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Terkild Brink Buus

@terkild.bsky.social

Associate Professor intrigued by skin immunology, T cell lymphoma, S. aureus-T cell interactions and single-cell analyses at University of Copenhagen @ucph.bsky.social @sic-ucph.bsky.social

77 Posts2331 Follower289 Folgt
Terkild Brink Buus@terkild.bsky.social · 4mo ago

New from our group: in CTCL, S. aureus is not just a bystander. Staphylococcal enterotoxins activate malignant + non-malignant T cells, amplifying cytokines that damage the epidermal barrier. This links colonization directly to pathology. doi.org/10.1111/all.70292 @allergy-eaaci.bsky.social 1/8

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T-cell release of barrier-repressing cytokines (IL-4, IL-13, IL-22, OSM...

doi.org

Allergy EAACI@allergy-eaaci.bsky.social · 4mo ago

Open Access: Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma. First authors: Maria Gluud; corresponding authors: Terkild B. Buus, Niels Ødum 👉 doi.org/10.1111/all.70292 #Allergy_journal

Staphylococcus aureus, commonly colonising cutaneous T cell lymphoma (CTCL) patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T-cell release of barrier-repressing cytokines (IL-4, IL-13, IL-22, oncostatin M). Cytokine signalling drives JAK-dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic-mediated eradication of S. aureus induces skin barrier protein expression and inhibits the inflammatory cycle.
Terkild Brink Buus@terkild.bsky.social · 9mo ago

Glad to see our article on how cancer drugs and bacterial (S. aureus) infections can affect co-existing malignant subclones very differently in cutaneous T-cell lymphoma. Thank you Cancer Discovery (@aacrjournals.bsky.social) for the beautiful title-page graphics!

Front page of article Buus et al. 2025 Cancer Discovery, including graphics showing red and orange malignant T cell subclones in a blue skin environment.
Terkild Brink Buus@terkild.bsky.social · last yr.

❗How can a cancer exploit its environment and still resist treatment? ✅The answer: co-existing malignant subclones. Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵 doi.org/10.1158/2159...

Schematic figure showing divergent evolution of malignant subclones and how they migrate to different tissue compartments (blood vs skin), respond differently to extrinsic stimuli such as Staphylococcus aureus enterotoxins, and how subclones differ in their intrinsic resistance to anti-cancer drugs.
@niels-odum.bsky.social · last yr.

Congratulations Terkild and the team👏💪😊 very important new knowledge on the intricacies of this horrible cancer - this new understanding of coexisting yet specialized cancer subclones is a key discovery for a truly targeted treatment in the future !!!! Bravo 👏👏👏

Terkild Brink Buus@terkild.bsky.social · last yr.

❗How can a cancer exploit its environment and still resist treatment? ✅The answer: co-existing malignant subclones. Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵 doi.org/10.1158/2159...

Schematic figure showing divergent evolution of malignant subclones and how they migrate to different tissue compartments (blood vs skin), respond differently to extrinsic stimuli such as Staphylococcus aureus enterotoxins, and how subclones differ in their intrinsic resistance to anti-cancer drugs.
Terkild Brink Buus@terkild.bsky.social · 2y ago

Can bacterial infections make cancer cells resistant to treatment? In Sézary Syndrome (SS), it turns out they can! Want to know more? I will summarize some highlights from our study below. doi.org/10.1182/bloo...

Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

Enterotoxins from S aureus bacteria induce drug resistance in primary malignant T cells in SS.Targeting bacteria, their toxins, and downstream signaling pa

doi.org