Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀 Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA) www.biorxiv.org/content/10.6...

Iterative engineering of a compact Cas9 ortholog for in vivo gene editing via single AAV delivery

The development of compact and efficient CRISPR-Cas systems is crucial for biomedical and therapeutic genome editing, particularly in vivo applications based on viral delivery. Here, we performed a co...

biorxiv.org

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers

The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

biorxiv.org

New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development. These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention. www.embl.org/news/science...

📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways www.biorxiv.org/content/10.1...

Endogenous variability in transcription factor concentrations shapes their genome-wide occupancy

The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...

biorxiv.org

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

embopress.org

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

biorxiv.org

🤩🤩 it’s been a while

Greg Jenner (Historian)@gregjenner.bsky.social · last yr.

I CANNOT STOP GIGGLING!!!! #COYS

Awhh, my lab are absolute legends!

We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training. The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social. #job #internship; see info below...

Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome? Funding call with deadline 15 June, decisions in July. www.embl.org/about/info/s...

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Group Leader - Molecular Mechanisms of Environmental Adaptation

We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

embl.wd103.myworkdayjobs.com

Last day to apply for a postdoc in systems epigenomics in sunny Rome! www.embl.org/jobs/positio...

EMBL Jobs

We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

embl.org

Jamie Hackett@jamiehackett.bsky.social · 2y ago

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring www.nature.com/artic...

Paternal microbiome perturbations impact offspring fitness

Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.

nature.com

Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins

James Lloyd 🧬@jamespblloyd.bsky.social · 2y ago

After a year of extra work and edits with @joncahn.bsky.social, I am overjoyed to share the final version of our work: Characterization of DNA methylation reader proteins of Arabidopsis thaliana Published in Genome Research @genomeresearch.bsky.social genome.cshlp.org/content/earl...

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now www.grc.org/histone-and-...

Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:

Open Targets@opentargets.org · 2y ago

NEW: Postdoctoral Fellow with @ewanbirney The project is based in the Birney Research group at @emblebi and working closely with Open Targets and @MoritzGerstung's group at DKFZ

One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥

Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city: institute-genetics-cancer.ed.ac.uk/igc-graduate... Please share 🙏 (1/2)

MRC four-year International PhD programme: Human Genetics, Genomics and Disease

Applications now open.

institute-genetics-cancer.ed.ac.uk

The good news: you only click on the "join" button once and then you following all the pack persists in the absence of the initiating stimulus. 😀 In all seriousness, a stellar group of folks to follow.

Duncan Sproul@sproullab.bsky.social · 2y ago

We've now filled one #Epigenetics, Chromatin and Gene regulation starter pack. Thanks for all the enthusiasm and support, if you'd like to be listed @raduzabet.bsky.social has been hard at work getting part II up and running: go.bsky.app/SqLa3aw

Protein-based inheritance could be the new frontier in understanding transgenerational epigenetic inheritance. Great preview from @odedrechavi.bsky.social and @ethanewe.bsky.social on a very interesting new paper from @wbderry.bsky.social lab.

Oded Rechavi@odedrechavi.bsky.social · 2y ago

"Leaving sticky notes for the children" - Here's a new "Dispatch" @ethanewe.bsky.social and I wrote in @currentbiology.bsky.social about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social) www.sciencedirect.com/science/arti...

We are beginning to understand how the full repertoire of inheritable units can affect phenotypic variability Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…

Oded Rechavi@odedrechavi.bsky.social · 2y ago

"Leaving sticky notes for the children" - Here's a new "Dispatch" @ethanewe.bsky.social and I wrote in @currentbiology.bsky.social about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social) www.sciencedirect.com/science/arti...

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025 Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts) www.grc.org/developmenta...

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

Many other super lab members not (yet) on Bluesky! So finally, two postdocs that just moved on... @denbobalab.bsky.social has established his group at MPI on #microbiome-germline axis. @mdura.bsky.social has just preprinted on #intergenerational-inheritance and is on the market! Check them out!

Jamie Hackett@jamiehackett.bsky.social · 2y ago

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇

Looks like a really interesting preprint from James Turner’s lab (who needs to migrate over here!) www.biorxiv.org/content/10.1...

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo

Sex chromosomes are emerging as key regulators of adult health and disease in males (XY) and females (XX), but their impact on embryo development is poorly understood. Using single-cell RNA sequencing...

biorxiv.org

Don’t miss @steliostsagkris.bsky.social for infinite technical knowledge of CRISPR perturbation screening! Stelios is also the lab gastruloid guru 🧫 Always has interesting and constructive takes on papers so keep an eye on this one!

Jamie Hackett@jamiehackett.bsky.social · 2y ago

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇

Fearless grad student @catrinteleri.bsky.social leads a major computational analysis project. Want to discuss polycomb function, ask Catrin! More of a silent scroller than prolific poster, if we all follow Catrin - apart from being quite funny - we’ll hear more of her insights!

Jamie Hackett@jamiehackett.bsky.social · 2y ago

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇

We are blessed to have @bbbranjan.bsky.social. Follow Bobby for hot takes on preprints, microbiome and ML. Original computational biologist now wetlab guru! He also just co-first published a cracking preprint Oh, and he’s looking for ML/AI positions later next year👌

Jamie Hackett@jamiehackett.bsky.social · 2y ago

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇