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The Gu Lab

@thegulab.bsky.social

Lab of Chenghua Gu - Neurobiology Department @HarvardMed Focused on neuro-vascular interactions 🧠

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The Gu Lab@thegulab.bsky.social · last wk.

Happy to share our Review, "Cellular and signalling mechanisms that regulate the blood-brain barrier" in @natrevmcb.nature.com www.nature.com/articles/s41... If you don't have subscription access, you can read it through this link: rdcu.be/fuyrO

Cellular and signalling mechanisms that regulate the blood–brain barrier - Nature Reviews Molecular Cell Biology

This Review summarizes the latest advances in blood–brain barrier (BBB) research, highlighting how emerging findings on the modulation of BBB function and heterogeneity by cellular interactions and si...

nature.com

The Gu Lab@thegulab.bsky.social · last yr.

We’re excited to share our recent study published in @cellpress.bsky.social! In this work, we show that brain endothelial cells, connected by gap junctions, form a signaling highway to enable fast, long-range arterial vasodilation in neurovascular coupling. You can find it below:

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling

Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.

cell.com