

nytimes.com

Animated educational videos for clinicians that describe how to use biomarkers for Alzheimer's disease in clinical practice. Neurology in Motion: practicalneurology.com/videos/neuro... #ENDALZ #dementia

ICYMI: New online! Towards pharmacological prevention of Alzheimer disease

Towards pharmacological prevention of Alzheimer disease

Nature Reviews Neurology, Published online: 03 November 2025; doi:10.1038/s41582-025-01154-yAdvances in biomarkers, blood tests and disease-modifying therapies have created a credible path to clinical prevention of Alzheimer disease (AD). In this Perspective, the authors discuss promising approaches to the prevention of AD and highlight strategic gaps.

bit.ly

That's exactly why Randall J. Bateman, MD, was invited to @cbssundaymorning.bsky.social — see how our groundbreaking clinical trials could change the outcome for millions of people who live in fear of what Alzheimer’s takes from them: campaigns.med.washu.edu/alz

The FDA has cleared the first blood test for Alzheimer’s for use in primary care settings to rule out the presence of amyloid. “This is another important step toward expanding access to Alzheimer’s diagnostic tools." -Joanne Pike, Association president & CEO Read our full statement: bit.ly/4oh3Tiu

Alzheimer’s Association Welcomes FDA Clearance of First Blood Test for Use in Primary Care to Rule Out Alzheimer’s-Related Amyloid Pathology

Developed by Roche, this is the first blood test for use in primary care to rule out Alzheimer's-related amyloid pathology.

alz.org

My op-ed just came out discussing how NIH leadership is failing early career researchers and, importantly, how we can push back and take our future into our own hands.

NIH Leadership Is Failing Early Career Researchers

Halted training programs, funding chaos, and hiring freezes jeopardize advancement options for early career researchers.

the-scientist.com

Has your research funding been cut by the administration? Now is the time to raise your voices. I know we all know someone, even if we ourselves haven’t been personally affected (yet). Please share your story with @nytimes.com www.nytimes.com/2025/10/08/c...

Has Your Scientific Work Been Cut? We Want to Hear.

nytimes.com

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

New landscape of the diagnosis of Alzheimer's disease

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

thelancet.com

Review of Alzheimer's diagnostics from The Lancet: New landscape of the diagnosis of Alzheimer's disease www.sciencedirect.com/science/arti... #ENDALZ

We're proud to share that over the last year, we invested $112.2 million in our research programs—the largest single-year on record—bringing our total active & committed investments to over $450 million. Help us continue the momentum: alz.org/donate. #ENDALZ #BrainHealth

New paper from the lab. First author @mwelhaf.bsky.social, now in a TT position at North Carolina A&T. We wanted to know how environmental contexts and self-reported distractions impacted cognitive #EMA in older adults. mhealth.jmir.org/2025/1/e71578 1/n

Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

Background: Unsupervised cognitive assessments are becoming commonly used in studies of aging and neurodegenerative diseases. Because assessments are completed in everyday environments and without a p...

mhealth.jmir.org

"Clocks" that relate amyloid and tau PET to time were used to examine the timing of biomarker changes (including plasma biomarkers) in Alzheimer disease. Plasma Aβ42/40 changes very early! onlinelibrary.wiley.com/doi/10.1002/... #ENDALZ

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Objective The objective of this study was to evaluate the timing of change of Alzheimer's disease (AD) plasma biomarkers (Aβ42/Aβ40, p-tau217, p-tau181, GFAP, and NfL) from six different assay platf.....

onlinelibrary.wiley.com

Practical information for clinicians on selection and interpretation of different biomarker tests for Alzheimer disease: practicalneurology.com/diseases-dia...

Selection and Interpretation of Biomarker Tests for Alzheimer Disease

Diagnostic tests for Alzheimer disease can help guide clinical management, but results must be interpreted carefully.

practicalneurology.com

Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Alzheimer's disease drug development pipeline: 2025

Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov. The registry presents a variety of types of information related to the planned clinical trial. We assess clinic...

alz-journals.onlinelibrary.wiley.com

From clinical trials to practice, WashU Medicine’s Memory Diagnostic Center offers top-tier, end-to-end Alzheimer's care. Now, a promising new study paves the way for clinics worldwide to adopt our elevated standard of outpatient care and infrastructure. 🔗 medicine.washu.edu/news/drug-to...

Development of Simple Risk Scores for Prediction of Brain β-Amyloid and Tau Status in Older Adults With Mild Cognitive Impairment: A Machine Learning Approach url:https://academic.oup.com/psychsocgerontology/article-abstract/doi/10.1093/geronb/gbaf085/8125623

Genetic studies reveal protective variants that delay Alzheimer's, offering insights into new therapies. Be sure to check out our new review on protective genetic variants in Lancet Neurology, along with the editorial that features this research! www.sciencedirect.com/science/arti...

Protective genetic variants against Alzheimer's disease

Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer's disease. Protective genetic variants th…

sciencedirect.com

UPDATE: More than 5,000 homes were impacted, and 38 people were injured after an EF3 tornado tore across St. Louis. via @stlpublicradio.bsky.social

‘I just fell to my knees and cried’: St. Louisans face devastating damage after tornado that killed 5

More than 5,000 homes were impacted, and 38 people were injured after an EF3 tornado tore across St. Louis.

stlpr.org