It's Purple Day! Discussing ion channels, the menstrual cycle, sleep, and genetic epilepsies, Lucy, Daniel, Tina and Jessica give us a glimpse of the diversity and complexities of this wide-ranging, multi-faceted disorder as well as approaches to treatment. #epilepsy #purpleday edin.ac/4t1SMfU

Registration for the EMBO workshop «Organelle dynamics in health and disease» is open : meetings.embo.org/event/26-organelle-dynamics Happy to share this exciting programme with top-notch international speakers. @edinunineuro.bsky.social Sponsors: @embo.org @neurochemistry.org @ibroorg.bsky.social

Happy Purple Day from MMEC @edinunineuro.bsky.social @cmvm-edinburghuni.bsky.social @sidb-edinburgh.bsky.social

Happy Purple Day from the Cousin lab!!

• We are delighted to contribute to this work just out in @jneurochem.bsky.social, where we collaborate with the BlueSkyless Smillie lab to reveal that Huntington’s Disease model neurons display excess activity-dependent bulk endocytosis (ADBE).

ISN is seeking volunteers for its committees! This is a great opportunity to contribute, connect, and help lead our global community. 🗓️ Apply by June 29 📨 Email: secretariat@neurochemistry.org with a short bio and brief statement on why you’re applying. #WeAreNeurochemistry #neurosky

Fantastic effort from the Presynaptic Pacers, covering the slow leg from an old PI in their team at the Hairy Haggis relay!! All done to support @epilepsyinst.bsky.social!

Huge thanks to James, Jess, Zita and Angus for manning the @mmecepilepsy.bsky.social table today at the CDBS friends and family day! Great to spread the word about the amazing work the Centre is doing!

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications

GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...

nature.com

All funds raised go to @epilepsyinst.bsky.social !!

The Cousin Lab@thecousinlab.bsky.social · last yr.

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

2025 Hairy Haggis Marathon for Epilepsy Research Institute UK

Help Han Tan raise money to support Epilepsy Research Institute UK

shorturl.at

At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh

2025 Hairy Haggis Marathon for Epilepsy Research Institute UK

Help Han Tan raise money to support Epilepsy Research Institute UK

shorturl.at

Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...

Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models.

Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...

biorxiv.org

This would not have been possible without the heroic effort of Dr. Katherine Bonnycastle who invested years in this long-term project! Thanks also to Sarfaraz for the blots!

The Cousin Lab@thecousinlab.bsky.social · last yr.

These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.

These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.

The Cousin Lab@thecousinlab.bsky.social · last yr.

Our latest paper is out in Molecular Autism! We reveal that in neurons from five independent rat models of monogenic Autism Spectrum Disorder (ASD), activity-dependent endocytosis (ADBE) is selectively depressed, with no other synaptic vesicle recycling phenotype. Link to paper - rdcu.be/eh4Qa

Our latest paper is out in Molecular Autism! We reveal that in neurons from five independent rat models of monogenic Autism Spectrum Disorder (ASD), activity-dependent endocytosis (ADBE) is selectively depressed, with no other synaptic vesicle recycling phenotype. Link to paper - rdcu.be/eh4Qa

🎉 Congrats to Sabrin Haddad - winner of the 2024 JNC Young Scientist Paper of the Year Award (in honor of Mark A. Smith)! Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy. 🔗Read here: bit.ly/3EjpeXq #WeAreNeurochemistry #YoungScientistAward

No sign of the aurora but at least I got to see the castle lit in purple for #epilepsy #PurpleDay ❤️

It's #PurpleDay: a day to increase awareness of #epilepsy. Hannah, a 1st year PhD @edinuni-irr.bsky.social, has written about the need to investigate the neurodevelopmental consequences of early-onset epilepsy and risk factors contributing to them: edin.ac/4j6PMKh

Happy Purple Day from us to the whole epilepsy community 💜! #PurpleDay2025

Job Opportunity at JNC!✍️ The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community. ✅ Remote & flexible ✅ Support publishing ✅ Global network 🔗Apply here: bit.ly/3FAs1M6

We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.

Come and join our @epilepsyinst.bsky.social Doctoral Training Centre. Are you bright and passionate about epilepsy research? Want to join a nurturing and exciting programme? We have space for one more exceptional student. For details see www.muirmaxwellcentre.com/doctoral-tra...

We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !

The Donlin-Asp Lab ( @pdaphd.bsky.social ) is hiring a postdoc to conduct primary research into how neurons transport mRNA to distal sites and use these mRNAs as substrates for local protein synthesis during synaptic plasticity. elxw.fa.em3.oraclecloud.com/hcmUI/Candid... @edinunineuro.bsky.social

New review out from our lab on SV2A! Thanks to James for all his hard work on this!

Journal of Neurochemistry@jneurochem.bsky.social · 2y ago

New in #JNC: A review article from @thecousinlab.bsky.social 📄 "SV2A is an enigmatic presynaptic protein. We discuss its key role in trafficking Synaptotagmin-1, how this controls neurotransmitter release, and how its dysfunction may result in epilepsy." 👉 bit.ly/3PUKcOE

🌟 ISN Membership 2025 is Open! Join or renew today to unlock: ✅ Discounted ISN meeting registration fees ✅ Access to grants & awards ✅ Free online access to JNC ✅ Discounted JNC open access fees Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA #WeAreNeurochemistry #neuroskyence

@thecousinlab.bsky.social have just joined BlueSky, please feel free to follow to keep up with all things presynaptic!