www.biorxiv.org/content/10.1... New preprint from our lab: "Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging models" Performed by my talented graduate student @omercane.bsky.social

Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging models

Cellular reprogramming with transient OSKM expression can reverse aging phenotypes, but genetic factor delivery introduces heterogeneous expression, reprogramming-associated stress, and barriers for t...

biorxiv.org

Check our recent work on a CRISPR screen to identify regulators of human somatic cell reprogramming where we identify USP22 as an important factor. Now published @CommsBio. rdcu.be/ed1l6

A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming

Communications Biology - Ubiquitin-specific peptidase 22 (USP22) is identified as a key chromatin-based barrier to human iPSC derivation through a chromatin-focused CRISPR-Cas9 screen.

rdcu.be

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!