Svasti Haricharan

@svasti.bsky.social

Cancer biologist interested in host characteristics; advocate for equitable research environments; associate professor at SDSU; posts my own

The other alternatives to believing the score is biased is that to believe that: - that "exceptional" manuscripts are more likely to be by men or - the score does not really measure "exceptional" manuscripts Which is it?

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

    U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci 
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.

Shout out from @sdsuresearch.bsky.social on our recent paper looking at subcellular localization of proteins ss a sometimes overlooked high potential avenue for cancer biomarker discovery. Finding the right patient for the tx is a battle that continues to be fought www.sdsu.edu/news/2026/04... 🧬🧪

Study uncovers potential cancer treatment that is readily available | News | SDSU

SDSU researchers have identified a solution to reduce mortality in the deadliest type of breast cancer

sdsu.edu

Svasti Haricharan@svasti.bsky.social · 8mo ago

Good science news to greet the holidays. Our paper is now out @natcomms.nature.com: www.nature.com/articles/s41.... Outstanding work by two of my postdocs, Aloran and Tyler, and collabs with Nic Fusco, Carol Manhart @templechemistry.bsky.social & Matthew Bainbridge @radychildrensoc.bsky.social 🧵🧪/1

Every day I talk to other cancer researchers, committed to soldiering on as long as poss, but many of us see the writing on the wall & cannot help but be despondent. Pharma co.s otoh are happy to tell us that if we cannot make breakthroughs, they'll take ones from China. So there's that, I suppose.🧪

Colette Delawalla, PhD@cdelawalla.bsky.social · 5mo ago

The people developing the treatment for your cancer diagnosis in 25 years are not ok. American Science is not ok...and Republicans are letting it happen. www.statnews.com/2026/03/19/n...

Everything happened because of someone else (unconnected to POTUS), he is a disinterested scientist only motivated by a love of humanity, butter wouldn't melt in his mouth. The absence of any attempt at taking ownership of the debacle that is American research today was appalling to watch

Jenna Norton@jenna-m-norton.bsky.social · 5mo ago

In response to a question from Pocan about students choosing not to enter science careers given the instability during the House Appropriations Hearing, Bhattacharya insists the US is the best place for biomedical research. He ignores the very real disruption that occurred last year under his watch.

I read this piece, and I'm not going to lie, it is deeply shocking to think that we have gone so far off the rails that we can think and write and publish that the main purpose of a graduate student is to "be productive" on day 1.

Justin Kiggins@neuromusic.bsky.social · 5mo ago

Huh. It's almost like grad students are treated as cheap labor who have been undercut by a cheaper labor source 🤔 cc @drugmonkey.bsky.social www.science.org/content/arti...